公开(公告)号：US20130324992A1

公开(公告)日：2013-12-05

申请号：US13484586

申请日：2012-05-31

Applicant: Ronald Bush ,  Brian J. Smith ,  Anthony Johnson

Inventor： Ronald Bush ,  Brian J. Smith ,  Anthony Johnson

IPC: A61B18/18

CPC classification number: A61B18/1477 ,  A61B2017/00526 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00404

Abstract: A radio frequency sclerotherapy system includes a needle assembly with a thin (26 to 32 gauge) solid conductive needle, about 1.25 inches long. A multilayer coating is applied over a proximal portion of the needle leaving an uncoated distal tip, about 0.10 inches long, exposed. The multilayer coating is an electric and thermal insulator. An electrical plug electrically coupled to the proximal end of the wire. The multilayer coating provides a palpable transition. A generator supplies voltages in the range of 300V to −100V, at frequencies of 1 MHz to 50 MHz, with voltage spikes having a time from rise to fall of up to 100 nS and a low voltage between voltage spikes for about twice the duration of the time from rise to fall of the voltage spikes.

Abstract translation: 射频硬化治疗系统包括具有约1.25英寸长的薄（26至32号）固体导电针的针组件。 将多层涂层施加在针的近端部分上，留下约0.10英寸长的未涂覆的远端，露出。 多层涂层是电绝缘体和热绝缘体。 电连接到电线的近端的电插头。 多层涂层提供了明显的转变。 发电机以1MHz至50MHz的频率提供300V至-100V范围内的电压，电压尖峰时间从上升到下降至100nS，电压尖峰之间的低电压约为持续时间的两倍 时间从上升到下降的电压尖峰。

公开(公告)号：US20130286945A1

公开(公告)日：2013-10-31

申请号：US13927033

申请日：2013-06-25

Applicant: John Fulknier ,  Brian J. Smith

Inventor： John Fulknier ,  Brian J. Smith

IPC: H04W40/00

CPC classification number: H04W40/00 ,  H04L45/00 ,  H04L45/60 ,  H04W4/80 ,  H04W24/08 ,  H04W28/08 ,  H04W48/18 ,  H04W76/15 ,  H04W84/12 ,  H04W84/18 ,  H04W88/10 ,  H04W88/16

Abstract: A wireless mobile router (140) includes wireless network interfaces (202) and (218) attached to a network controller (142). The wireless network interface (202) communicates with a cellular network (110) to access cellular network services. The wireless network interface (218) and the network controller (142) comprise a WLAN (170) or PAN (180) and a network router hosting a plurality of client devices. Each client device may access a wide area network, WAN over the cellular network. The wireless mobile router (140) is configured to exchange various cellular network signals with various WLAN and PAN networks. The wireless mobile router (140) is particularly suitable for use in a vehicle or at locations where WAN access is not readily available.

Abstract translation: 无线移动路由器（140）包括附接到网络控制器（142）的无线网络接口（202）和（218）。 无线网络接口（202）与蜂窝网络（110）通信以接入蜂窝网络服务。 无线网络接口（218）和网络控制器（142）包括WLAN（170）或PAN（180）和托管多个客户端设备的网络路由器。 每个客户端设备可以通过蜂窝网络访问广域网WAN。 无线移动路由器（140）被配置为与各种WLAN和PAN网络交换各种蜂窝网络信号。 无线移动路由器（140）特别适用于车辆或WAN接入不容易获得的位置。

公开(公告)号：US20080027145A1

公开(公告)日：2008-01-31

申请号：US10588687

申请日：2005-02-03

Applicant: David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

Inventor： David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

IPC: A61K35/00 ,  A61P35/00 ,  G01N33/48 ,  G01N33/53

CPC classification number: C07K14/4747

Abstract: The present invention relates generally to therapeutic molecules useful for inducing apoptosis of particular cells such as, but not limited to, cancer cells and methods for generating and/or selecting same. The present invention further provides methods for inducing apoptosis of cells such as cancer cells and pharmaceutical compositions useful for same. The present invention further provides methods for generating or selecting therapeutic agents capable of inducing apoptosis of particular cells by the selective inhibition of pro-survival proteins. The present invention further provides a computational approach to therapeutic molecule design based on structure-binding characteristics.

