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    NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY
    11.
    发明申请
    NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY 有权
    低粘度的新型蛋白质纤维素

    公开(公告)号：US20150374831A1

    公开(公告)日：2015-12-31

    申请号：US14766997

    申请日：2014-02-28

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Meinolf Brackhagen ,  Steven J. Guillaudeu ,  Nicholas S. Grasman ,  Oliver Petermann ,  Robert L. Schmitt ,  Matthias Sprehe

    IPC: A61K47/38 ,  C08B13/00

    CPC classification number: A61K47/38 ,  A61K9/2866 ,  A61K9/4891 ,  C08B13/00

    Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.

    Abstract translation: 酯化纤维素醚，其包含（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子，或（ iii）脂族一价酰基和式-C（O）-R-COOA基团的组合，其粘度高达2.33mPa·s，以2.0重量％的酯化纤维素醚溶液测量为0.43 20℃下的重量％NaOH水溶液，其粘度高达13mPao·s，以20wt％的酯化纤维素醚在丙酮中的10wt％溶液测量，可用于制备包含药物的固体分散体 。

    PROCESS OF PREPARING AN ESTERIFIED CELLULOSE ETHER IN THE PRESENCE OF AN ALKALI METAL CARBOXYLATE AND AN ALIPHATIC CARBOXYLIC ACID
    12.
    发明申请
    PROCESS OF PREPARING AN ESTERIFIED CELLULOSE ETHER IN THE PRESENCE OF AN ALKALI METAL CARBOXYLATE AND AN ALIPHATIC CARBOXYLIC ACID 审中-公开
    在碱性金属羧酸酯和二羧酸存在下制备已确认的纤维素醚的方法

    公开(公告)号：US20150218291A1

    公开(公告)日：2015-08-06

    申请号：US14420911

    申请日：2013-08-15

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Oliver Petermann ,  Matthias Sprehe ,  Warren K. Miller

    IPC: C08B13/00

    Abstract: In a process for preparing an esterified cellulose ether a cellulose ether is esterified with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an alkali metal carboxylate and an aliphatic carboxylic acid, wherein the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is not more than [1.20/1] and the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is from [3.55/1] to [9.0/1].

    Abstract translation: 在制备酯化纤维素醚的方法中，将纤维素醚与（i）脂族单羧酸酐或（ii）二羧酸酐或（iii）脂肪族单羧酸酐和二羧酸酐的组合在 碱金属羧酸盐和脂族羧酸的存在，其中[碱金属羧酸盐/纤维素醚的脱水葡萄糖单元]的摩尔比不超过[1.20 / 1]，摩尔比[纤维素醚的脂肪族羧酸/脱水葡萄糖单元 ]从[3.55 / 1]到[9.0 / 1]。

    PROCESS FOR FRACTIONATING AN ESTERIFIED CELLULOSE ETHER
    14.
    发明申请
    PROCESS FOR FRACTIONATING AN ESTERIFIED CELLULOSE ETHER 有权

    公开(公告)号：US20220056157A1

    公开(公告)日：2022-02-24

    申请号：US17394458

    申请日：2021-08-05

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Oliver Petermann ,  Matthias Knarr ,  Meinolf Brackhagen ,  Matthias Sprehe

    IPC: C08B11/20 ,  C08B13/00 ,  A61K9/14 ,  C08L1/26

    Abstract: A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of a) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid, b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, and c) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.

