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公开(公告)号:US20130023534A1
公开(公告)日:2013-01-24
申请号:US13637430
申请日:2011-03-26
申请人: Linda N. Casillas , Subhas J. Chakravorty , Patrick Eidam , Pamela A. Haile , Terry Vincent Hughes , Ami Lakdawala Shah , Lara Kathryn Leister , Nathan Andrew Miller , Attiq Rahman , Clark A. Sehon , Gren Z. Wang , Daohua Zhang
发明人: Linda N. Casillas , Subhas J. Chakravorty , Patrick Eidam , Pamela A. Haile , Terry Vincent Hughes , Ami Lakdawala Shah , Lara Kathryn Leister , Nathan Andrew Miller , Attiq Rahman , Clark A. Sehon , Gren Z. Wang , Daohua Zhang
IPC分类号: A61K31/5377 , C07D413/14 , C07D401/14 , C07D409/14 , C07D417/14 , C07D401/12 , C07D413/12 , A61K31/506 , C07D405/14
CPC分类号: C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.
摘要翻译: 公开了具有式(I)的化合物:其中Z,n,R 1,R 1A,R 3,R 4和R 5如本文所定义,及其制备和使用方法。
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公开(公告)号:US20130345258A1
公开(公告)日:2013-12-26
申请号:US14002147
申请日:2012-03-02
申请人: Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, JR. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, JR. , Gren Z. Wang
发明人: Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, JR. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, JR. , Gren Z. Wang
IPC分类号: C07D401/12 , C07D417/12 , C07D405/14
CPC分类号: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
摘要翻译: 公开了具有下式的化合物:其中R1,R2,R3和Z如本文所定义,以及制备和使用它们的方法。
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公开(公告)号:US09604963B2
公开(公告)日:2017-03-28
申请号:US14002147
申请日:2012-03-02
申请人: Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, Jr. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, Jr. , Gren Z. Wang
发明人: Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, Jr. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, Jr. , Gren Z. Wang
IPC分类号: C07D405/12 , C07D401/12 , A61K31/4709 , C07D405/14 , C07D417/12 , C07D215/44 , C07D417/14 , C07D471/04
CPC分类号: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号:US20130018039A1
公开(公告)日:2013-01-17
申请号:US13637443
申请日:2011-03-31
申请人: Vera Q. Bodmer , Linda N. Casillas , Michael P. DeMartino , Philip A. Harris , Bryan W. King , Ami Lakdawala Shah , Lara Kathryn Leister , Joshi M. Ramanjulu , Joseph J. Romano , Gren Z. Wang , Matthew A. Wilson , David Duff Wisnoski
发明人: Vera Q. Bodmer , Linda N. Casillas , Michael P. DeMartino , Philip A. Harris , Bryan W. King , Ami Lakdawala Shah , Lara Kathryn Leister , Joshi M. Ramanjulu , Joseph J. Romano , Gren Z. Wang , Matthew A. Wilson , David Duff Wisnoski
IPC分类号: A61K31/4184 , C07D401/14 , C07D405/14 , C07D235/14 , C07D417/14 , C07D403/14 , C07D471/04 , A61K31/5377 , A61K31/4439 , A61K31/428 , A61K31/4245 , A61K31/437 , A61K31/496 , A61P17/00 , A61P3/10 , A61P19/02 , A61P1/04 , A61P1/16 , A61P11/06 , A61P37/06 , C07D413/14
CPC分类号: C07D417/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds having the formula: wherein R1A, R1B, R2 and R3 are defined herein, and methods of making and using the same.
摘要翻译: 公开了具有下式的化合物:其中R1A,R1B,R2和R3如本文所定义,以及制备和使用该化合物的方法。
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15.Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors 有权
标题翻译: 含内含物的环状二胺及其衍生物作为Xa因子抑制剂公开(公告)号:US07205318B2
公开(公告)日:2007-04-17
申请号:US10801469
申请日:2004-03-16
申请人: Jennifer X. Qiao , Tammy C. Wang , Gren Z. Wang , Timur Gungor
发明人: Jennifer X. Qiao , Tammy C. Wang , Gren Z. Wang , Timur Gungor
IPC分类号: A61K31/445 , C07D453/02
CPC分类号: C07D213/64 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P4-M-M4I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译: 本申请描述了含有内酰胺的环状二胺及其衍生物
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