Abstract translation: 本发明一般涉及用于诱导特定细胞凋亡的治疗分子，所述特定细胞例如但不限于癌细胞，以及用于产生和/或选择癌细胞的方法。 本发明还提供诱导细胞凋亡的方法，例如癌细胞和对其有用的药物组合物。 本发明还提供了通过选择性抑制前体存活蛋白来产生或选择能够诱导特定细胞凋亡的治疗剂的方法。 本发明还提供了基于结构结合特征的治疗分子设计的计算方法。

公开(公告)号：US07269829B2

公开(公告)日：2007-09-11

申请号：US10902034

申请日：2004-07-30

Applicant: Brian J. Smith ,  Eric Schafer

Inventor： Brian J. Smith ,  Eric Schafer

IPC: G05D11/00 ,  G05D7/00 ,  G06F9/44 ,  G06F3/00 ,  G06F15/167

CPC classification number: G05B19/0426 ,  G05B2219/23304 ,  G05B2219/2625

Abstract: A remote download of microprocessor code for an irrigation controller is provided. A microprocessor, on an irrigation controller, is executing program code (in volatile memory) and receives a remote download of updated program code, which it stores into non-volatile random access memory, e.g., flash memory. The microprocessor is configured to receive the updated program code, via a communication port, and to store the updated program code into the non-volatile flash memory. Optionally, the updated program code is received at multiple controllers via a global transmission on a communication bus. The microprocessor receives a communication causing it to re-start. In response to the re-start communication, the microprocessor fetches the updated program code stored in the non-volatile flash memory into the program memory RAM to replace the original program code, and begins execution of the updated program code in the program memory RAM. A device is also provided for directing the download of program code to irrigation controllers. Options provide for global download of entirely new program code, global and/or individual download of particular pages of updated program code, and global downloads to controllers grouped by communication speed.

Abstract translation: 提供远程下载用于灌溉控制器的微处理器代码。 灌溉控制器上的微处理器正在执行程序代码（在易失性存储器中）并且接收更新的程序代码的远程下载，其被存储到非易失性随机存取存储器，例如闪速存储器中。 微处理器被配置为经由通信端口接收更新的程序代码，并将更新的程序代码存储到非易失性闪存中。 可选地，更新的程序代码经由通信总线上的全局传输在多个控制器处被接收。 微处理器接收到使其重新启动的通信。 响应于重新启动通信，微处理器将存储在非易失性闪速存储器中的更新的程序代码取回到程序存储器RAM中以替换原始程序代码，并开始执行程序存储器RAM中更新的程序代码。 还提供了用于将程序代码下载到灌溉控制器的装置。 选项提供全球下载全新程序代码，全球和/或个别下载更新程序代码的特定页面，以及通过通信速度分组的控制器的全局下载。

公开(公告)号：US07250860B2

公开(公告)日：2007-07-31

申请号：US10952821

申请日：2004-09-30

Applicant: Brian J. Smith ,  Eric Schafer

Inventor： Brian J. Smith ,  Eric Schafer

IPC: G08B1/08

CPC classification number: H04M3/42144 ,  H04M3/42348 ,  H04M2201/14 ,  H04M2201/30

Abstract: A controller (301), for example on a field interface of a resource management system (300), determines a location of a mobile object (303a, 303b, 303c) and controls an environment thereof. The controller (301) receives, via a first transceiver (307), a communication including information representative of the mobile object; receives a command via a second transceiver (317) and controls the environment outside of the mobile object responsive to the command and/or the communication. A controller, for example on the mobile object (303a, 303b, 303c), detects a location of the mobile object (303a, 303b, 303c) via device (305a, 305b, 305c). The controller collects information about the mobile object including location; transmits, to a controller via its transceiver, a communication including the information; receives a command via its transceiver; and controls operation of the mobile object responsive to the command.

