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公开(公告)号:US11648556B2
公开(公告)日:2023-05-16
申请号:US17061247
申请日:2020-10-01
发明人: Pieter R. Cullis , Igor V. Jigaltsev , Robert James Taylor , Timothy Leaver , Andre Wild , Nathan Maurice Belliveau
IPC分类号: A61F13/00 , B01L3/00 , A61K9/107 , A61K9/127 , B01F23/41 , B01F25/431 , B01F25/433 , B01F33/30 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/00 , A61J3/00
CPC分类号: B01L3/50273 , A61J3/00 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/0002 , B01F23/41 , B01F25/431 , B01F25/4331 , B01F33/30 , B01L3/502715 , B01F25/431971 , B01L2200/0605 , B01L2200/0647 , B01L2300/06 , B01L2300/0848 , B01L2300/0867 , B01L2300/18 , Y10T428/2982
摘要: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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公开(公告)号:US10688456B2
公开(公告)日:2020-06-23
申请号:US16102518
申请日:2018-08-13
发明人: Andre Wild , Timothy Leaver , Robert James Taylor
摘要: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
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公开(公告)号:US10159652B2
公开(公告)日:2018-12-25
申请号:US15029993
申请日:2014-10-16
发明人: Colin Walsh , Andre Wild , Robert James Taylor , Timothy Leaver , Kevin Ou , Euan Ramsay , Aysha Ansari
摘要: Methods and devices for making particles at small volumes.
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公开(公告)号:US20180280970A1
公开(公告)日:2018-10-04
申请号:US15927925
申请日:2018-03-21
发明人: Pieter R. Cullis , Igor V. Jigaltsev , Robert James Taylor , Timothy Leaver , Andre Wild , Nathan Maurice Belliveau
IPC分类号: B01L3/00 , B01F5/06 , A61J3/00 , A61K9/107 , A61K9/127 , A61K9/14 , A61K31/704 , B01F13/00 , B01F3/08 , A61K49/00 , A61K47/44
摘要: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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公开(公告)号:US20180111830A1
公开(公告)日:2018-04-26
申请号:US15796646
申请日:2017-10-27
发明人: Andre Wild , Timothy Leaver , Colin Walsh , Gesine Heuck , Anitha Thomas , Aysha Ansari , Kevin Ou , Robert James Taylor , Euan Ramsay
CPC分类号: B82Y40/00 , B01F5/061 , B01F5/0644 , B01F5/0647 , B01F13/0059 , B01F13/0064 , B01F2005/0636 , B01L9/527 , B01L2200/025 , B01L2300/0816 , B81B1/00
摘要: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
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公开(公告)号:US20160235688A1
公开(公告)日:2016-08-18
申请号:US15029993
申请日:2014-10-16
发明人: Colin Walsh , Andre Wild , Robert James Taylor , Timothy Leaver , Kevin Ou , Euan Ramsay , Aysha Ansari
IPC分类号: A61K9/51 , B01F13/00 , A61K31/7105 , B01F3/08
CPC分类号: A61K9/5192 , A61K9/5123 , A61K31/7105 , B01F3/08 , B01F3/0807 , B01F3/0811 , B01F3/0861 , B01F5/02 , B01F13/0062 , B01F13/1022 , B01F2215/0032 , B01J2/06
摘要: Methods and devices for making particles at small volumes.
摘要翻译: 用于制造小体积颗粒的方法和装置。
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公开(公告)号:US20230256436A1
公开(公告)日:2023-08-17
申请号:US18296954
申请日:2023-04-06
发明人: Pieter R. Cullis , Igor V. Jigaltsev , Robert James Taylor , Timothy Leaver , Andre Wild , Nathan Maurice Belliveau
IPC分类号: B01L3/00 , A61K9/107 , A61K9/127 , B01F23/41 , B01F25/431 , B01F25/433 , B01F33/30 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/00 , A61J3/00
CPC分类号: B01L3/50273 , A61K9/1075 , A61K9/1271 , A61K9/1277 , B01F23/41 , B01F25/431 , B01F25/4331 , B01F33/30 , A61K9/127 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/0002 , A61J3/00 , B01L3/502715 , Y10T428/2982 , B01F25/431971 , B01L2200/0605 , B01L2200/0647 , B01L2300/06 , B01L2300/0848 , B01L2300/0867 , B01L2300/18
摘要: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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公开(公告)号:US20200269201A1
公开(公告)日:2020-08-27
申请号:US15931901
申请日:2020-05-14
发明人: Andre Wild , Timothy Leaver , Robert James Taylor
摘要: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
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公开(公告)号:US20240335803A1
公开(公告)日:2024-10-10
申请号:US18434638
申请日:2024-02-06
发明人: Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
IPC分类号: B01F25/431 , A61K9/16 , B01F25/432 , B01F25/433 , B01F33/30 , B01F33/81 , B01F101/22 , B01J19/00 , G01N15/00 , G01N35/00
CPC分类号: B01F25/43161 , A61K9/1682 , B01F25/4323 , B01F25/4331 , B01F33/30 , B01F33/813 , B01J19/0093 , B01F25/43172 , B01F25/431971 , B01F2101/22 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00855 , B01J2219/00858 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00898 , B01J2219/00986 , G01N2015/0038 , G01N2035/00158
摘要: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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公开(公告)号:US20210113974A1
公开(公告)日:2021-04-22
申请号:US17127777
申请日:2020-12-18
发明人: Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
摘要: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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