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11.发明申请THERAPEUTIC COMBINATION COMPRISING A CDKS INHIBITOR AND AN ANTINEOPLASTIC AGENT 有权包含CDKS抑制剂和抗原药物的治疗组合公开(公告)号：US20110312909A1
公开(公告)日：2011-12-22
申请号：US13055541
申请日：2009-07-29
IPC分类号： A61K31/519 , A61K31/7068 , A61B19/02 , A61P35/00
CPC分类号： A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of alkylating or alkylating-like agents, antimetabolite agents and topoisomerase I inhibitors, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
摘要翻译： 本发明提供治疗组合，其包含（a）如说明书中所述的式（I）化合物和（b）一种或多种抗肿瘤剂，其选自烷基化或烷基化样试剂，抗代谢剂和拓扑异构酶 I抑制剂，其中活性成分在每种情况下以游离形式或以药学上可接受的盐或其任何水合物的形式存在。
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公开(公告)号：US20050038112A1
公开(公告)日：2005-02-17
申请号：US10489508
申请日：2002-09-06
申请人： Nicola Mongelli , Maria Menichincheri , Marina Ciomei , Cesare Gennari , Joachim Telser , Raphael Beumer
发明人： Nicola Mongelli , Maria Menichincheri , Marina Ciomei , Cesare Gennari , Joachim Telser , Raphael Beumer
IPC分类号： C07D233/58 , A61K31/122 , A61K31/215 , A61K31/22 , A61K31/351 , A61K31/4172 , A61K31/4178 , A61K31/421 , A61K31/426 , A61K31/4402 , A61K31/7056 , A61P35/00 , A61P35/02 , C07B61/00 , C07C67/29 , C07C69/013 , C07C69/16 , C07C69/28 , C07C69/618 , C07D213/55 , C07D233/54 , C07D233/90 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/24 , C07D277/30 , C07D309/10 , C07D405/12 , C07H15/26 , C07C69/74 , A61K31/12 , C07C49/293
CPC分类号： C07D263/34 , C07C69/013 , C07C69/618 , C07C2602/32 , C07D233/90 , C07D277/30
摘要： There are provided sarcodictyin derivatives or pharmaceutically acceptable salts thereof, which are characterized by a simplified chemical structure and have anti-tumor activity. A process for their preparation, the pharmaceutical compositions containing them, and their use in the prevention, control and treatment of cancer are also provided.
摘要翻译： 提供了莽草苷衍生物或其药学上可接受的盐，其特征在于化学结构简单并具有抗肿瘤活性。 还提供了其制备方法，含有它们的药物组合物及其在预防，控制和治疗癌症中的用途。
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公开(公告)号：US06187758B1
公开(公告)日：2001-02-13
申请号：US09367848
申请日：1999-08-27
申请人： Cinzia Portello , Emanuele Arlandini , Umberto Breme , Anna Luisa Colombo , Giuliano Franchi , Giuliano Oronzo , Marco Tató , Luisa Garofano , Marina Ciomei
发明人： Cinzia Portello , Emanuele Arlandini , Umberto Breme , Anna Luisa Colombo , Giuliano Franchi , Giuliano Oronzo , Marco Tató , Luisa Garofano , Marina Ciomei
IPC分类号： A61K3171
CPC分类号： C07H15/252
摘要： An anthracycline glycoside of formula I wherein R is one of the two following residues: or a pharmaceutically acceptable salt thereof.
摘要翻译： 式I的蒽环素糖苷，其中R是以下两个残基之一：或其药学上可接受的盐。
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14.发明授权
公开(公告)号：US5593976A
公开(公告)日：1997-01-14
申请号：US426130
申请日：1995-04-21
申请人： Nicola Mongelli , Giovanni Biasoli , Alfredo Paio , Maria Grandi , Marina Ciomei
发明人： Nicola Mongelli , Giovanni Biasoli , Alfredo Paio , Maria Grandi , Marina Ciomei
IPC分类号： A61K31/40 , A61K31/7056 , A61P3/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/325 , C07D207/335 , C07D207/34 , C07D403/02 , C07D403/14
CPC分类号： C07D207/34
摘要： The invention relates to ureido derivatives of substituted pyrroles of formula ##STR1## wherein each of m and n, being the same, is an integer of 1 to 3; W is oxygen of sulphur;each of the B groups, which are the same, isa) a saturated or unsaturated, carbocyclic or condensed carbocyclic ring substituted by one or more acid groups;b) a saturated or unsaturated, heteromonocyclic or heterobicyclic ring, containing one or more heteroatoms chosen from nitrogen, oxygen and sulphur, substituted by one or more acid groups;c) a pyranyl or furanyl sugar residue substituted by one or more acid groups; ord) a --CH.sub.2 (CHA).sub.8 CH.sub.2 A group, wherein each A group, being the same or different, is an acid group and r is 0, 1 or 2;and the pharmaceutically acceptable salts thereof, which are useful as angiogenesis inhibitors.
