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Patent Agency Ranking
公开(公告)号：US11174489B2
公开(公告)日：2021-11-16
申请号：US17176040
申请日：2021-02-15
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas Pronk , Antonius Jeroen Adriaan Van Maris , Victor Gabriel Guadalupe Medina
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US10738317B2
公开(公告)日：2020-08-11
申请号：US15970641
申请日：2018-05-03
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas Pronk , Antonius Jeroen Adriaan Van Maris , Victor Gabriel Guadalupe Medina
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US10689670B2
公开(公告)日：2020-06-23
申请号：US16309422
申请日：2017-06-13
Applicant: DSM IP ASSETS B.V.
Inventor： Ioannis Papapetridis , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paulus Petrus De Waal , Niels Lauret , Maarten Dirk Verhoeven , Jozef Petrus Johannes Schmitz
Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein the phosphoribulokinase is under control of a promoter (the “PRK promoter”) that enables higher expression under anaerobic conditions than under aerobic conditions.
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公开(公告)号：US10913928B2
公开(公告)日：2021-02-09
申请号：US16471367
申请日：2017-12-18
Applicant: DSM IP Assets B.V.
Abstract: This invention relates to a recombinant cell, preferably a recombinant yeast cell comprising: a) a gene coding for an enzyme having glycerol-3-phosphate dehydrogenase activity, wherein said enzyme has a cofactor dependency for at least NADP+ and/or for NADPH; b) a gene encoding an enzyme having at least NAD+ dependent acetylating acetaldehyde dehydrogenase activity (EC 1.2.1.10); and c) a mutation or disruption in at least one gene selected from the group of GPD1 and GPD2. Said cell is suitable for ethanol production, has a reduced glycerol production at high ethanol yield.
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公开(公告)号：US09359613B2
公开(公告)日：2016-06-07
申请号：US14189989
申请日：2014-02-25
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas Pronk , Antonius Jeroen Adriaan Van Maris , Victor Gabriel Guadalupe Medina
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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