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    Tissue preservation
    1.
    发明授权
    Tissue preservation 有权

    公开(公告)号：US11730164B2

    公开(公告)日：2023-08-22

    申请号：US17745800

    申请日：2022-05-16

    申请人： PHANTOMS BIOLOGICS RESEARCH LLC

    发明人： Clorinda V Contreras Villasmil

    IPC分类号： G01N1/30 ,  A01N1/02

    CPC分类号： A01N1/0215 ,  G01N1/30 ,  G01N2001/307

    摘要： A process for making and using a tissue preservation gel. The gel is comprised of water, reticulated acrylic acid, water soluble short-chain paraben, isopropyl alcohol and either triethanolamine or propylene glycol. To use the gel, a tissue to be preserved is first bathed in hypertonic sodium chloride, then soaked in a wash in multiple increasing concentrations of isopropyl alcohol and then preserved indefinitely in the tissue preservation gel.

    Hand-held device with reagents and method for detection and diagnostics
    5.
    发明授权
    Hand-held device with reagents and method for detection and diagnostics 有权

    公开(公告)号：US09061085B1

    公开(公告)日：2015-06-23

    申请号：US14184212

    申请日：2014-02-19

    申请人： U.S. Army Edgewood Chemical and Biological Command

    发明人： Jose Luis Sagripanti

    IPC分类号： A61L9/00 ,  A01N1/00 ,  B08B3/00 ,  A61L2/16

    CPC分类号： A61L2/16 ,  A01N1/0215 ,  A61L2/00 ,  A61L2/186 ,  A61L2/208 ,  B08B3/04 ,  C12H1/00 ,  C12H1/08 ,  C12N1/005 ,  G01N1/38

    摘要： A hand-held device and method of processing a biological threat agent sample such that any infectious organism is rendered harmless while preserving it for subsequent testing, the method comprising placing a sample comprising a biological threat agent in a reservoir; adding a first reagent comprising peracetic acid in sufficient concentration to reach a predetermined minimal concentration after mixing with the sample in the reservoir; inactivating the sample upon interaction of the sample with the first reagent for a predetermined period of time at a predetermined temperature; removing the inactivated sample from the reservoir; and providing the inactivated sample for subsequent diagnostic testing, wherein the subsequent diagnostic testing is unaffected by inactivation of the sample. In another embodiment, the first reagent comprises a cupric salt, which is mixed with ascorbic acid and hydrogen peroxide to generate cupric ascorbate.

    PROCESS FOR THE PREPARATION OF DISINFECTED HUMAN CELL SUSPENSIONS
    6.
    发明申请
    PROCESS FOR THE PREPARATION OF DISINFECTED HUMAN CELL SUSPENSIONS 有权
    制备消毒人体细胞悬浮液的方法

    公开(公告)号：US20150072428A1

    公开(公告)日：2015-03-12

    申请号：US14539158

    申请日：2014-11-12

    申请人： Cytonet GmbH & Co. KG

    发明人： Krasimira ALEKSANDROVA ,  Marc BARTHOLD ,  Lubomir ARSENIEV ,  Carsten GRIESEL ,  Christoph PRIESNER

    IPC分类号： A01N1/02

    CPC分类号： C12N5/067 ,  A01N1/0215 ,  C12N2501/70 ,  C12N2509/00

    摘要： In a process for preparing disinfected preparations from mammalian tissues, mammalian tissue is perfused at one step with an enzyme-free liquid antibiotic composition that includes at least one antibiotic and is contained in at least one perfusion buffer. In a step occurring after such one step, enzymatic antibiotic-free treatment of the tissue is carried out to obtain a single-cell suspension. In another step disinfected preparations are obtained.

    摘要翻译： 在从哺乳动物组织制备已消毒的制剂的方法中，哺乳动物组织用包含至少一种抗生素的无酶液体抗生素组合物在一步灌注，并且包含在至少一个灌注缓冲液中。 在这样一个步骤之后发生的步骤中，进行酶组织的无抗菌素处理以获得单细胞悬浮液。 在另一步骤中，获得消毒的制剂。

    IMMUNOCOMPATIBLE AMNIOTIC MEMBRANE PRODUCTS
    7.
    发明申请
    IMMUNOCOMPATIBLE AMNIOTIC MEMBRANE PRODUCTS 审中-公开
    免疫调节膜产品

    公开(公告)号：US20150010610A1

    公开(公告)日：2015-01-08

    申请号：US14272345

    申请日：2014-05-07

    申请人： OSIRIS THERAPEUTICS, INC.