摘要翻译： 本发明涉及式（I）的取代吡咯的脲基衍生物，其中m和n各自相同，为1〜3的整数; W是硫的氧; 每个B基团相同，是a）被一个或多个酸基团取代的饱和或不饱和的碳环或稠合的碳环; b）饱和或不饱和的异单环或杂双环，其含有一个或多个选自氮，氧和硫的杂原子，被一个或多个酸基取代; c）被一个或多个酸基取代的吡喃基或呋喃基糖残基; 或d）-CH 2（CHA）8 CH 2 A基团，其中每个A基团相同或不同，为酸基团，r为0,1或2; 及其药学上可接受的盐，其可用作血管生成抑制剂。
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公开(公告)号：US08912194B2
公开(公告)日：2014-12-16
申请号：US13130903
申请日：2009-11-23
申请人： Marina Ciomei , Angela Scaburri
发明人： Marina Ciomei , Angela Scaburri
IPC分类号： A61K31/519
CPC分类号： A61K31/519
摘要： The invention provides a low molecular weight ATP-competitive CDK inhibitor for use in the treatment of mesothelioma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
摘要翻译： 本发明提供了用于治疗间皮瘤的低分子量ATP竞争性CDK抑制剂。 该化合物可与一种或多种细胞毒性或细胞抑制剂一起施用。
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公开(公告)号：US20140080807A1
公开(公告)日：2014-03-20
申请号：US14116512
申请日：2012-05-07
IPC分类号： A61K31/5377 , A61K31/496 , C07D401/12 , C07D231/56 , A61K45/06 , A61K31/454 , C07D295/185 , C07D405/12 , C07D403/12 , C07D295/155 , A61K31/416
CPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D295/155 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C12N9/12 , C12Y207/10001
摘要： The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及调节蛋白激酶活性的取代吲唑化合物，因此可用于治疗由脱蛋白激酶活性引起的疾病，如癌症。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物的方法。
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公开(公告)号：US08580793B2
公开(公告)日：2013-11-12
申请号：US13256467
申请日：2010-03-15
IPC分类号： A61K31/497 , C07D491/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention provides a low molecular weight ATP-competitive CDK inhibitor and TRKA inhibitor of formula (I) for use in the treatment of thymoma and thymic carcinoma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
摘要翻译： 本发明提供了用于治疗胸腺瘤和胸腺癌的式（I）的低分子量ATP竞争性CDK抑制剂和TRKA抑制剂。 该化合物可与一种或多种细胞毒性或细胞抑制剂一起施用。
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18.发明授权Therapeutic combination comprising a CDKS inhibitor and an antineoplastic agent 有权包含CDKS抑制剂和抗肿瘤剂的治疗组合公开(公告)号：US08518930B2
公开(公告)日：2013-08-27
申请号：US13055541
申请日：2009-07-29
IPC分类号： A01N55/02 , A61K31/555
CPC分类号： A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of alkylating or alkylating-like agents, antimetabolite agents and topoisomerase I inhibitors, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
摘要翻译： 本发明提供治疗组合，其包含（a）如说明书中所述的式（I）化合物和（b）一种或多种抗肿瘤剂，其选自烷基化或烷基化样试剂，抗代谢剂和拓扑异构酶 I抑制剂，其中活性成分在每种情况下以游离形式或以药学上可接受的盐或其任何水合物的形式存在。
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公开(公告)号：US20120077819A1
公开(公告)日：2012-03-29
申请号：US13256467
申请日：2010-03-15
IPC分类号： A61K31/519 , A61P35/00 , C07D487/06
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention provides a low molecular weight ATP-competitive CDK inhibitor and TRKA inhibitor of formula (I) for use in the treatment of thymoma and thymic carcinoma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
摘要翻译： 本发明提供了用于治疗胸腺瘤和胸腺癌的式（I）的低分子量ATP竞争性CDK抑制剂和TRKA抑制剂。 该化合物可与一种或多种细胞毒性或细胞抑制剂一起施用。
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公开(公告)号：US20110224222A1
公开(公告)日：2011-09-15
申请号：US13130903
申请日：2009-11-23
申请人： Marina Ciomei , Angela Scaburri
发明人： Marina Ciomei , Angela Scaburri
IPC分类号： A61K31/497 , C07D487/04 , A61P35/00
CPC分类号： A61K31/519
摘要： The invention provides a low molecular weight ATP-competitive CDK inhibitor for use in the treatment of mesothelioma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
摘要翻译： 本发明提供了用于治疗间皮瘤的低分子量ATP竞争性CDK抑制剂。 该化合物可与一种或多种细胞毒性或细胞抑制剂一起施用。
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