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公开(公告)号：US08642773B2
公开(公告)日：2014-02-04
申请号：US13262266
申请日：2010-04-01
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Onions , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Onions , Catherine Elisabeth Charron
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D401/12 , A61K31/24 , A61K31/351 , A61K31/4439
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers, which is an inhibitor of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其包括所有立体异构体和互变异构体，其是p38丝裂原活化蛋白激酶的抑制剂（本文称为p38 MAP激酶抑制剂），特别是 其α和γ激酶亚型及其在治疗中的应用，包括药物组合，特别是治疗炎性疾病，包括肺部炎症性疾病如COPD。
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公开(公告)号：US20130040995A1
公开(公告)日：2013-02-14
申请号：US13639887
申请日：2011-04-08
申请人： John King-Underwood , Kazuhiro Ito , Peter Strong , William Garth Rapeport , Catherine Elisabeth Charron , Peter John Murray , Jonathan Gareth Williams , Stuart Thomas Onions
发明人： John King-Underwood , Kazuhiro Ito , Peter Strong , William Garth Rapeport , Catherine Elisabeth Charron , Peter John Murray , Jonathan Gareth Williams , Stuart Thomas Onions
IPC分类号： C07D401/12 , A61P11/00 , A61P11/06 , A61P17/00 , A61P35/00 , A61P1/04 , A61P19/02 , A61P1/18 , A61P35/04 , A61K31/4439 , A61P17/06
CPC分类号： C07D401/12
摘要： There is provided inter alia a compound of formula (I): wherein R1, J, Ar, L, X, R3 and R4 are as defined in the specification, for use in the treatment of inflammatory disorders.
摘要翻译： 尤其提供式（I）化合物：其中R 1，J，Ar，L，X，R 3和R 4如说明书中所定义，用于治疗炎症性疾病。
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公开(公告)号：US08299074B2
公开(公告)日：2012-10-30
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/5377 , A61K31/505 , A61K31/445 , A61K31/4427 , C07D413/14 , C07D403/02 , C07D213/02 , C07D211/06
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译： 本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中 的炎性疾病，包括肺的炎性疾病，如COPD。
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公开(公告)号：US08299073B2
公开(公告)日：2012-10-30
申请号：US13133998
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
IPC分类号： A61K31/5377 , A61K31/505 , A61K31/445 , A61K31/4427 , A61K31/496 , C07D413/14 , C07D403/02 , C07D213/02 , C07D211/06 , C07D401/02 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其包括其所有的立体异构体，互变异构体和同位素衍生物，其是p38丝裂原活化蛋白激酶的抑制剂（本文称为p38 MAP激酶抑制剂）， 特别是其α和γ激酶亚型，以及它们在治疗中的用途，包括药物组合，特别是治疗炎症性疾病，包括肺炎性疾病如COPD。
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公开(公告)号：US20110312963A1
公开(公告)日：2011-12-22
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/4439 , C07D405/14 , C07D413/14 , C07D401/14 , C07D403/12 , A61K31/5377 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61P11/00 , A61P11/06 , A61P17/00 , A61P37/08 , A61P11/02 , A61P27/02 , A61P27/14 , A61P17/06 , A61P1/04 , A61P29/00 , A61P19/02 , A61P1/18 , A61P3/00 , A61P35/00 , A61P35/04 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD
摘要翻译： 本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中 的炎性疾病，包括肺的炎性疾病，如COPD
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公开(公告)号：US20130123260A1
公开(公告)日：2013-05-16
申请号：US13805485
申请日：2011-06-17
IPC分类号： C07D401/12 , A61K31/4245 , C07D405/14 , A61K31/5377 , C07D403/12 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D413/14 , A61K31/506 , A61K31/4439 , C07D401/14
CPC分类号： A61K31/4439 , A61K31/415 , A61K31/4155 , A61K31/4245 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/713 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C12Q1/485 , G01N2333/912 , G01N2440/14
摘要： The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of rhinovirus infection, methods of treating or preventing rhinovirus infection employing said compounds or pharmaceutical composition comprising the same. The disclosure also relates to compounds of formula (I) for use in the treatment or prophylaxis of exacerbation of respiratory disorders (such as asthma, COPD, bronchitis and/or cystic fibrosis) by rhinovirus infection.
