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公开(公告)号：US20080003214A1
公开(公告)日：2008-01-03
申请号：US11575711
申请日：2005-08-24
IPC分类号： A61K38/48 , A61K31/407 , A61K31/497 , C07D285/12 , C07D403/00 , C07D413/00 , C07D401/00 , A61P7/02 , A61K31/529
CPC分类号： A61K31/4545 , A61K31/4025 , A61K31/427 , A61K31/4412 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： Use of compounds of the formula (I) in which D, E, G, W, X, Y, T, R1 and R2 have the meaning indicated in Patent Claim 1, for the prophylaxis and/or therapy of thromboembolic diseases
摘要翻译： 其中D，E，G，W，X，Y，T，R 1和R 2的式（I）化合物具有专利中所示的含义 权利要求1，用于预防和/或治疗血栓栓塞性疾病
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公开(公告)号：US20060241111A1
公开(公告)日：2006-10-26
申请号：US10559385
申请日：2004-05-12
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , C07D413/02 , C07D417/02 , C07D409/02 , C07D403/02 , C07D405/02
CPC分类号： C07D409/12 , C07D413/12
摘要： Novel compounds of the formula (I) in which Het, R1, R2 and R3 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中Het，R 1，R 2和R 3的新型式（I）化合物具有专利权利要求1中所示的含义， 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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13.发明申请Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses 失效吡唑烷-1,2-二羧基二苯胺衍生物作为治疗血栓形成的凝血因子xa抑制剂公开(公告)号：US20060183742A1
公开(公告)日：2006-08-17
申请号：US10551559
申请日：2004-03-09
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , A61K31/4178 , A61K31/416 , C07D413/02 , C07D403/02
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中R 1，R 1，R 2和R 3具有专利权利要求1中所示的含义 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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14.发明申请Heterocyclic amides and their use treating thromboembolic diseases and tumors 审中-公开杂环酰胺及其用途治疗血栓栓塞性疾病和肿瘤公开(公告)号：US20060135515A1
公开(公告)日：2006-06-22
申请号：US10530876
申请日：2003-09-18
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D409/12 , C07D333/36 , C07D409/14 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T and R1 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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公开(公告)号：US20060084648A1
公开(公告)日：2006-04-20
申请号：US10547130
申请日：2004-01-30
申请人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
发明人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/537 , A61K31/4172 , C07D265/30 , C07D413/02
CPC分类号： C07D213/64 , C07D233/46 , C07D265/32 , C07D401/12 , C07D403/12 , C07F9/6533
摘要： Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors ocoagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新化合物，其中R 1，R 2，R 3，X和Y具有专利中所示的含义 权利要求1是抑制凝血因子Xa，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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16.发明申请2-(Phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses 审中-公开2-（苯基）-2h-吡唑-3-羧酸 - 正-4-（硫代 - 杂环基） - 苯基 - 酰胺衍生物和相应的亚氨基 - 杂环基衍生物，并涉及用作凝血因子xa和/或 用于治疗血栓的病毒公开(公告)号：US20050203127A1
公开(公告)日：2005-09-15
申请号：US10519356
申请日：2003-06-05
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , A61P7/02 , A61P9/08 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D403/12 , C07D413/14 , C07D417/12 , C07D413/02 , A61K31/423 , A61K31/4245 , A61K31/4709
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , C07D403/14 , C07D413/14 , C07D417/12 , Y02P20/55
摘要： The invention relates to the novel compounds of formula (I), wherein D, M, W, X, Y, T, R1 and R1′ are defined as in patent claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
摘要翻译： 本发明涉及新的式（I）化合物，其中D，M，W，X，Y，T，R 1和R 1定义如 本发明化合物是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US08129373B2
公开(公告)日：2012-03-06
申请号：US12817314
申请日：2010-06-17
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/497 , A61K31/444 , A61P29/00 , A61P7/02 , A61P9/10 , A61P25/06 , A61P35/00 , A61P35/04
CPC分类号： C07D413/12 , C07D207/16 , C07D207/27 , C07D211/60 , C07D211/76 , C07D213/64 , C07D213/68 , C07D223/10 , C07D241/18 , C07D265/08 , C07D265/32 , C07D267/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/02 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中D，E，G，W，X，Y，T，R 1和R 2如专利权利要求1中所定义，是凝血因子Xa的抑制剂，可用于预防和 /或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07902223B2
公开(公告)日：2011-03-08
申请号：US10486238
申请日：2002-07-12
申请人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D401/12 , C07D211/76 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1如专利权利要求1中所定义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病 并用于治疗肿瘤。
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公开(公告)号：US07579346B2
公开(公告)日：2009-08-25
申请号：US10535246
申请日：2003-10-30
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/535 , A61K31/497 , A61K31/415 , C07D413/00 , C07D409/00 , C07D231/00 , C07D333/36
CPC分类号： C07D409/12 , C07D265/32 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T，m和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗 的血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20070265259A1
公开(公告)日：2007-11-15
申请号：US11576226
申请日：2005-09-16
IPC分类号： A61K31/5377 , A61P29/00 , A61P35/00 , A61P35/04 , A61P9/00 , C07D413/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： Novel compounds of the formula (I), in which X, Y, R1, R2, R3, R4 and n have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 新的式（I）化合物，其中X，Y，R 1，R 2，R 3，R 4， n具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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