Abstract translation: 控制器（301）例如在资源管理系统（300）的现场接口上确定移动对象（303a，303b，303c）的位置并控制其环境。 控制器（301）经由第一收发器（307）接收包括表示移动对象的信息的通信; 经由第二收发器（317）接收命令，并响应于该命令和/或通信来控制移动对象外的环境。 例如在移动物体（303a，303b，303c）上的控制器经由设备（305a，305b，305c）检测移动物体（303a，303b，303c）的位置。 控制器收集有关移动对象的信息，包括位置; 通过其收发器向控制器发送包括该信息的通信; 通过收发器接收命令; 并响应于该命令来控制移动对象的操作。

公开(公告)号：US06898467B1

公开(公告)日：2005-05-24

申请号：US10627877

申请日：2003-07-28

Applicant: Brian J. Smith ,  Eric Schafer

Inventor： Brian J. Smith ,  Eric Schafer

IPC: G05B15/02 ,  G05B19/042 ,  G06N5/00

CPC classification number: G05B15/02 ,  G05B19/0421 ,  G05B2219/2229 ,  G05B2219/23043 ,  G05B2219/25187 ,  G05B2219/25192 ,  G05B2219/25232 ,  G05B2219/25428 ,  G05B2219/2625

Abstract: A system and method for operating a distributed control network for irrigation management. The system incorporates several irrigation controllers wherein each of the controllers can transmit, receive and respond to commands initiated by any device or satellite controller on the network, a communication bus that is connected to the controllers, a central computer that is connected to the bus, several sensing devices that are connected to each controller, and several sprinkler valves that are connected to each controller. The controllers can be operated in local mode via a user interface and in a remote mode via a wireless connection. The controllers are capable of monitoring and acknowledging the commands that are transmitted on the bus.

Abstract translation: 一种运行灌溉管理分布式控制网络的系统和方法。 该系统包括几个灌溉控制器，其中每个控制器可以发送，接收和响应由网络上的任何设备或卫星控制器发起的命令，连接到控制器的通信总线，连接到总线的中央计算机， 连接到每个控制器的几个感测装置和连接到每个控制器的几个喷洒阀。 控制器可以通过用户界面以远程模式通过无线连接在本地模式下运行。 控制器能够监视和确认在总线上传输的命令。

公开(公告)号：US06311216B1

公开(公告)日：2001-10-30

申请号：US09086843

申请日：1998-05-29

Applicant: Brian J. Smith ,  Hans Hurvig

Inventor： Brian J. Smith ,  Hans Hurvig

IPC: G06F15173

CPC classification number: H04L67/2814 ,  G06F17/30902 ,  H04L69/329

Abstract: A method, computer program product, and system for directly accessing URL data object requests in a proxy server array. A URL data object request is generated by an enabled client to request a URL data object that resides in the local cache of proxy server in an array of proxy servers configured as a distributed cache. The enabled client will deterministically identify the residing proxy server based on information residing thereon without resorting to expensive query-response transactions, such as those that occur in proxy server arrays using ICP, or routing the URL data object request through different proxy servers of the array. An array membership list containing array membership information is available at each and every proxy server as well as all enabled clients. This list is used in conjunction with the URL as the information for identifying the correct proxy server where the URL data object resides. First, a deterministic hash value is computed for each proxy server name and the URL. Next, a combined hash value is computed that combines the URL hash value with each proxy server hash value. Finally, the proxy server with the highest “score” or combined hash value is identified as the proxy server where the desired URL data object should reside in local cache storage. Since the array membership list, the URL, and the hashing algorithm are the same at all enabled clients, the same proxy server will be identified as having the URL data object regardless of which enabled client generated the URL data object request.

Abstract translation: 一种用于直接访问代理服务器阵列中的URL数据对象请求的方法，计算机程序产品和系统。 URL数据对象请求由启用的客户端生成，以请求驻留在配置为分布式缓存的代理服务器阵列中的代理服务器的本地缓存中的URL数据对象。 启用的客户端将基于驻留在其上的信息来确定性地识别驻留的代理服务器，而不需要使用诸如使用ICP的代理服务器阵列中出现的昂贵的查询 - 响应事务，或者通过阵列的不同代理服务器路由URL数据对象请求 。 包含数组成员身份信息的数组成员列表可在每个代理服务器以及所有已启用的客户端上使用。 该列表与URL一起用作用于标识URL数据对象所在的正确代理服务器的信息。 首先，为每个代理服务器名称和URL计算确定性哈希值。 接下来，计算将URL哈希值与每个代理服务器哈希值组合的组合哈希值。 最后，具有最高“分数”或组合哈希值的代理服务器被识别为代理服务器，其中期望的URL数据对象应驻留在本地高速缓存存储器中。 由于阵列成员资格列表，URL和散列算法在所有已启用的客户端都相同，所以相同的代理服务器将被标识为具有URL数据对象，而不管哪个启用的客户端生成了URL数据对象请求。