    发明人： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

    IPC分类号： A61K35/50 ,  A61L27/36 ,  A61L27/54

    CPC分类号： A61K35/50 ,  A01N1/0215 ,  A01N1/0221 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/39 ,  A61K38/57 ,  A61K2035/122 ,  A61L27/3604 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/64 ,  C12N5/0605 ,  C12N2501/115

    摘要： Provided herein is a placental membrane product comprising an immunocompatible amniotic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing and tissue repair/regeneration as they are capable of promoting angiogenesis, reducing inflammation, inhibiting proteases and free radical oxidation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, and/or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

    摘要翻译： 本文提供了包含免疫兼容的羊膜的胎盘膜产品。 这样的胎盘膜产品可以在冷冻保存后含有治疗因子和解冻后的活细胞。 胎盘膜产品可用于伤口愈合和组织修复/再生，因为它们能够促进血管生成，减少炎症，抑制蛋白酶和自由基氧化，减少瘢痕形成以及促进愈合的其它方法。 本技术涉及用于保护受伤或损坏的组织或作为防止粘连的覆盖物，排除细菌，抑制细菌活性和/或促进组织愈合或生长的产品。 该领域还涉及这种膜衍生产品的制造方法和使用方法。

    SOLID MEDIUM FOR THE STORAGE OF BIOLOGICAL MATERIAL
    9.
    发明申请
    SOLID MEDIUM FOR THE STORAGE OF BIOLOGICAL MATERIAL 有权
    用于存储生物材料的固体介质

    公开(公告)号：US20140212880A1

    公开(公告)日：2014-07-31

    申请号：US13798483

    申请日：2013-03-13

    申请人： GE HEALTHCARE UK LIMITED

    发明人： MARTIN D. JAMES ,  JEFFREY K. HORTON ,  PETER J. TATNELL

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6806 ,  A01N1/0215 ,  C12N9/22 ,  C12N9/96 ,  C12Q2527/125 ,  C12Y301/00

    摘要： This invention relates to flat solid media for the storage of samples of biological materials and methods of analysing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids. The invention finds particular utility in the dry, room temperature storage of biological materials.

    摘要翻译： 本发明涉及用于储存生物材料样品的扁平固体培养基和分析存储在样品中之后的生物分子的方法。 特别地，本发明涉及存在于生物材料（例如蛋白质，酶和核酸）中的生物分子的储存和进一步分析。 本发明特别适用于生物材料的干燥，室温储存。

    Intracavity ultrasound probe disinfectant system
    10.
    发明授权
    Intracavity ultrasound probe disinfectant system 有权
    腔内超声探头消毒系统

    公开(公告)号：US08753580B2

    公开(公告)日：2014-06-17

    申请号：US13187171

    申请日：2011-07-20

    申请人： Philip Coles

    发明人： Philip Coles

    IPC分类号： A61L2/00 ,  B08B3/00 ,  A01N1/02 ,  A61L12/00 ,  A61K8/22 ,  A61K33/00 ,  B05C3/00

    CPC分类号： A61L2/186 ,  A01N1/0215 ,  A61B8/12 ,  A61B8/4209 ,  A61B8/4422 ,  A61K8/22 ,  A61K33/00 ,  A61L2/00 ,  A61L2/18 ,  A61L12/00 ,  A61L2202/14 ,  B05C3/00 ,  B08B3/00

    摘要： A disinfectant system for intracavity ultrasound probes in disclosed generally including a housing, a disinfectant chamber positioned in the housing and receiving at least one ultrasound probe, a container for containing a disinfectant solution fluidly coupled to the disinfectant chamber, at least one pump for supplying the disinfection solution from the container to the disinfection chamber and from the disinfection chamber to the container, and a controller for automated operation of the disinfectant system, wherein the disinfectant solution is a multi-use disinfectant solution. A method for disinfecting intracavity ultrasound probes is also disclosed generally including placing at least one ultrasound probe into a disinfectant chamber, supplying a disinfectant solution from a container to the disinfectant chamber via a pump, and returning the solution to the container via the pump, wherein the steps of supplying and returning the disinfectant solution are controlled by a controller.

    摘要翻译： 一种用于腔内超声波探头的消毒剂系统，通常包括壳体，位于壳体中并接收至少一个超声波探头的消毒室，用于容纳流体耦合到消毒室的消毒剂溶液的容器，至少一个泵， 从容器到消毒室以及从消毒室到容器的消毒溶液，以及用于消毒剂系统的自动操作的控制器，其中消毒剂溶液是多用途消毒剂溶液。 通常还公开了一种消毒腔内超声探头的方法，包括将至少一个超声波探针放置在消毒室中，通过泵将消毒剂溶液从容器提供到消毒室，并通过泵将溶液返回到容器中，其中 提供和返回消毒剂溶液的步骤由控制器控制。