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    Method for controlled preparation of low molecular weight cellulose ether
    1.
    发明授权
    Method for controlled preparation of low molecular weight cellulose ether 有权

    公开(公告)号：US11407842B2

    公开(公告)日：2022-08-09

    申请号：US16608892

    申请日：2018-06-29

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Robert B. Appell ,  Joseph L Weir

    IPC: C08B11/08

    Abstract: A process includes: (a) providing an initial cellulose ether powder containing 0.5 to 10 weight-percent water based on total cellulose ether powder weight; (b) heating the initial cellulose ether powder to a temperature in a range of 30 to 130 degrees Celsius; (c) before, during and/or after heating in step (b), adding solid base to the cellulose ether powder and mixing with the initial cellulose ether powder to form a cellulose ether/base mixture; (d) adding volatile acid to the cellulose ether/base mixture and mixing; and (e) allowing the volatile acid to hydrolyze the initial cellulose ether to form a final cellulose ether having a lower viscosity than the initial cellulose ether.

    Process of preparing an ester of a cellulose ether
    2.
    发明授权
    Process of preparing an ester of a cellulose ether 有权
    制备纤维素醚的酯的方法

    公开(公告)号：US09453081B2

    公开(公告)日：2016-09-27

    申请号：US14384220

    申请日：2013-03-12

    Applicant: Dow Global Technologies LLC

    Inventor： Matthias Sprehe ,  Oliver Petermann ,  Robert B. Appell

    IPC: C08B3/00 ,  C08B3/12 ,  C08B3/28 ,  C08B13/00 ,  C08B11/20

    CPC classification number: C08B13/00 ,  C08B11/20

    Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

    Abstract translation: 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二羧酸或三羧酸酐的反应或与脂族一元羧酸酐和二羧酸或三羧酸的组合 （c）脂族羧酸存在下的酸酐。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。

    NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY LOW VISCOSITY
    5.
    发明申请
    NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY LOW VISCOSITY 有权
    新颖的纤维素非常低的粘度

    公开(公告)号：US20150376299A1

    公开(公告)日：2015-12-31

    申请号：US14766786

    申请日：2014-02-28

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Oliver Petermann ,  Robert B. Appell ,  Meinolf Brackhagen

    IPC: C08B13/00 ,  A61K47/38

    CPC classification number: C08B13/00 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/4816 ,  A61K47/38 ,  C08B11/20

    Abstract: An esterified cellulose ether which comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, and which has a) a viscosity of from 1.2 to 1.8 mPaos, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., or b) a viscosity of up to 5 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., or c) a combination of the viscosities of a) and b), is useful for preparing solid dispersions comprising drugs.

    Abstract translation: 酯化纤维素醚，其包含（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子，或 （iii）脂族一价酰基和式-C（O）-R-COOA基团的组合，其具有a）粘度为1.2至1.8mPaos，以2.0wt％的酯化纤维素溶液 醚，在20℃下在0.43wt％NaOH水溶液中，或b）粘度高达5mPa·s，以20wt％的酯化纤维素醚在丙酮中的10wt％溶液测量，或c） a）和b）的粘度的组合可用于制备包含药物的固体分散体。

    Size reduction of ethylcellulose polymer particles
    6.
    发明授权
    Size reduction of ethylcellulose polymer particles 有权

    公开(公告)号：US11312789B2

    公开(公告)日：2022-04-26

    申请号：US15533381

    申请日：2015-12-10

    Applicant: Dow Global Technologies LLC

    Inventor： Jorg Theuerkauf ,  Robert B. Appell ,  Peter E. Pierini ,  Christopher J. Tucker

    IPC: C08B11/20 ,  C08J3/05 ,  C08J3/12 ,  C08B11/08 ,  F28D1/04

    Abstract: Provided is a process for reducing the size of ethylcellulose polymer particles comprising (a) providing a slurry comprising (i) water (ii) said ethylcellulose particles, wherein said ethylcellulose polymer particles have D50 of 100 μm or less; (iii) surfactant comprising 1.2% or more anionic surfactants by weight based on the solid weight of said slurry, with the proviso that if the amount of anionic surfactant is 2.5% or less by weight based on the solid weight of said slurry, then said surfactant further comprises 5% or more stabilizers by weight based on the solid weight of said slurry, wherein said stabilizer is selected from the group consisting of water-soluble polymers, water-soluble fatty alcohols, and mixtures thereof. (b) grinding said slurry in an agitated media mill having a collection of media particles having a median particle size of 550 μm or smaller. Also provided is a dispersion made by such a process.

    SIZE REDUCTION OF ETHYLCELLULOSE POLYMER PARTICLES
    10.
    发明申请
    SIZE REDUCTION OF ETHYLCELLULOSE POLYMER PARTICLES 审中-公开

    公开(公告)号：US20170369596A1

    公开(公告)日：2017-12-28

    申请号：US15533381

    申请日：2015-12-10

    Applicant: Dow Global Technologies LLC

    Inventor： Jorg Theuerkauf ,  Robert B. Appell ,  Peter E. Pierini ,  Christopher J. Tucker

    IPC: C08B11/20 ,  C08B11/08 ,  C08J3/12 ,  C08J3/05 ,  F28D1/04

    CPC classification number: C08B11/20 ,  C08B11/08 ,  C08J3/05 ,  C08J3/12 ,  C08J2301/28 ,  F28D1/04

    Abstract: Provided is a process for reducing the size of ethylcellulose polymer particles comprising (a) providing a slurry comprising (i) water (ii) said ethylcellulose particles, wherein said ethylcellulose polymer particles have D50 of 100 μm or less; (iii) surfactant comprising 1.2% or more anionic surfactants by weight based on the solid weight of said slurry, with the proviso that if the amount of anionic surfactant is 2.5% or less by weight based on the solid weight of said slurry, then said surfactant further comprises 5% or more stabilizers by weight based on the solid weight of said slurry, wherein said stabilizer is selected from the group consisting of water-soluble polymers, water-soluble fatty alcohols, and mixtures thereof. (b) grinding said slurry in an agitated media mill having a collection of media particles having a median particle size of 550 μm or smaller. Also provided is a dispersion made by such a process.

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