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公开(公告)号：US09890220B2
公开(公告)日：2018-02-13
申请号：US14766609
申请日：2014-02-28
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Meinolf Brackhagen , Matthias Sprehe
CPC classification number: C08B13/00 , A61K9/146 , A61K9/2866 , A61K9/4816 , C08B11/20 , C08L1/32
Abstract: Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.
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2.发明申请公开(公告)号：US20160347866A1
公开(公告)日：2016-12-01
申请号：US15113921
申请日：2015-01-27
Applicant: DOW GLOBAL TECHNOLOGIES LLC
Inventor： Oliver Petermann , Matthias Sprehe , Meinolf Brackhagen
CPC classification number: C08B13/00 , A61K9/10 , A61K9/146 , A61K9/2866 , A61K9/4816 , A61K47/38 , C08B11/20
Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula ——C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.0, and iv) an Mz/Mn of not more than 18.5, when the weight average molecular weight Mw, the number average molecular weight Mn and the z-average molecular weight Mz are measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH2—PO4 and 0.1 M NaNO3. are useful as enteric polymers for pharmaceutical dosage forms.
Abstract translation: 酯化纤维素醚，其具有i）酯基脂族一价酰基或脂族一价酰基的组合和式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是 氢或阳离子，ii）重均分子量Mw为80,000道尔顿至220,000道尔顿，iii）多分散性Mw / Mn为1.3至4.0，以及iv）Mz / Mn不大于18.5，当重量 平均分子量Mw，数均分子量Mn和z平均分子量Mz通过SEC-MALLS使用由40体积份乙腈和60体积份含有50mM NaH2-PO4和0.1M NaNO3。 可用作药物剂型的肠溶性聚合物。
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3.发明申请公开(公告)号：US20150202301A1
公开(公告)日：2015-07-23
申请号：US14421064
申请日：2013-08-15
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Sprehe , Meinolf Brackhagen , Steven J. Guillaudeu
Abstract: Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.
Abstract translation: 酯化纤维素醚，其具有i）脂族一价酰基和式-C（O）-R-COOA基团的组合，其中R是二价脂族或芳族烃基，A是氢或阳离子，ii）重量 平均分子量Mw为80,000道尔顿至350,000道尔顿，iii）多分散性Mw / Mn为1.3至4.1，以及iv）粘度高达4.0mPa·s，以2.0wt％的酯化纤维素醚溶液 在20℃下0.43重量％的NaOH水溶液可用作药物剂型的肠溶性聚合物。
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公开(公告)号：US20150065547A1
公开(公告)日：2015-03-05
申请号：US14390041
申请日：2012-10-24
Applicant: Dow Global Technologies LLC
Inventor： Robert L. Schmitt , Robert L. Sammler , Meinolf Brackhagen , Oliver Petermann , Roland Adden , Nicholas S. Grasman , Steven J. Guillaudeu
IPC: A61K47/38 , A61K47/10 , A61K9/48 , A61K31/4166 , A61K9/14 , C08B13/00 , A61K31/343
CPC classification number: A61K47/38 , A61K9/08 , A61K9/145 , A61K9/146 , A61K9/4816 , A61K9/4858 , A61K9/4866 , A61K31/343 , A61K31/4166 , A61K47/10 , C08B11/193 , C08B13/00
Abstract: An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The esterified cellulose ether is useful as an excipient for poorly water-soluble drugs.
Abstract translation: 酯化的纤维素醚包括（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子或（iii） 脂族一价酰基和式-C（O）-R-COOA基团的组合，其中纤维素醚具有通过1-4键连接并具有甲基，羟基烷基和任选的烷基的脱水葡萄糖单元， 甲基作为取代基使得酯化纤维素醚具有0.05至1.00的MS（羟烷基），脱水葡萄糖单元的羟基被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.36以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中仅th 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。 酯化纤维素醚可用作水溶性差的药物的赋形剂。
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公开(公告)号：US20150031873A1
公开(公告)日：2015-01-29
申请号：US14384220
申请日：2013-03-12
Applicant: Dow Global Technologies LLC
Inventor： Matthias Sprehe , Oliver Petermann , Robert Bruce Appell
IPC: C08B13/00
Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic mono-carboxylic acid anhydride and a di- or tri-carboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.
Abstract translation: 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二 - 或三羧酸酐的反应或与脂肪族单羧酸酐和二 - 或三羧酸酐在（c）脂族羧酸存在下反应。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。
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Patent Agency Ranking
公开(公告)号：US10759873B2
公开(公告)日：2020-09-01
申请号：US15113921
申请日：2015-01-27
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Sprehe , Meinolf Brackhagen
Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.0, and iv) an Mz/Mn of not more than 18.5, when the weight average molecular weight Mw, the number average molecular weight Mn and the z-average molecular weight Mz are measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH2—PO4 and 0.1 M NaNO3. are useful as enteric polymers for pharmaceutical dosage forms.
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公开(公告)号：US20200010572A1
公开(公告)日：2020-01-09
申请号：US16072650
申请日：2017-06-20
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann
Abstract: An esterified cellulose ether is provided wherein the ester groups are phthalyl groups, the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, and the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C.
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公开(公告)号：US10513599B2
公开(公告)日：2019-12-24
申请号：US16072691
申请日：2017-08-22
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann
Abstract: A cellulose ether acetate phthalate is provided, wherein the degree of substitution of phthalyl groups is from 0.02 to 0.25, the degree of neutralization of phthalyl groups is not more than 0.5, the degree of substitution of acetyl groups is from 0.02 to 0.40, and the total degree of substitution of phthalyl and acetyl groups is not more than 0.50. The cellulose ether acetate phthalate has a solubility in water of at least 2.0 weight percent at 2° C.
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公开(公告)号：US10377835B2
公开(公告)日：2019-08-13
申请号：US15550094
申请日：2016-03-08
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Knarr
Abstract: 1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mw of up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules.
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公开(公告)号：US20190177514A1
公开(公告)日：2019-06-13
申请号：US16072691
申请日：2017-08-22
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann
IPC: C08L1/32
Abstract: A cellulose ether acetate phthalate is provided, wherein the degree of substitution of phthalyl groups is from 0.02 to 0.25, the degree of neutralization of phthalyl groups is not more than 0.5, the degree of substitution of acetyl groups is from 0.02 to 0.40, and the total degree of substitution of phthalyl and acetyl groups is not more than 0.50. The cellulose ether acetate phthalate has a solubility in water of at least 2.0 weight percent at 2° C.
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