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    Percutaneous spinal implants and methods
    11.
    发明申请
    Percutaneous spinal implants and methods 有权
    经皮脊髓植入物和方法

    公开(公告)号：US20070049934A1

    公开(公告)日：2007-03-01

    申请号：US11356295

    申请日：2006-02-17

    申请人： Avram Edidin ,  Andrew Kohm ,  Hugues Malandain

    发明人： Avram Edidin ,  Andrew Kohm ,  Hugues Malandain

    IPC分类号： A61F2/30

    CPC分类号： A61B17/025 ,  A61B17/7065 ,  A61B2017/00557 ,  A61B2017/0256

    摘要： Apparatuses and methods for performing minimally-invasive medical procedures are described. In one embodiment, for example, an apparatus includes an elongate member having a proximal portion configured to move repeatedly between a first configuration and a second configuration. At least a section of the proximal portion is collapsed in the first configuration and is expanded in the second configuration. The elongate member has a distal portion configured to move repeatedly between a first configuration and a second configuration. At least a section of the proximal portion is collapsed in the first configuration and is expanded in the second configuration. A non-expanding central portion is positioned between the proximal portion and the distal portion. The non-expanding central portion is configured to engage adjacent spinous processes.

    摘要翻译： 描述了用于执行微创医疗程序的装置和方法。 在一个实施例中，例如，一种装置包括细长构件，该细长构件具有配置成在第一构型和第二构型之间重复移动的近侧部分。 近端部分的至少一部分在第一构造中折叠并且在第二构造中扩张。 细长构件具有构造成在第一构型和第二构造之间重复移动的远侧部分。 近端部分的至少一部分在第一构造中折叠并且在第二构造中扩张。 未膨胀的中心部分位于近端部分和远端部分之间。 非扩张中心部分构造成接合相邻的棘突。

    CELL TREATMENTS AND THERAPEUTIC REINFUSION METHODS
    12.
    发明申请
    CELL TREATMENTS AND THERAPEUTIC REINFUSION METHODS 有权

    公开(公告)号：US20220143082A1

    公开(公告)日：2022-05-12

    申请号：US17580419

    申请日：2022-01-20

    申请人： Todd Alamin ,  Avram Allan Edidin ,  Hugues Malandain ,  Healey Montague-Alamin

    发明人： Todd Alamin ,  Avram Allan Edidin ,  Hugues Malandain ,  Healey Montague-Alamin

    IPC分类号： A61K35/13 ,  C12M1/00 ,  C12N5/09

    摘要： Tumor tissue, including soft and/or bony tissue, are harvested from a subject and morcellated. The morcellated tissue is placed in a cartridge which is placed in a containment chamber of a tumor tissue processing device. Cancer cells in the morcellated tumor tissue are destroyed without destroying tumor antigens therein. These cells are destroyed cryogenically by exposing the cartridge to a cooling fluid such as liquid nitrogen, optionally with a warming cycle, and optionally with more than one freezing/thawing cycle. The treated tissue and/or cells are then extracted from the cartridge and reintroduced to the subject after they have reached a threshold condition. The treated tissue and/or cells can be reintroduced via a containment sleeve or a reimplantation bag.

    Plastically deformable inter-osseous device
    13.
    发明授权
    Plastically deformable inter-osseous device 有权
    塑性变形骨间装置

    公开(公告)号：US08641769B2

    公开(公告)日：2014-02-04

    申请号：US13809329

    申请日：2011-06-27

    申请人： Hugues Malandain

    发明人： Hugues Malandain

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4455 ,  A61B17/8852 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30018 ,  A61F2002/30377 ,  A61F2002/30579 ,  A61F2002/4475 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2220/0016 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00137 ,  A61F2310/00161 ,  A61F2310/00167 ,  A61F2310/00203

    摘要： Described here are deformable, monolithic, stabilization devices, or implants, suitable for use within bone and between bones, for instance, to fuse vertebral bodies, to repair herniated discs, or to repair spinal compression fractures. The implants are introduced into a chosen site at a first, smaller height and then plastically deformed to achieve a second, but unique, pre-selected, larger height. Variations of the device provide one or more specific larger heights. The devices are particularly suitable as intervertebral spinal fusion implants for the immobilization of adjacent vertebral bodies. Methods of deploying the implants are also described as are instruments for such deployment.Also described are variations of the device particularly suitable as sizing instruments. These versions are elastic, i.e., not plastically deformable, and may be restored to their original size. Many of the described variations include deformable regions serving as hinges. Other variations are non-monolithic or may have one or more classical hinges substituted for the deformable regions.