    ESTERIFIED CELLULOSE ETHERS OF LOW ACETONE-INSOLUBLE CONTENT
    18.
    发明申请
    ESTERIFIED CELLULOSE ETHERS OF LOW ACETONE-INSOLUBLE CONTENT 审中-公开

    公开(公告)号：US20170240654A1

    公开(公告)日：2017-08-24

    申请号：US15503600

    申请日：2015-08-18

    Applicant: Dow Global Technologies LLC

    Inventor： Oliver Petermann ,  Matthias Knarr ,  Matthias Sprehe

    IPC: C08B13/00 ,  C09D101/32 ,  A61K9/48

    CPC classification number: C08B13/00 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/4816 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

    Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

    NOVEL HYDROXYALKYL METHYL CELLULOSE ACETATE SUCCINATES
    19.
    发明申请
    NOVEL HYDROXYALKYL METHYL CELLULOSE ACETATE SUCCINATES 审中-公开
    新型羟基乙基甲基纤维素乙酸酯

    公开(公告)号：US20150218198A1

    公开(公告)日：2015-08-06

    申请号：US14421072

    申请日：2013-08-15

    Applicant: Dow Global Technologies LLC

    Inventor： Oliver Petermann ,  Matthias Sprehe ,  Steven J. Guillaudeu

    IPC: C07H3/06 ,  A61K9/48 ,  A61K47/38

    CPC classification number: C07H3/06 ,  A61K9/1652 ,  A61K9/4891 ,  A61K47/38 ,  C08B11/20 ,  C08B13/00

    Abstract: Novel hydroxyalkyl methyl cellulose acetate succinates which a) have from 4.0 to less than 10.0 weight percent of succinoyl groups, b) have a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, and c) exhibit a turbidity of up to 41 NTU as a 1.5 weight percent solution in acetone; and novel hydroxyalkyl methyl cellulose acetate succinates which a) have from 10.0 to 20.0 weight percent of succinoyl groups, b) have a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, and c) exhibit a turbidity of up to 37 NTU as a 1.5 weight percent solution in acetone are useful for preparing solid dispersion of active ingredients in these hydroxyalkyl methyl cellulose acetate succinates.

    Abstract translation: 新型羟烷基甲基纤维素乙酸酯琥珀酸酯，其a）具有4.0至小于10.0重量％的琥珀酰基，b）重均分子量Mw为80,000道尔顿至350,000道尔顿，和c）表现出高达41NTU的浊度 作为1.5重量％丙酮溶液; 和新的羟烷基甲基纤维素乙酸酯琥珀酸酯，其a）具有10.0至20.0重量％的琥珀酰基，b）具有80,000道尔顿至35万道尔顿的重均分子量Mw，和c）显示高达37NTU的浊度为 丙酮中的1.5重量％溶液可用于制备活性成分在这些羟烷基甲基纤维素乙酸酯琥珀酸酯中的固体分散体。

    PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER IN THE PRESENCE OF AN ALIPHATIC CARBOXYLIC ACID
    20.
    发明申请
    PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER IN THE PRESENCE OF AN ALIPHATIC CARBOXYLIC ACID 审中-公开
    制备纤维素醚的方法在存在一种二羧酸的情况下

    公开(公告)号：US20150218197A1

    公开(公告)日：2015-08-06

    申请号：US14420921

    申请日：2013-08-15

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Oliver Petermann ,  Matthias Sprehe ,  Robert L. Schmitt ,  Andrew C. Arthur ,  Warren K. Miller ,  David K. Lyon

    IPC: C07H3/06

    CPC classification number: C07H3/06 ,  C08B11/20 ,  C08B13/00

    Abstract: Two or more esters of a cellulose ether, each having the same ether and ester substituents but different weight average molecular weights are prepared in a process which comprises the steps of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an aliphatic carboxylic acid as a reaction diluent in two or more separate reactions, wherein in each reaction a different molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is used to produce esters of the cellulose ether of different weight average molecular weights.

    Abstract translation: 在包括以下步骤的方法中制备两种或更多种纤维素醚的酯，它们各自具有相同的醚和酯取代基但不同的重均分子量，该方法包括以下步骤：（i）脂肪族单羧酸酐或（ii） 二羧酸酐或（iii）脂肪族单羧酸酐和二羧酸酐在脂肪族羧酸作为反应稀释剂的存在下在两个或更多个分开的反应中的组合，其中在每个反应中不同的摩尔比[脂族 纤维素醚的羧酸/脱水葡萄糖单元]用于生产不同重均分子量的纤维素醚的酯。

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