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公开(公告)号：US10159652B2
公开(公告)日：2018-12-25
申请号：US15029993
申请日：2014-10-16
发明人： Colin Walsh , Andre Wild , Robert James Taylor , Timothy Leaver , Kevin Ou , Euan Ramsay , Aysha Ansari
摘要： Methods and devices for making particles at small volumes.
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公开(公告)号：US20180111830A1
公开(公告)日：2018-04-26
申请号：US15796646
申请日：2017-10-27
发明人： Andre Wild , Timothy Leaver , Colin Walsh , Gesine Heuck , Anitha Thomas , Aysha Ansari , Kevin Ou , Robert James Taylor , Euan Ramsay
CPC分类号： B82Y40/00 , B01F5/061 , B01F5/0644 , B01F5/0647 , B01F13/0059 , B01F13/0064 , B01F2005/0636 , B01L9/527 , B01L2200/025 , B01L2300/0816 , B81B1/00
摘要： The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
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公开(公告)号：US20160235688A1
公开(公告)日：2016-08-18
申请号：US15029993
申请日：2014-10-16
发明人： Colin Walsh , Andre Wild , Robert James Taylor , Timothy Leaver , Kevin Ou , Euan Ramsay , Aysha Ansari
IPC分类号： A61K9/51 , B01F13/00 , A61K31/7105 , B01F3/08
CPC分类号： A61K9/5192 , A61K9/5123 , A61K31/7105 , B01F3/08 , B01F3/0807 , B01F3/0811 , B01F3/0861 , B01F5/02 , B01F13/0062 , B01F13/1022 , B01F2215/0032 , B01J2/06
摘要： Methods and devices for making particles at small volumes.
摘要翻译： 用于制造小体积颗粒的方法和装置。
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公开(公告)号：US20190307689A1
公开(公告)日：2019-10-10
申请号：US16449176
申请日：2019-06-21
发明人： Euan Ramsay , R. James Taylor , Colin Walsh , Nathan M. Belliveau , Pieter R. Cullis , Timothy Leaver , Andre Wild
IPC分类号： A61K9/127 , A61K31/7088 , A61K47/44 , A61K47/32 , A61K31/7105 , A61K31/713 , A61K9/00 , C12N15/88 , A61K31/575 , A61K9/51 , A61K31/711
摘要： Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and, small molecule drugs, to cells.
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公开(公告)号：US20160022580A1
公开(公告)日：2016-01-28
申请号：US14775539
申请日：2014-03-14
IPC分类号： A61K9/127 , A61K31/7088 , A61K47/32 , A61K47/44 , A61K31/575
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1277 , A61K9/5123 , A61K9/5192 , A61K31/575 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/32 , A61K47/44 , C12N15/88
摘要： Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and. small molecule drugs, to cells.
摘要翻译： 转染试剂组合物，由转染试剂组合物制备的脂质纳米颗粒，包含转染试剂组合物的试剂盒，以及由转染试剂组合物制备和使用脂质纳米颗粒的方法。 当分散在水性介质中时，脂质容易形成脂质体，如单层囊泡和多层囊泡。 脂质体已被成功地用于包封和递送广泛的化学物质，包括核酸，蛋白质和。 小分子药物，细胞。
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公开(公告)号：US20240335803A1
公开(公告)日：2024-10-10
申请号：US18434638
申请日：2024-02-06
发明人： Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
IPC分类号： B01F25/431 , A61K9/16 , B01F25/432 , B01F25/433 , B01F33/30 , B01F33/81 , B01F101/22 , B01J19/00 , G01N15/00 , G01N35/00
CPC分类号： B01F25/43161 , A61K9/1682 , B01F25/4323 , B01F25/4331 , B01F33/30 , B01F33/813 , B01J19/0093 , B01F25/43172 , B01F25/431971 , B01F2101/22 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00855 , B01J2219/00858 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00898 , B01J2219/00986 , G01N2015/0038 , G01N2035/00158
摘要： The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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公开(公告)号：US20210113974A1
公开(公告)日：2021-04-22
申请号：US17127777
申请日：2020-12-18
发明人： Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
摘要： The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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公开(公告)号：US11938454B2
公开(公告)日：2024-03-26
申请号：US17127777
申请日：2020-12-18
发明人： Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
IPC分类号： B01F25/431 , A61K9/16 , B01F25/432 , B01F25/433 , B01F33/30 , B01F33/81 , B01F101/22 , B01J19/00 , G01N15/00 , G01N35/00
CPC分类号： B01F25/43161 , A61K9/1682 , B01F25/4323 , B01F25/4331 , B01F33/30 , B01F33/813 , B01J19/0093 , B01F25/43172 , B01F25/431971 , B01F2101/22 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00855 , B01J2219/00858 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00898 , B01J2219/00986 , G01N2015/0038 , G01N2035/00158
摘要： The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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公开(公告)号：US20210023514A1
公开(公告)日：2021-01-28
申请号：US17065432
申请日：2020-10-07
发明人： Euan Ramsay , Robert James Taylor , Timothy Leaver , Andre Wild , Kevin Ou , Colin Walsh
摘要： Disclosed herein are continuous flow systems having bifurcated fluidic flow mixers. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). DVBMs utilize Dean vortexing and bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing.
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公开(公告)号：US10597291B2
公开(公告)日：2020-03-24
申请号：US15796646
申请日：2017-10-27
发明人： Andre Wild , Timothy Leaver , Colin Walsh , Gesine Heuck , Anitha Thomas , Aysha Ansari , Kevin Ou , Robert James Taylor , Euan Ramsay
摘要： The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
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