    摘要翻译： 这里描述的是可变形的，整体的，稳定的装置或植入物，适用于骨骼内和骨骼之间，例如使椎体融合，修复突出的椎间盘或修复脊柱压迫性骨折。 将植入物以第一较小的高度引入选定的位置，然后塑性变形以实现第二但唯一的预先选择的较大的高度。 设备的变化提供一个或多个特定的更大的高度。 该装置特别适用于固定相邻椎体的椎间融合植入物。 植入物的部署方法也被描述为这种部署的工具。 还描述了特别适合作为尺寸调节装置的装置的变型。 这些版本是弹性的，即不是塑性变形的，并且可以恢复到它们的原始尺寸。 许多描述的变型包括用作铰链的可变形区域。 其它变化是非整体的或者可以具有代替可变形区域的一个或多个经典铰链。

    Central rod connector and T-rod
    14.
    发明申请
    Central rod connector and T-rod 审中-公开
    中央杆连接器和T型杆

    公开(公告)号：US20080177327A1

    公开(公告)日：2008-07-24

    申请号：US11581831

    申请日：2006-10-17

    申请人： Hugues Malandain ,  David L. Brumfield

    发明人： Hugues Malandain ,  David L. Brumfield

    IPC分类号： A61B17/56

    CPC分类号： A61B17/7043 ,  A61B17/701 ,  A61B17/7011 ,  A61B17/7035 ,  A61B2017/7073

    摘要： Connecting devices and elongated members for orthopedic medical use are disclosed. In certain embodiments, a connecting device may include a central portion that can accommodate part of an elongated member and wings for connecting to anchor members. Such central portions can be open or closed, and such wings can be solid, e.g. rod-type structures, or can be slotted. A T-shaped elongated member is also disclosed.

    摘要翻译： 公开了用于矫形医疗用途的连接装置和细长构件。 在某些实施例中，连接装置可以包括中心部分，该中心部分可以容纳细长构件的一部分和用于连接到锚定构件的翼。 这样的中心部分可以是敞开的或闭合的，并且这样的翼可以是固体的，例如。 杆型结构，或可以开槽。 还公开了一种T形细长构件。

    Percutaneous Spinal Implants and Methods
    16.
    发明申请
    Percutaneous Spinal Implants and Methods 审中-公开
    经皮脊髓植入物及方法

    公开(公告)号：US20070276372A1

    公开(公告)日：2007-11-29

    申请号：US11625624

    申请日：2007-01-22

    申请人： Hugues Malandain ,  Avram Edidin ,  Robert Vandervelde

    发明人： Hugues Malandain ,  Avram Edidin ,  Robert Vandervelde

    IPC分类号： A61B17/58

    CPC分类号： A61B17/7065 ,  A61B2017/00557

    摘要： A method includes inserting percutaneously an implant in a first configuration between adjacent spinous processes, the implant having a first end and a second end opposite the first end, moving the first end of the implant in a first axial direction, and moving the second end of the implant in a second axial direction, opposite from the first axial direction, such that the implant is in a second configuration.

