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11.发明申请Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas 审中-公开使用芳基和杂芳基取代的杂环脲抑制p38激酶活性公开(公告)号：US20080300281A1
公开(公告)日：2008-12-04
申请号：US12181032
申请日：2008-07-28
申请人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/4439 , A61K31/415 , A61K31/4427 , A61K31/381 , A61P19/02
CPC分类号： A61K31/381 , A61K31/415 , A61K31/4427 , A61K31/4439 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗癌症以外的细胞因子介导的疾病和除了癌症以外的蛋白水解酶介导的疾病以及用于这种治疗的药物组合物中的用途。
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12.发明申请公开(公告)号：US20060019990A1
公开(公告)日：2006-01-26
申请号：US11158048
申请日：2005-06-22
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D213/40
摘要： The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及含有用于这种治疗的这些尿素的药物组合物。
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公开(公告)号：US06943172B2
公开(公告)日：2005-09-13
申请号：US10349176
申请日：2003-01-23
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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14.发明申请INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS 审中-公开使用对称和非对称二苯醚类尿素抑制P38激酶公开(公告)号：US20090093526A1
公开(公告)日：2009-04-09
申请号：US11932397
申请日：2007-10-31
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/40 , A61K31/44 , C07D207/36 , C07D213/04 , A61P19/02
CPC分类号： A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途，以及用于这种治疗的药物组合物。
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公开(公告)号：US20050192304A1
公开(公告)日：2005-09-01
申请号：US11107793
申请日：2005-04-18
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D43/02
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症，例如冠心病。
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公开(公告)号：US06924290B2
公开(公告)日：2005-08-02
申请号：US10349177
申请日：2003-01-23
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号：US20100137313A1
公开(公告)日：2010-06-03
申请号：US12572436
申请日：2009-10-02
申请人： Ann Boriack-Sjodin , Daniel Robert Carcanague , Daemian David Dussault , Holia Hatoum-Mokdad , Kenneth Gregory Hull , Georgine Ioannidis , John Irvin Manchester , Helen Maureen McGuire , David Charles McKinney , Suzanne Stokes
发明人： Ann Boriack-Sjodin , Daniel Robert Carcanague , Daemian David Dussault , Holia Hatoum-Mokdad , Kenneth Gregory Hull , Georgine Ioannidis , John Irvin Manchester , Helen Maureen McGuire , David Charles McKinney , Suzanne Stokes
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/506 , C07D413/14
CPC分类号： C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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18.发明申请INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 失效使用ARYL和HETEROARYL取代的杂环类URAAS对RAF激酶的抑制作用公开(公告)号：US20080009527A1
公开(公告)日：2008-01-10
申请号：US11768533
申请日：2007-06-26
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/4439 , A61K31/415 , A61P35/00 , C07D401/12 , C07D405/04 , C07D231/38 , A61K31/443
CPC分类号： C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,
摘要翻译： 用raf激酶介导的肿瘤治疗方法，用取代的脲化合物和这些化合物本身，
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公开(公告)号：US20050209261A1
公开(公告)日：2005-09-22
申请号：US11111704
申请日：2005-04-22
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号：US20120302587A1
公开(公告)日：2012-11-29
申请号：US13567863
申请日：2012-08-06
IPC分类号： A61K31/506 , C07D401/12 , A61K31/517 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P7/02 , A61P11/06 , A61P27/06 , A61P19/08 , A61P15/00 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症，例如冠心病。
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