公开(公告)号：US20170319706A1

公开(公告)日：2017-11-09

申请号：US15526027

申请日：2015-11-05

Applicant: Dow Global Technologies LLC

Inventor： Jaime L. Curtis-Fisk ,  Robert B. Appell ,  Peter M. Margl ,  Susan L. Jordan ,  True L. Rogers

IPC: A61K47/61 ,  A61K31/14 ,  A61K9/08 ,  C08B15/06 ,  A61K9/00

CPC classification number: A61K47/61 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/14 ,  A61K47/38 ,  C08B15/06

Abstract: Provided is a method of delivering a drug to a mucosal surface in a living body, said method comprising applying a solution to said mucosal surface, wherein said solution comprises a cationic polymer dissolved in water, wherein said cationic polymer comprises a cationic functional group covalently attached to a polysaccharide polymer backbone selected from the group consisting of amylodextrin polymers, methylcellulose polymers, and hydroxypropyl methylcellulose polymers.

公开(公告)号：US20160120990A1

公开(公告)日：2016-05-05

申请号：US14888119

申请日：2014-07-16

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Jaime L. Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Robert B. Appell ,  Matthias Knarr ,  Roland Adden

IPC: A61K47/38 ,  A61K31/167 ,  A61K9/00 ,  A61K47/02

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a hydroxyalkyl methylcellulose and a liquid diluent, wherein the hydroxyalkyl methylcellulose has a DS of from 1.6 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, and at least 55 weight percent of the liquid diluent is water. When the composition comprises additionally a physiologically active agent, the composition may be used for transmucosal administration of the physiologically active agent to an individual.

Abstract translation: 设计用于粘膜的组合物包括张力调节剂，羟烷基甲基纤维素和液体稀释剂，其中羟烷基甲基纤维素的DS为1.6至2.7，MS为0.40至1.30，其中DS为 甲氧基和MS的取代是羟基烷氧基的摩尔取代，至少55重量％的液体稀释剂是水。 当该组合物另外包含生理活性剂时，该组合物可以用于生理活性剂向个体的经粘膜施用。

公开(公告)号：US20150057356A1

公开(公告)日：2015-02-26

申请号：US14389838

申请日：2013-04-08

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Nicholas S. Grasman ,  True L. Rogers ,  Oliver Petermann ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K47/38 ,  B29C47/00 ,  A61K9/20 ,  A61K31/192

CPC classification number: A61K47/38 ,  A61K9/1652 ,  A61K9/2095 ,  A61K31/192 ,  B29C47/004 ,  B29C47/0066 ,  B29C2793/009 ,  B29K2001/08 ,  B29K2105/0035 ,  C08B11/193 ,  C08L1/28 ,  C08L1/284

Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Abstract translation: 一种熔融挤出的聚合物组合物，其包含a）至少一种纤维素醚，b）一种或多种活性成分和c）一种或多种任选的添加剂，其中所述至少一种纤维素醚具有0.05至0.55的MS（羟烷基）和羟基 脱水葡萄糖单元的基团被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.32以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2位和3位的两个羟基， 脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位上的两个羟基仅被甲基取代。