公开(公告)号：US10342760B2

公开(公告)日：2019-07-09

申请号：US14775539

申请日：2014-03-14

申请人： The University of British Columbia

发明人： Euan Ramsay ,  R. James Taylor ,  Colin Walsh ,  Nathan M. Belliveau ,  Pieter R. Cullis ,  Timothy Leaver ,  Andre Wild

IPC分类号： A61K31/575 ,  A61K31/7088 ,  A61K9/127 ,  C12N15/88 ,  A61K9/00 ,  A61K31/713 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/32 ,  A61K47/44 ,  A61K9/51

摘要： Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and small molecule drugs, to cells.

公开(公告)号：US20190076372A1

公开(公告)日：2019-03-14

申请号：US16184869

申请日：2018-11-08

申请人： The University of British Columbia

发明人： Colin Walsh ,  Andre Wild ,  Robert James Taylor ,  Timothy Leaver ,  Kevin Ou ,  Euan Ramsay ,  Aysha Ansari

IPC分类号： A61K9/51 ,  B01F5/02 ,  B01F3/08 ,  B01F13/00 ,  B01F13/10 ,  B01J2/06 ,  A61K31/7105

摘要： Methods and devices for making particles at small volumes.

公开(公告)号：US20160158383A1

公开(公告)日：2016-06-09

申请号：US14907507

申请日：2014-07-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Euan Ramsay ,  Robert James Taylor ,  Andre Wild ,  Timothy Leaver ,  Colin Walsh

IPC分类号： A61K47/48 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K9/5161 ,  A61K47/6939 ,  C12N15/87

摘要： Methods and devices for manufacturing polymer particles containing a therapeutic material and polymer conjugate particles comprising (a) introducing a first stream comprising a first solvent into a channel, wherein the channel has a first region adapted for flowing one or more streams introduced into the channel and a second region for mixing the contents of the one or more streams; (b) introducing a second stream comprising polymer conjugate in a second solvent into the channel to provide first and second streams flowing in the channel; (c) flowing the one or more first streams and the one or more second streams from the first region of the channel into the second region of the channel; (d) mixing of the contents of the one or more first streams and the one or more second streams flowing in the second region of the channel to provide a third stream comprising polymer conjugate nanoparticles.

摘要翻译： 用于制造含有治疗材料和聚合物缀合物颗粒的聚合物颗粒的方法和装置包括（a）将包含第一溶剂的第一流引入通道，其中所述通道具有适于流动引入到通道中的一种或多种流的第一区域， 用于混合所述一个或多个流的内容物的第二区域; （b）将包含第二溶剂中的聚合物共轭物的第二物流引入所述通道以提供在所述通道中流动的第一和第二物流; （c）使所述一个或多个第一流和所述一个或多个第二流从所述通道的所述第一区域流入所述通道的所述第二区域; （d）将所述一个或多个第一物流和在所述通道的第二区域中流动的一个或多个第二物流的内容物混合以提供包含聚合物共轭纳米颗粒的第三物流。