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公开(公告)号：US6063563A
公开(公告)日：2000-05-16
申请号：US81926
申请日：1998-05-20
IPC分类号： C12N15/09 , A61K39/12 , A61K48/00 , B01L3/00 , C12Q1/68 , C12Q1/70 , G01N33/483 , G01N33/50 , G01N35/00 , G01N35/02 , C07H21/00
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. An apparatus and process is described which forms individual, separately sealed and connected sample containers from a flexible hollow tubing segment connected to a fluid donation container. The tubing segment is sealed at spaced-apart intervals along its length, with tubing segment portions in the intervals between the seals defining containers, each of which holds a portion of a plasma sample. The contents of the containers are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, X.sub.rcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译： 提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。 描述了一种从与流体供给容器连接的柔性中空管段形成单独的，分开的密封和连接的样品容器的装置和方法。 管段沿着其长度以间隔间隔密封，密封件之间的间隔中的管段部分限定容器，每个容器保持一部分等离子体样品。 容器的内容物形成池，其随后通过诸如PCR的高灵敏度测试来检测病毒污染。根据将来自每个捐赠的样品映射到N-末端的每个元件的算法来测试池。 三维矩阵或网格。 矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。 从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。 所有的子项目在一个PCR测试周期中进行测试。 根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。
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12.发明授权
公开(公告)号：US6057105A
公开(公告)日：2000-05-02
申请号：US987326
申请日：1997-12-09
申请人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
发明人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Methods for detecting metastasis of melanoma and breast cancer cells, detecting subclinical metastasis, and monitoring treatment are disclosed. Kits for use in such methods also are disclosed. The methods provide for the detection of nucleic acids corresponding to multiple melanoma or breast cancer specific markers using template dependent amplification processes. Methods using multiple markers provide increased sensitivity over existing methods.
摘要翻译： 公开了检测黑素瘤和乳腺癌细胞转移的方法，检测亚临床转移和监测治疗方法。 用于这些方法的试剂盒也被公开。 该方法提供使用模板依赖性扩增方法检测对应于多种黑素瘤或乳腺癌特异性标志物的核酸。 使用多个标记的方法比现有方法提高了灵敏度。
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公开(公告)号：US07676493B2
公开(公告)日：2010-03-09
申请号：US11364060
申请日：2006-02-28
申请人： Michael J. Pizzo , Chris A. Suver , Pablo Castro , Alyssa Heather Henry , Andrew J. Conrad , Subramanian Muralidhar , Benjamin Albahari , Jose A. Blakeley
发明人： Michael J. Pizzo , Chris A. Suver , Pablo Castro , Alyssa Heather Henry , Andrew J. Conrad , Subramanian Muralidhar , Benjamin Albahari , Jose A. Blakeley
CPC分类号： G06F17/30607
摘要： The claimed subject matter relates to an architecture that can facilitate an incremental approach to an Object-Relational mapping solution. The architecture can provide a rich data model that is defined at the value layer. The rich data model can expose an interface that conforms with the interfaces exposed by common storage-specific data providers. The architecture can extend common storage-specific data provider to support common command representations, and provide entity services that work in terms of the rich data model as well as object services such as identity management, updating and change tracking.
摘要翻译： 所要求保护的主题涉及可以促进对象关系映射解决方案的增量方法的体系结构。 该架构可以提供在值层定义的丰富的数据模型。 丰富的数据模型可以暴露符合常见存储特定数据提供者所暴露接口的接口。 该架构可以扩展常见的特定于存储的数据提供者，以支持通用命令表示，并提供在富数据模型以及对象服务（如身份管理，更新和更改跟踪）方面工作的实体服务。
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公开(公告)号：US20080065590A1
公开(公告)日：2008-03-13
申请号：US11470940
申请日：2006-09-07
IPC分类号： G06F17/30
CPC分类号： G06F16/24561 , G06F16/24542 , G06F16/24547
摘要： Lightweight query processing for in-memory or cache memory data structures, such as DataSet, is provided. Prior to executing a query over an in-memory data structure, a query processor determines whether any benefits can be obtained by first optimizing the query execution strategy. Additionally, one or more bail out points can be applied to the optimization analysis to further enhance query execution speed for circumstances where optimization is unlikely to provide significant performance benefits. The lightweight query processing techniques can be supported in any framework for processing or formulating queries of in-memory data structures, such as language integrated query (LINQ) queries.
摘要翻译： 提供了内存或高速缓冲存储器数据结构（如DataSet）的轻量级查询处理。 在通过内存数据结构执行查询之前，查询处理器通过首先优化查询执行策略来确定是否可以获得任何益处。 此外，一个或多个保释点可以应用于优化分析，以进一步增强查询执行速度，以便优化不太可能提供显着的性能优势的情况。 可以在任何框架中支持轻量级查询处理技术，以处理或制定诸如语言集成查询（LINQ）查询的内存中数据结构的查询。
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公开(公告)号：USH1960H1
公开(公告)日：2001-06-05
申请号：US08893869
申请日：1997-07-11
IPC分类号： G01N3500
摘要： An automated system and process is provided for pooling samples from a multiplicity of blood or plasma donations for subsequent testing to uniquely identify any such blood or plasma donations which may be infected with a particular virus. The system includes an autosampler needle which is directly inserted into a blood or plasma sample aliquot container in order to withdraw an aliquot portion of the contents for forming a sample pool with aliquot portions of other blood or plasma samples. The autosampler comprises a tubular piercing member having a hollow interior bore and a tubular shroud surrounding the piercing member.
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公开(公告)号：US5780222A
公开(公告)日：1998-07-14
申请号：US778610
申请日：1997-01-06
IPC分类号： C12N15/09 , A61K39/12 , A61K48/00 , B01L3/00 , C12Q1/68 , C12Q1/70 , G01N33/483 , G01N33/50 , G01N35/00 , G01N35/02 , C07H21/00 , C12P19/34
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. An apparatus and process is described which forms individual, separately sealed and connected sample containers from a flexible hollow tubing segment connected to a fluid donation container. The tubing segment is sealed at spaced-apart intervals along its length, with tubing segment portions in the intervals between the seals defining containers, each of which holds a portion of a plasma sample. The contents of the containers are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, X.sub.rcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译： 提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。 描述了一种从与流体供给容器连接的柔性中空管段形成单独的，分开的密封和连接的样品容器的装置和方法。 管段沿着其长度以间隔间隔密封，密封件之间的间隔中的管段部分限定容器，每个容器保持一部分等离子体样品。 将容器的内容物形成池，随后通过诸如PCR的高灵敏度试验来测试病毒污染。 根据每个捐赠的样本被映射到N维矩阵或网格的每个元素的算法来测试池。 矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。 从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。 所有的子项目在一个PCR测试周期中进行测试。 根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。
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