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公开(公告)号：US20210275416A1
公开(公告)日：2021-09-09
申请号：US17249523
申请日：2021-03-04
发明人： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
摘要： The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
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公开(公告)号：US09435745B2
公开(公告)日：2016-09-06
申请号：US14580510
申请日：2014-12-23
摘要： A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a color; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the color of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample includes at least one source of the target metal ion. The indicator contains zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).
摘要翻译： 测量来自两个或更多个样品的靶金属离子的相对释放速率的方法包括：（i）提供包含指示剂的溶液的至少两个等分试样，所述指示剂具有颜色; （ii）将样品分散到每个等分试样中; 和（iii）在步骤（ii）期间，在现场监测指示剂的颜色，以确定目标金属离子从样品相对于彼此的释放速率。 每个样品包括至少一种目标金属离子源。 指标包含zincon。 样品是选自牙膏，牙胶和牙粉的口腔护理组合物。 目标金属离子选自亚锡和锌（II）。
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公开(公告)号：US20160240105A1
公开(公告)日：2016-08-18
申请号：US15028063
申请日：2014-10-09
CPC分类号： G09B23/283 , G09B5/02
摘要： The present application provides a tooth anatomy model comprising: a first layer representing tooth dentin, said first layer being made of a first material; and a sensor system associated with a surface of the first layer, which system is adapted to sense at least one of temperature and air pressure. The present application also provides a method of demonstrating tooth hypersensitivity using a tooth anatomy model.
摘要翻译： 本申请提供了一种牙齿解剖模型，包括：表示牙齿牙本质的第一层，所述第一层由第一材料制成; 以及与第一层的表面相关联的传感器系统，该系统适于感测温度和空气压力中的至少一个。 本申请还提供了使用牙齿解剖模型来证明牙齿超敏反应的方法。
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公开(公告)号：US12109285B2
公开(公告)日：2024-10-08
申请号：US15539748
申请日：2014-12-26
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam
摘要： An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including an inorganic zinc salt, and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.
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公开(公告)号：US11690791B2
公开(公告)日：2023-07-04
申请号：US15539725
申请日：2014-12-26
发明人： Shiri Nawrocki , Viktor Dubovoy , Long Pan , Baohua Qiao , Gregory Szewczyk , Ravi Subramanyam
摘要： An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including a zinc salt, a plurality of long chain polyphosphates having 6 or more phosphate polymer units, and a solvent, the relative amount of organic zinc salt and long chain polyphosphates provides a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.
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公开(公告)号：US11278481B2
公开(公告)日：2022-03-22
申请号：US16955308
申请日：2017-12-19
发明人： Zhigang Hao , Chi-Yuan Cheng , Long Pan , Ravi Subramanyam
摘要： The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
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公开(公告)号：US11186489B2
公开(公告)日：2021-11-30
申请号：US16206671
申请日：2018-11-30
摘要： Disclosed herein is zinc/amino acid functionalized silica, compositions comprising the same, and oral care methods and uses for such compositions.
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公开(公告)号：US09463159B2
公开(公告)日：2016-10-11
申请号：US14648868
申请日：2013-03-07
发明人： Shashank Potnis , Ravi Subramanyam , Rajitha Nair
IPC分类号： A61K36/00 , A61K9/00 , A61Q11/00 , A61K47/34 , A61K31/125 , A61K36/61 , A61K31/085 , A61K8/34 , A61K8/35 , A61K8/92 , A61K8/04
CPC分类号： A61K9/0053 , A61K8/042 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/922 , A61K31/085 , A61K31/125 , A61K36/61 , A61K47/34 , A61Q11/00 , A61K2300/00
摘要： Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.
摘要翻译： 本文公开了口服可接受的局部止痛凝胶，其包含镇痛油的混合物，其包含（a）丁香油和/或丁子香油，（b）冷却剂和（c）樟脑; 在口服可接受的凝胶基质中，凝胶基质在施用于牙齿后提供镇痛油混合物的控制释放; 以及制作和使用方法。
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公开(公告)号：US20160000667A1
公开(公告)日：2016-01-07
申请号：US14770901
申请日：2013-03-19
发明人： Shashank Potnis , Ravi Subramanyam , Navin Lewis
CPC分类号： A61K8/27 , A61K8/0237 , A61K8/042 , A61K8/19 , A61K8/25 , A61K8/365 , A61K8/73 , A61K2800/26 , A61K2800/262 , A61K2800/28 , A61K2800/48 , A61K2800/5922 , A61K2800/70 , A61K2800/882 , A61Q11/00
摘要： Described herein are toothpastes comprising a first dentifrice comprising a calcium carbonate abrasive and a second dentifrice comprising a zinc ion source in a gel base, wherein the second dentifrice is entrained as a stripe in the first dentifrice, as well as products comprising the toothpaste and methods of making and using the same.
摘要翻译： 本文描述的牙膏包括含有碳酸钙研磨剂的第一洁齿剂和在凝胶基质中包含锌离子源的第二洁齿剂，其中第二洁齿剂在第一洁牙剂中作为条带夹带，以及包含牙膏和方法的产品 制作和使用相同。
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公开(公告)号：US20240325440A1
公开(公告)日：2024-10-03
申请号：US18738288
申请日：2024-06-10
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam
IPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/00 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37
CPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/0063 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37 , A61K2800/262 , A61K2800/58
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
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