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公开(公告)号：US20170056388A1
公开(公告)日：2017-03-02
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US09522920B2
公开(公告)日：2016-12-20
申请号：US14313148
申请日：2014-06-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/47 , A61K31/424
CPC classification number: C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160333016A1
公开(公告)日：2016-11-17
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US09371331B2
公开(公告)日：2016-06-21
申请号：US14661797
申请日：2015-03-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/535 , C07D401/00 , C07D487/04 , C07D401/14 , C07D401/12 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US09206128B2
公开(公告)日：2015-12-08
申请号：US14358558
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/61 , C07D213/64 , C07D221/18 , C07D401/12 , C07D405/12 , C07D413/12
CPC classification number: C07D213/64 , C07D221/18 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
公开(公告)号：US09051269B2
公开(公告)日：2015-06-09
申请号：US14358455
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/62 , C07D213/64 , C07D405/12 , C07D401/12
CPC classification number: C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US10316023B2
公开(公告)日：2019-06-11
申请号：US15449706
申请日：2017-03-03
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven Magnuson , Christopher G. Nasveschuk , Richard Pastor , F. Anthony Romero , Alexander M. Taylor
IPC: C07D249/12 , C07D403/04 , C07D403/12 , C07D401/04 , C07D401/12 , A61K31/53 , A61K31/4196 , A61P35/00 , C07D253/075 , A61K45/06
Abstract: The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10239861B2
公开(公告)日：2019-03-26
申请号：US15643801
申请日：2017-07-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Daniel J. Burdick , Alexandre Cote , Martin Duplessis , Christopher G. Nasveschuk , Alexander M. Taylor
IPC: C07D401/12 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D405/12 , A61K31/501 , A61K31/55 , A61K45/06 , C07D451/04
Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein R1-R3 have any of the values defined in the specification. The compounds and salts are useful for treating PCAF mediated disorders and/or GCN5 mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as and methods of using said compounds, salts, or compositions in the treatment of various disorders.
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20180086720A1
公开(公告)日：2018-03-29
申请号：US15686028
申请日：2017-08-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor
IPC: C07D237/20 , C07D401/12 , C07D401/04 , C07D487/04 , C07D403/04 , C07D487/08 , C07D498/10 , C07D471/10 , C07D403/14 , C07D413/12 , C07D403/12 , C07D413/14 , C07D405/14 , C07D417/14 , C07D237/22 , C07D451/02 , C07D413/04
CPC classification number: C07D237/20 , A61K31/337 , A61K31/437 , A61K31/501 , A61K45/06 , C07D237/22 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/08 , C07D498/10 , A61K2300/00
Abstract: The present invention relates to compounds of formula (I): and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.
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