    摘要翻译： 一种方法包括经皮插入植入物在相邻棘突之间的第一构型中，所述植入物具有第一端和与第一端相对的第二端，沿着第一轴向方向移动植入物的第一端，并移动植入物的第二端 所述植入物在与所述第一轴向方向相反的第二轴向方向上，使得所述植入物处于第二构型。

    Method of manufacturing an expandable member with substantially uniform profile
    18.
    发明申请
    Method of manufacturing an expandable member with substantially uniform profile 审中-公开
    制造具有基本均匀轮廓的可扩张部件的方法

    公开(公告)号：US20070010846A1

    公开(公告)日：2007-01-11

    申请号：US11250618

    申请日：2005-10-17

    申请人： Andrea Leung ,  Hugues Malandain ,  Erika Palmer ,  Paul Sand

    发明人： Andrea Leung ,  Hugues Malandain ,  Erika Palmer ,  Paul Sand

    IPC分类号： A61M29/00

    CPC分类号： A61M29/02 ,  A61B17/3421 ,  A61B17/3478 ,  A61B90/02 ,  A61B2017/00261 ,  A61B2017/00526 ,  A61B2017/320048 ,  A61M25/1029 ,  A61M29/00

    摘要： A method includes heating a first portion of a tubular member to a first temperature greater than a temperature of a second portion of the tubular member. The first portion of the tubular member is different from the second portion of the tubular member. The tubular member is stretched after the heating such that a length of the first portion of the tubular member is associated with a width of an anulus of an intervertebral disc. After the heating and the stretching, the tubular member is disposed within a mold cavity at least until the first portion of the tubular member has a second temperature less than the first temperature and such that an outer diameter of the tubular member in a collapsed configuration is substantially constant along a longitudinal length of the tubular member.

    摘要翻译： 一种方法包括将管状构件的第一部分加热到大于管状构件的第二部分的温度的第一温度。 管状构件的第一部分不同于管状构件的第二部分。 管状构件在加热之后被拉伸，使得管状构件的第一部分的长度与椎间盘的环的宽度相关联。 在加热和拉伸之后，管状构件至少直到管状构件的第一部分具有小于第一温度的第二温度并且使得处于折叠构型的管状构件的外径为 沿管状构件的纵向长度基本上恒定。

    PLASTICALLY DEFORMABLE INTER-OSSEOUS DEVICE
    19.
    发明申请
    PLASTICALLY DEFORMABLE INTER-OSSEOUS DEVICE 有权
    塑性可变的互操作设备

    公开(公告)号：US20130123927A1

    公开(公告)日：2013-05-16

    申请号：US13809329

    申请日：2011-06-27

    申请人： Hugues Malandain

    发明人： Hugues Malandain

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4455 ,  A61B17/8852 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30018 ,  A61F2002/30377 ,  A61F2002/30579 ,  A61F2002/4475 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2220/0016 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00137 ,  A61F2310/00161 ,  A61F2310/00167 ,  A61F2310/00203

    摘要： Described here are deformable, monolithic, stabilization devices, or implants, suitable for use within bone and between bones, for instance, to fuse vertebral bodies, to repair herniated discs, or to repair spinal compression fractures. The implants are introduced into a chosen site at a first, smaller height and then plastically deformed to achieve a second, but unique, pre-selected, larger height. Variations of the device provide one or more specific larger heights. The devices are particularly suitable as intervertebral spinal fusion implants for the immobilization of adjacent vertebral bodies. Methods of deploying the implants are also described as are instruments for such deployment.Also described are variations of the device particularly suitable as sizing instruments. These versions are elastic, i.e., not plastically deformable, and may be restored to their original size. Many of the described variations include deformable regions serving as hinges. Other variations are non-monolithic or may have one or more classical hinges substituted for the deformable regions.

    摘要翻译： 这里描述的是可变形的，整体的，稳定的装置或植入物，适用于骨骼内和骨骼之间，例如使椎体融合，修复突出的椎间盘或修复脊柱压迫性骨折。 将植入物以第一较小的高度引入选定的位置，然后塑性变形以实现第二但唯一的预先选择的较大的高度。 设备的变化提供一个或多个特定的更大的高度。 该装置特别适用于固定相邻椎体的椎间融合植入物。 植入物的部署方法也被描述为这种部署的工具。 还描述了特别适合作为尺寸调节装置的装置的变型。 这些版本是弹性的，即不是塑性变形的，并且可以恢复到它们的原始尺寸。 许多描述的变型包括用作铰链的可变形区域。 其它变化是非整体的或者可以具有代替可变形区域的一个或多个经典铰链。