公开(公告)号：US11234913B2

公开(公告)日：2022-02-01

申请号：US15521058

申请日：2014-10-24

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz

IPC: A61K8/27 ,  A61Q11/00 ,  A61K8/365

Abstract: A method of preparing a zinc citrate-containing oral care composition, the method comprising: (a) adding zinc oxide to a solution of citric acid in a solvent to form a suspension; (b) agitating the suspension until a clear solution is obtained; and (c) adding an additional oral care ingredient to the solution obtained in (b). Also, a method of preparing a zinc citrate-containing oral care composition, the method comprising: (a) adding citric acid to a suspension of zinc oxide in a solvent; (b) agitating the suspension until a clear solution is obtained; and (c) adding an additional oral care ingredient to the solution obtained in (b). In both methods, steps (a) and (b) are carried out at a temperature of from 10° C. to 50° C. and the molar ratio of zinc oxide to citric acid in step (a) is about 3:2.

公开(公告)号：US11229591B2

公开(公告)日：2022-01-25

申请号：US16714871

申请日：2019-12-16

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Long Pan

IPC: A61K8/44 ,  A61K8/27 ,  A61K8/20 ,  A61Q11/00

Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.

公开(公告)号：US20160178617A1

公开(公告)日：2016-06-23

申请号：US14580485

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Harsh M. Trivedi ,  Lyndsay Schaeffer-Korbylo ,  Lynette Zaidel

IPC: G01N33/50 ,  G01N21/78

CPC classification number: G01N33/5082 ,  G01N21/78 ,  G01N33/84

Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample., contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.

Abstract translation: 用于测定来自口腔护理组合物的锌（II）离子的生物利用度的体外方法包括：提供包含口腔护理组合物的样品; 将样品与生物相关底物接触，将生物相关底物与样品分离;在选择的条件下使生物相关底物与指示剂接触，使得指示剂能够与锌（II）离子反应，并确定指示剂的吸光度 。 指示剂是钦康或其盐。 该方法可用于估计口腔护理组合物将治疗活性的锌（II）离子递送至口腔的能力。 还提供了在体外使用锌康和生物相关底物来确定来自包含锌源的口腔护理组合物的锌（II）离子的生物利用度。

公开(公告)号：US20160178527A1

公开(公告)日：2016-06-23

申请号：US14580510

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Ravi Subramanyam ,  Michael Prencipe

IPC: G01N21/78

CPC classification number: G01N21/78 ,  A61K8/466 ,  A61K2800/45 ,  A61Q11/00 ,  G01N21/77 ,  G01N21/79 ,  G01N33/20

Abstract: A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a colour; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the colour of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample comprises at least one source of the target metal ion. The indicator comprises zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).

Abstract translation: 测量来自两个或更多个样品的靶金属离子的相对释放速率的方法包括：（i）提供包含指示剂的溶液的至少两个等分试样，所述指示剂具有颜色; （ii）将样品分散到每个等分试样中; 和（iii）在步骤（ii）期间，在现场监测指示剂的颜色以确定目标金属离子从样品相对于彼此的释放速率。 每个样品包含至少一种目标金属离子源。 指标包括zincon。 样品是选自牙膏，牙胶和牙粉的口腔护理组合物。 目标金属离子选自亚锡和锌（II）。

公开(公告)号：US10773105B2

公开(公告)日：2020-09-15

申请号：US16425312

申请日：2019-05-29

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  Dandan Chen ,  Robert D'Ambrogio ,  Paul Thomson ,  Harsh Mahendra Trivedi ,  Michael Prencipe ,  James Masters ,  Stanislav Jaracz

IPC: A61Q11/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61Q17/00 ,  A61K8/21 ,  A61K8/22 ,  A61K8/27 ,  A61K8/97 ,  A61K36/9068 ,  A61K45/06

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US20170354578A1

公开(公告)日：2017-12-14

申请号：US15521058

申请日：2014-10-24

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz

IPC: A61K8/365 ,  A61K8/27 ,  A61Q11/00

CPC classification number: A61K8/365 ,  A61K8/27 ,  A61K2800/80 ,  A61K2800/805 ,  A61Q11/00

Abstract: A method of preparing a zinc citrate-containing oral care composition, the method comprising: (a) adding zinc oxide to a solution of citric acid in a solvent to form a suspension; (b) agitating the suspension until a clear solution is obtained; and (c) adding an additional oral care ingredient to the solution obtained in (b). Also, a method of preparing a zinc citrate-containing oral care composition, the method comprising: (a) adding citric acid to a suspension of zinc oxide in a solvent; (b) agitating the suspension until a clear solution is obtained; and (c) adding an additional oral care ingredient to the solution obtained in (b). In both methods, steps (a) and (b) are carried out at a temperature of from 10° C. to 50° C. and the molar ratio of zinc oxide to citric acid in step (a) is about 3:2.

公开(公告)号：US09354219B1

公开(公告)日：2016-05-31

申请号：US14580497

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Michael Prencipe

IPC: G01N33/20 ,  G01N21/78 ,  G01N21/77 ,  G01N21/79 ,  A61Q11/00

CPC classification number: G01N33/20 ,  A61Q11/00 ,  G01N21/77 ,  G01N21/78 ,  G01N21/79

Abstract: A method of detecting stannous ions that includes providing a zincon-containing indicator having a color, contacting the indicator with a sample, and detecting any resulting change in the color of the indicator, wherein a change in the color of the indicator from the color to colorless indicates that stannous ions are present in the sample. The method is useful for the analysis of oral care compositions. Also provided is the use of zinc on as an indicator for detecting stannous ions.

Abstract translation: 一种检测亚锡离子的方法，其包括提供具有颜色的含有蕴含锌的指示剂，使所述指示剂与样品接触，并检测所述指示剂的颜色的任何变化，其中所述指示剂的颜色从所述颜色变为 无色表示样品中存在亚锡离子。 该方法对口腔护理组合物的分析是有用的。 还提供了使用锌作为检测亚锡离子的指示剂。