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公开(公告)号：US07732481B2
公开(公告)日：2010-06-08
申请号：US10583094
申请日：2004-11-26
IPC分类号： A61K31/4015 , C07D207/04
CPC分类号： C07D207/16 , C07D401/12
摘要： Novel compounds of the formula (I), in which R, R1, R2, R3, X, X′ and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2，R 3，X，X'和Y具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或 治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07598241B2
公开(公告)日：2009-10-06
申请号：US10543109
申请日：2004-01-08
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/535 , A61K31/5375 , A61K31/4965 , A61K31/4412 , C07D265/06 , C07D241/02 , C07D213/127 , C07D295/02
CPC分类号： C07D213/64 , C07D241/18 , C07D265/06 , C07D265/10 , C07D265/32 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/653 , C07F9/6533
摘要： Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R 1，D，X，W，Y和T具有专利权利要求（1）所述的含义， （II）是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20070123509A1
公开(公告)日：2007-05-31
申请号：US10582850
申请日：2004-11-19
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D413/02 , C07D403/02
CPC分类号： C07D213/74 , C07D211/16 , C07D211/26 , C07D211/32 , C07D211/46 , C07D211/52 , C07D211/58 , C07D213/38 , C07D239/42 , C07D295/192 , C07D333/24 , C07D401/04 , C07D409/06 , C07D409/14 , C07D487/08
摘要： Novel compounds of the formula (I) in which D, E, Q, T, X, Y, Z, Z′, R1, R4 and R4′ have the meanings indicated in patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 其中D，E，Q，T，X，Y，Z，Z'，R 1，R 4和R 4的新的式（I）化合物 > 4'具有专利权利要求1所述的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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4.发明申请N-'4-(2-imino-pyrrolidin-1-yl)phenyl!-acetamide and corresponding piperidine derivatives as factor xa inhibitors for the treatment of thrombo-embolic diseases 审中-公开N-4-（2-亚氨基 - 吡咯烷-1-基）苯基 - 乙酰胺和相应的哌啶衍生物作为因子xa抑制剂用于治疗血栓栓塞性疾病公开(公告)号：US20050176760A1
公开(公告)日：2005-08-11
申请号：US10510046
申请日：2003-03-07
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
IPC分类号： C07D211/76 , A61K31/402 , A61K31/4178 , A61K31/423 , A61K31/439 , A61K31/451 , A61K31/4725 , A61P7/02 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , C07D207/22 , C07D207/24 , C07D211/72 , C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06 , A61K31/4709 , A61K31/40 , A61K31/445
CPC分类号： C07D401/12 , C07D207/22 , C07D207/24 , C07D211/72 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, M, W, X, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，M，W，X，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防 和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050171102A1
公开(公告)日：2005-08-04
申请号：US10513451
申请日：2003-04-07
申请人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
发明人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
IPC分类号： C07D295/12 , A61K31/402 , A61K31/421 , A61K31/439 , A61K31/4418 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D221/22 , C07D223/10 , C07D237/14 , C07D241/08 , C07D241/18 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06 , C07D413/02 , A61K31/4245 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/5377
CPC分类号： C07D207/26 , C07D211/76 , C07D213/64 , C07D223/10 , C07D237/14 , C07D241/08 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06
摘要： Novel compounds of the formula I in which R, R1, R1, X are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，R 1，R 1，X 1如权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050137230A1
公开(公告)日：2005-06-23
申请号：US11059655
申请日：2005-02-17
申请人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D295/12 , A61K31/17 , A61K31/27 , A61K31/381 , A61K31/402 , A61K31/405 , A61K31/4172 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/4535 , A61K31/4545 , A61K31/495 , A61K31/497 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07C271/28 , C07C273/18 , C07C275/28 , C07C275/30 , C07C303/40 , C07C311/39 , C07C311/46 , C07C315/04 , C07C317/32 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/18 , C07D209/20 , C07D211/20 , C07D211/26 , C07D211/58 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/74 , C07D213/75 , C07D223/10 , C07D233/54 , C07D233/64 , C07D241/08 , C07D265/32 , C07D295/135 , C07D295/20 , C07D295/205 , C07D333/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/44
CPC分类号： C07D207/27 , C07C271/28 , C07C275/28 , C07C275/30 , C07C311/46 , C07C317/32 , C07C323/60 , C07C2601/02 , C07D209/20 , C07D211/20 , C07D211/58 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/75 , C07D223/10 , C07D233/64 , C07D241/08 , C07D265/32 , C07D295/135 , C07D295/205 , C07D333/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Novel compounds of the formula I in which R1, D, E, W, X and n are as defined in claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，D，E，W，X和n如权利要求1所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/或 治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07683093B2
公开(公告)日：2010-03-23
申请号：US10594024
申请日：2005-03-04
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/12 , C07D403/12
摘要： Novel compounds of the formula (I), in which R, R1, R2, R3 and R4 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2，R 3和R 4具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病， 用于治疗肿瘤。
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![1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors xa and viia for the treatment of thromboses](/abs-image/US/2007/04/26/US20070093472A1/abs.jpg.150x150.jpg)
8.发明申请1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors xa and viia for the treatment of thromboses 失效1 - [（4-乙炔基苯基）] - 2 - [（苯基）] - 吡咯烷-1,2-二甲酰胺衍生物作为凝血因子xa和viia的抑制剂用于治疗血栓形成公开(公告)号：US20070093472A1
公开(公告)日：2007-04-26
申请号：US10561227
申请日：2004-05-27
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/501 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/416 , A61K31/4025 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12
摘要： Novel compounds of the formula (I), in which R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2和R 3如专利权利要求1中所定义， 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US06943179B2
公开(公告)日：2005-09-13
申请号：US10472084
申请日：2002-02-27
申请人： Werner Mederski , Bertram Cezanne , Dieter Dorsch , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Werner Mederski , Bertram Cezanne , Dieter Dorsch , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D223/10 , A61K31/45 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07C281/06 , C07C309/66 , C07D211/76 , C07D213/64 , C07D241/08 , C07D265/32 , C07D401/04 , A61K31/4412 , A61K31/495 , C07D281/06
CPC分类号： C07C281/06
摘要： Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors
摘要翻译： 其中X，Y，Z，R，R 1，R 2和R 3的式I的新化合物如专利中所定义 权利要求1是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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![1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors Xa and VIIa for the treatment of thrombosis](/abs-image/US/2009/07/07/US07557222B2/abs.jpg.150x150.jpg)
10.发明授权1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors Xa and VIIa for the treatment of thrombosis 失效1 - [（4-乙炔基苯基）] - 2 - [（苯基）] - 吡咯烷-1,2-二甲酰胺衍生物作为凝血因子Xa和VIIa的抑制剂用于治疗血栓形成公开(公告)号：US07557222B2
公开(公告)日：2009-07-07
申请号：US10561227
申请日：2004-05-27
IPC分类号： C07D227/04
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12
摘要： Novel compounds of the formula (I), in which R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2和R 3如专利权利要求1中所定义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗 的肿瘤。
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