Detection of gleevec resistant mutations
    11.
    发明授权
    Detection of gleevec resistant mutations 失效
    检测gleevec抗性突变

    公开(公告)号:US07416873B2

    公开(公告)日:2008-08-26

    申请号:US11873985

    申请日:2007-10-17

    IPC分类号: C12N9/12 C07K1/00

    摘要: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

    摘要翻译: 本发明涉及分离的多肽,其包含由突变的功能性Ab1激酶结构域组成的氨基酸序列,所述突变的功能性激酶结构域对N- [4-甲基-3-(4-吡啶基) 吡啶-3-基 - 嘧啶-2-基氨基) - 苯基] -4-(4-甲基 - 哌嗪-1-基甲基) - 苯甲酰胺或其盐,用于筛选抑制酪氨酸激酶的化合物 这种多肽的活性,编码这种多肽的核酸分子,重组载体和包含此类核酸分子的宿主细胞,以及这种核酸分子在制备这些多肽中的用途,用于筛选抑制酪氨酸激酶的化合物 这些多肽的活性。

    DETECTION OF GLEEVEC RESISTANCE
    12.
    发明申请
    DETECTION OF GLEEVEC RESISTANCE 审中-公开
    检测GLEEVEC抗性

    公开(公告)号:US20130273542A1

    公开(公告)日:2013-10-17

    申请号:US13924369

    申请日:2013-06-21

    IPC分类号: C12Q1/68

    摘要: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

    摘要翻译: 本发明涉及分离的多肽,其包含由突变的功能性Ab1激酶结构域组成的氨基酸序列,所述突变的功能性激酶结构域对N- [4-甲基-3-(4-吡啶基) 吡啶-3-基 - 嘧啶-2-基氨基) - 苯基] -4-(4-甲基 - 哌嗪-1-基甲基) - 苯甲酰胺或其盐,用于筛选抑制酪氨酸激酶的化合物 这种多肽的活性,编码这种多肽的核酸分子,重组载体和包含此类核酸分子的宿主细胞,以及这种核酸分子在制备这些多肽中的用途,用于筛选抑制酪氨酸激酶的化合物 这些多肽的活性。

    DETECTION OF GLEEVEC RESISTANCE
    13.
    发明申请
    DETECTION OF GLEEVEC RESISTANCE 失效
    检测GLEEVEC抗性

    公开(公告)号:US20080305492A1

    公开(公告)日:2008-12-11

    申请号:US12178926

    申请日:2008-07-24

    IPC分类号: C12Q1/68 C12Q1/48

    摘要: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

    摘要翻译: 本发明涉及分离的多肽,其包含由突变的功能性Ab1激酶结构域组成的氨基酸序列,所述突变的功能性激酶结构域对N- [4-甲基-3-(4-吡啶基) 吡啶-3-基 - 嘧啶-2-基氨基) - 苯基] -4-(4-甲基 - 哌嗪-1-基甲基) - 苯甲酰胺或其盐,用于筛选抑制酪氨酸激酶的化合物 这种多肽的活性,编码这种多肽的核酸分子,重组载体和包含此类核酸分子的宿主细胞,以及这种核酸分子在制备这些多肽中的用途,用于筛选抑制酪氨酸激酶的化合物 这些多肽的活性。

    DETECTION OF GLEEVEC RESISTANT MUTATIONS
    14.
    发明申请
    DETECTION OF GLEEVEC RESISTANT MUTATIONS 失效
    检测GLEEVEC抗性突变

    公开(公告)号:US20080090300A1

    公开(公告)日:2008-04-17

    申请号:US11873985

    申请日:2007-10-17

    IPC分类号: G01N33/68

    摘要: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

    摘要翻译: 本发明涉及分离的多肽,其包含由突变的功能性Ab1激酶结构域组成的氨基酸序列,所述突变的功能性激酶结构域对N- [4-甲基-3-(4-吡啶基) 吡啶-3-基 - 嘧啶-2-基氨基) - 苯基] -4-(4-甲基 - 哌嗪-1-基甲基) - 苯甲酰胺或其盐,用于筛选抑制酪氨酸激酶的化合物 这种多肽的活性,编码这种多肽的核酸分子,重组载体和包含此类核酸分子的宿主细胞,以及这种核酸分子在制备这些多肽中的用途,用于筛选抑制酪氨酸激酶的化合物 这些多肽的活性。

    Detection of gleevec resistant mutations

    公开(公告)号:US07326534B2

    公开(公告)日:2008-02-05

    申请号:US11524626

    申请日:2006-09-20

    摘要: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.