摘要翻译： 本公开涉及用于治疗或预防鼻病毒感染的式（I）化合物，使用所述化合物或包含其的药物组合物治疗或预防鼻病毒感染的方法。 本公开还涉及通过鼻病毒感染用于治疗或预防呼吸系统疾病（例如哮喘，COPD，支气管炎和/或囊性纤维化）恶化的式（I）化合物。
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17.发明申请公开(公告)号：US20130102607A1
公开(公告)日：2013-04-25
申请号：US13805552
申请日：2011-06-17
IPC分类号： C07D413/14 , C07D403/12 , C07D401/14 , C07D401/12 , C07D405/14
CPC分类号： C07D413/14 , A61K31/415 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14
摘要： Medicinal use The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of respiratory syncitial virus (RSV) infection in particular viral exacerbation of a respiratory disorder such as bronchitis, asthma, COPD and/or cystic fibrosis, methods of treating or preventing RSV infection employing said compounds or pharmaceutical composition comprising the same.
摘要翻译： 医药用途本公开涉及用于治疗或预防呼吸道合胞病毒（RSV）感染，特别是呼吸系统疾病例如支气管炎，哮喘，COPD和/或囊性纤维化的病毒性恶化的式（I）化合物，方法 使用所述化合物或包含其的药物组合物治疗或预防RSV感染。
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18.发明授权Ureido-pyrazole derivatives for use in the treatment of respiratory syncitial virus (RSV) infection 有权脲基吡唑衍生物用于治疗呼吸道合胞病毒（RSV）感染公开(公告)号：US09079893B2
公开(公告)日：2015-07-14
申请号：US13805552
申请日：2011-06-17
IPC分类号： C07D401/02 , C07D413/14 , A61K31/415 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14
CPC分类号： C07D413/14 , A61K31/415 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14
摘要： Medicinal use The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of respiratory syncitial virus (RSV) infection in particular viral exacerbation of a respiratory disorder such as bronchitis, asthma, COPD and/or cystic fibrosis, methods of treating or preventing RSV infection employing said compounds or pharmaceutical composition comprising the same.
摘要翻译： 医药用途本公开涉及用于治疗或预防呼吸道合胞病毒（RSV）感染，特别是呼吸系统疾病例如支气管炎，哮喘，COPD和/或囊性纤维化的病毒性恶化的式（I）化合物，方法 使用所述化合物或包含其的药物组合物治疗或预防RSV感染。
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19.发明申请公开(公告)号：US20170312279A1
公开(公告)日：2017-11-02
申请号：US15636730
申请日：2017-06-29
申请人： Kazuhiro Ito , Catherine Elisabeth Charron , John King-Underwood , Stuart Thomas Onions , Alistair Ian Lonshaw
发明人： Kazuhiro Ito , Catherine Elisabeth Charron , John King-Underwood , Stuart Thomas Onions , Alistair Ian Lonshaw
IPC分类号： A61K31/506 , A61K31/351 , A61K9/00 , A61K31/215 , C07D403/12 , A61K45/06
CPC分类号： A61K31/506 , A61K9/0075 , A61K31/215 , A61K31/351 , A61K45/06 , C07D403/12 , A61K2300/00
摘要： There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.
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公开(公告)号：US10093659B2
公开(公告)日：2018-10-09
申请号：US15298431
申请日：2016-10-20
IPC分类号： C07D405/06 , A61K31/496 , A61K45/06
摘要： This invention relates to a compound, as defined in the specification and as represented by the compound of formula (I): useful in the treatment of mycoses, to compositions containing it and its use in therapy.
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