公开(公告)号：US20160331800A1

公开(公告)日：2016-11-17

申请号：US15072039

申请日：2016-03-16

Applicant: California Institute of Technology

Inventor： Blake Farrow ,  James R. Heath

IPC: A61K38/00 ,  A61K47/48 ,  A61K38/12 ,  C07K7/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07B59/00 ,  A61K38/06

CPC classification number: A61K38/005 ,  A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07B2200/05 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  C07K2319/01 ,  C07K2319/70 ,  G01N33/531 ,  G01N2333/33 ,  G06F19/12 ,  Y02A50/469

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

Abstract translation: 本申请提供了稳定的基于肽的肉毒杆菌神经毒素（BoNT）血清型A捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代珠粒原位点击化学制备BoNT血清型A捕获剂的方法。

公开(公告)号：US20240337665A1

公开(公告)日：2024-10-10

申请号：US18335819

申请日：2023-06-15

Applicant: Regeneron Pharmaceuticals, Inc. ,  California Institute of Technology

Inventor： Heather Agnew ,  Bert Tsunyin Lai ,  Suresh Mark Pitram ,  Blake Farrow ,  James R. Heath ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das

IPC: G01N33/68 ,  C07K7/06 ,  C07K14/54

CPC classification number: G01N33/6869 ,  C07K7/06 ,  C07K14/54

Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US11723944B2

公开(公告)日：2023-08-15

申请号：US17322493

申请日：2021-05-17

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: A61K38/00 ,  C07B59/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08 ,  G16B5/00

CPC classification number: A61K38/005 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  G01N33/531 ,  A61K38/00 ,  C07B2200/05 ,  C07K2319/01 ,  C07K2319/70 ,  G01N2333/33 ,  G16B5/00 ,  Y02A50/30

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20210369807A1

公开(公告)日：2021-12-02

申请号：US17322493

申请日：2021-05-17

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: A61K38/00 ,  C07B59/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US11007245B2

公开(公告)日：2021-05-18

申请号：US15420596

申请日：2017-01-31

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: C07B59/00 ,  A61K38/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08 ,  G16B5/00

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US10975123B2

公开(公告)日：2021-04-13

申请号：US15680171

申请日：2017-08-17

Applicant: California Institute of Technology

Inventor： Kaycie Deyle ,  Blake Farrow ,  James R. Heath

IPC: A61K38/00 ,  C07K7/06 ,  G01N33/573 ,  C07K7/00 ,  C12N9/12 ,  G01N33/574 ,  C07K14/00

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.