公开(公告)号：US20200049713A1

公开(公告)日：2020-02-13

申请号：US16498581

申请日：2018-04-02

Applicant: Creatv MicroTech, Inc.

Inventor： Daniel ADAMS ,  Cha-Mei TANG

IPC: G01N33/574 ,  G01N33/50

Abstract: The characterization of nucleic acids obtained from cancer-associated cells circulating in the blood of a subject, and the use of such characterizations in cancer screening, diagnostics, treatment, and recurrence, are disclosed.

公开(公告)号：US20190242871A1

公开(公告)日：2019-08-08

申请号：US16369730

申请日：2019-03-29

Applicant: Creatv MicroTech, Inc.

Inventor： Daniel ADAMS ,  Cha-Mei TANG

IPC: G01N33/49 ,  G01N33/574 ,  G01N33/487

CPC classification number: G01N33/491 ,  G01N33/48735 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434

Abstract: A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of solid tumors, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.

公开(公告)号：US20190128892A1

公开(公告)日：2019-05-02

申请号：US16092998

申请日：2017-04-14

Applicant: Creatv MicroTech, Inc.

Inventor： Daniel ADAMS ,  Cha-Mei TANG

IPC: G01N33/574 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: Methods of using detection of PD-L1 expression by circulating cancer cells in the screening, monitoring, treatment and diagnosis of cancer in subjects are disclosed. The methods are based on assaying one or more of circulating tumor cells (CTCs), epithelial to mesenchymal transition CTCs (EMTCTCs), cancer associated macrophage-like cells (CAMLs), and cancer associated vascular endothelial cells (CAVEs) isolated from a subject having cancer for PD-L1 expression.

公开(公告)号：US20180156801A1

公开(公告)日：2018-06-07

申请号：US15576472

申请日：2016-05-26

Applicant: CREATV MICROTECH INC.

Inventor： Daniel ADAMS ,  Cha-Mei TANG

IPC: G01N33/574 ,  G01N33/50

Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

公开(公告)号：US20160021872A1

公开(公告)日：2016-01-28

申请号：US14776194

申请日：2014-03-13

Applicant: CREATV MICROTECH, INC.

Inventor： Peixuan ZHU ,  Daniel ADAMS ,  Cha-Mei TANG

IPC: A01N1/02 ,  G01N33/493 ,  G01N33/574

CPC classification number: A01N1/021 ,  A01N1/0215 ,  G01N33/493 ,  G01N33/574

Abstract: A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents.

Abstract translation: 公开了用于尿液的防腐剂，其在尿液中增加细胞（例如肿瘤细胞）的稳定性，持续数周。 防腐剂包括聚乙二醇（PEG），乙醇，多聚甲醛（PFA）和乙二胺四乙酸（EDTA），以及任选的pH稳定试剂。