公开(公告)号：USD445653S1

公开(公告)日：2001-07-31

申请号：US29127406

申请日：2000-08-04

Applicant: Brian J. Smith

Designer： Brian J. Smith

公开(公告)号：US5860715A

公开(公告)日：1999-01-19

申请号：US818740

申请日：1997-03-14

Applicant: Dan Lohde ,  Noorlah N. Beidokhti ,  Brian J. Smith ,  Jeff L. Tipton

Inventor： Dan Lohde ,  Noorlah N. Beidokhti ,  Brian J. Smith ,  Jeff L. Tipton

IPC: A47B45/00 ,  H02B1/50 ,  A47B81/00

CPC classification number: A47B45/00 ,  H02B1/50

Abstract: An enclosure for housing electronic controls and devices that provides exceptional access to all sides of the enclosure and is both secure and aesthetically pleasing. The enclosure has a frame, semi-cylindrical doors, a top assembly, and a mounting base. Each of the doors has a door retaining member on its inner lower surfaces which engages and is supported by a receiving member mounted to a lower portion of the frame. The doors may be pivoted open and closed about the retaining and receiving members or may be completely removed from the base by simply lifting the doors off of the frame. Removal of the doors allows unobstructed access to the interior of the enclosure. The top assembly mounts on top of the frame and moves between a closed position and an open position. The top assembly includes a rim which overlaps and engages the top surfaces of the doors to securely retain the doors in the closed position. An opening and closing system mounted on the frame supports the top assembly in the open position. The enclosure is further provided with a lock to secure the top and doors in the closed position and prevent tampering by unauthorized persons.

Abstract translation: 用于容纳电子控制和设备的外壳，可以非常方便地进入外壳的各个环节，既安全又美观。 外壳具有框架，半圆柱形门，顶部组件和安装基座。 每个门在其内下表面上具有门保持构件，其接合并由安装到框架的下部的接收构件支撑。 门可以围绕保持和接收构件枢转打开和关闭，或者可以通过简单地将门从框架提起而从基座完全移除。 门的拆卸允许不受阻碍地进入外壳的内部。 顶部组件安装在框架的顶部，并在关闭位置和打开位置之间移动。 顶部组件包括与门的顶表面重叠并接合的边缘，以将门牢固地保持在关闭位置。 安装在框架上的打开和关闭系统将顶部组件支撑在打开位置。 外壳还设有锁，以将顶部和门固定在关闭位置，并防止未经授权的人员的篡改。

公开(公告)号：US20100235377A1

公开(公告)日：2010-09-16

申请号：US12401522

申请日：2009-03-10

Applicant: Sergly V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

Inventor： Sergly V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

IPC: G06F17/30 ,  G06F15/16 ,  G06F9/45

CPC classification number: G06F9/45516 ,  G06F12/0253

Abstract: Just in time compiled code and other data within a runtime environment may be shared between multiple applications by identifying common data objects and allowing two or more applications to access the data objects. While at least one application is accessing the objects, the objects may remain in memory. When all applications have stopped accessing an object, the object may be removed from memory. One embodiment may use a server process to manage various operations to facilitate sharing between various applications, such as identifying objects that may be removed from memory and adding newly created data to a database of sharable data.

Abstract translation: 通过识别公共数据对象并允许两个或更多个应用程序访问数据对象，可以在运行时环境中编译代码和其他数据可以在多个应用程序之间共享。 当至少一个应用程序正在访问对象时，对象可能会保留在内存中。 当所有应用程序都停止访问对象时，对象可能会从内存中删除。 一个实施例可以使用服务器进程来管理各种操作以促进各种应用之间的共享，诸如识别可以从存储器移除的对象并将新创建的数据添加到可共享数据的数据库。