-
11.
公开(公告)号:US20140108033A1
公开(公告)日:2014-04-17
申请号:US14029405
申请日:2013-09-17
申请人: Kunter Seref Akbay , Christopher Donald Johnson , Angela Neff Patterson , Andrew Phelps Day , Ilkin Onur Dulgeroglu , David S. Toledano , Bex George Thomas , Dan Yang , Peter Leigh Katlic , Marcia Peterson
发明人: Kunter Seref Akbay , Christopher Donald Johnson , Angela Neff Patterson , Andrew Phelps Day , Ilkin Onur Dulgeroglu , David S. Toledano , Bex George Thomas , Dan Yang , Peter Leigh Katlic , Marcia Peterson
CPC分类号: G06Q50/22 , G06Q10/06315 , G16H40/20
摘要: Snapshot data may be received indicative of a current state of resources that deliver healthcare to a plurality of patients associated with a healthcare enterprise. The received snapshot data may be automatically used to initialize a healthcare enterprise simulation model. The healthcare enterprise simulation model may then be executed to automatically generate a predicted future state of the resources at a predetermined point in time. Some embodiments may automatically suggest mitigation strategies based on simulated scenarios reflecting potential bottlenecks and appropriate actions that may be taken by the enterprise. The system may continuously and automatically monitor forecast accuracy to detect potential anomalies.
摘要翻译: 可以接收快照数据,指示将医疗保健提供给与医疗保健企业相关联的多个患者的资源的当前状态。 收到的快照数据可以自动用于初始化医疗保健企业仿真模型。 然后可以执行医疗保健企业模拟模型,以在预定时间点自动生成资源的预测未来状态。 一些实施例可以基于模拟的场景来自动建议缓解策略,反映出企业可能采取的潜在瓶颈和适当的行动。 系统可以连续自动监测预测精度,以检测潜在的异常情况。
-
公开(公告)号:US08299067B2
公开(公告)日:2012-10-30
申请号:US12410473
申请日:2009-03-25
申请人: Dan Yang , Chengyong Li , Shiwu Chen
发明人: Dan Yang , Chengyong Li , Shiwu Chen
IPC分类号: A61K31/535 , A61K31/497 , A61K31/445 , C07D413/00 , C07D405/00 , C07D401/00 , C07D205/00 , C07D303/00
CPC分类号: C07D303/16 , C07D339/08
摘要: Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.
摘要翻译: 本文提供5-脱甲氧基烟曲霉及其衍生物。 本文还提供制备5-去甲氧基烟曲霉及其衍生物的方法。 本文还提供了5-去甲氧基烟曲霉素及其衍生物的生物活性及其用于治疗疾病的方法。
-
公开(公告)号:US08232626B2
公开(公告)日:2012-07-31
申请号:US12814938
申请日:2010-06-14
申请人: Yat Kit Tsui , Dan Yang , Xunqing Shi
发明人: Yat Kit Tsui , Dan Yang , Xunqing Shi
CPC分类号: H01L21/76898 , H01L23/481 , H01L2224/16145 , H01L2924/1461 , H01L2924/00
摘要: An electronic or micromechanical device having first (11) and second (12) surfaces and a via extending through the device from the first surface to the second surface. The via comprises integrally formed first (84, 86), second (82) and third (88) portions. The first portion (84, 86) extends from the first surface (11) to the second surface (12). The second portion (82) extends over a part of the first surface (11) of the device. The third portion (88) extends over a part of the second surface (12) of the device. Preferably the first portion comprises first and second parts, the second part extending through an active region of the device and having a narrower width than the first part. A method of forming and filling the via is also disclosed.
摘要翻译: 具有第一表面(11)和第二表面(12)的电子或微机械装置以及从第一表面延伸穿过该装置到第二表面的通孔。 通孔包括一体形成的第一(84,86),第二(82)和第三(88)部分。 第一部分(84,86)从第一表面(11)延伸到第二表面(12)。 第二部分(82)在装置的第一表面(11)的一部分上延伸。 第三部分(88)在装置的第二表面(12)的一部分上延伸。 优选地,第一部分包括第一部分和第二部分,第二部分延伸穿过装置的有源区域并且具有比第一部分更窄的宽度。 还公开了形成和填充通孔的方法。
-
公开(公告)号:US20110304026A1
公开(公告)日:2011-12-15
申请号:US12814938
申请日:2010-06-14
申请人: Yat Kit Tsui , Dan Yang , Xunqing Shi
发明人: Yat Kit Tsui , Dan Yang , Xunqing Shi
IPC分类号: H01L23/48 , H05K1/11 , H01L21/02 , H01L21/768
CPC分类号: H01L21/76898 , H01L23/481 , H01L2224/16145 , H01L2924/1461 , H01L2924/00
摘要: An electronic or micromechanical device having first (11) and second (12) surfaces and a via extending through the device from the first surface to the second surface. The via comprises integrally formed first (84, 86), second (82) and third (88) portions. The first portion (84, 86) extends from the first surface (11) to the second surface (12). The second portion (82) extends over a part of the first surface (11) of the device. The third portion (88) extends over a part of the second surface (12) of the device. Preferably the first portion comprises first and second parts, the second part extending through an active region of the device and having a narrower width than the first part. A method of forming and filling the via is also disclosed.
摘要翻译: 具有第一表面(11)和第二表面(12)的电子或微机械装置以及从第一表面延伸穿过该装置到第二表面的通孔。 通孔包括一体形成的第一(84,86),第二(82)和第三(88)部分。 第一部分(84,86)从第一表面(11)延伸到第二表面(12)。 第二部分(82)在装置的第一表面(11)的一部分上延伸。 第三部分(88)在装置的第二表面(12)的一部分上延伸。 优选地,第一部分包括第一部分和第二部分,第二部分延伸穿过设备的有源区域并且具有比第一部分更窄的宽度。 还公开了形成和填充通孔的方法。
-
公开(公告)号:US08055130B2
公开(公告)日:2011-11-08
申请号:US12003950
申请日:2008-01-03
申请人: Dan Yang
发明人: Dan Yang
CPC分类号: H04B10/2971 , H04B10/40
摘要: Systems and devices for use as optical transceivers and amplifiers in optical networks. An optical transceiver/amplifier has two optical signal circulators, each of which receives one incoming signal and transmits one outgoing optical signal. Each circulator combines its incoming and outgoing signals on to a bidirectional optical connection internal to the transceiver amplifier. Between the two circulators are a pump laser, an optical coupler to couple the pump laser's power into the bidirectional connection, and an amplifying medium for amplifying the bidirectional signals internal to the transceiver amplifier. The amplifying medium may be an Erbium doped fiber which would amplify any optical signal passing through it. In one embodiment, the transceiver amplifier is in a self-contained package that is pluggable into existing equipment using pre-existing ports and interfaces.
摘要翻译: 用作光网络中的光收发器和放大器的系统和设备。 光收发器/放大器具有两个光信号循环器,每个光信号循环器接收一个输入信号并发送一个输出光信号。 每个循环器将其输入和输出信号组合到收发器放大器内部的双向光学连接。 两个循环器之间是泵浦激光器,将泵浦激光器的功率耦合到双向连接中的光耦合器,以及用于放大收发器放大器内部的双向信号的放大媒体。 放大介质可以是掺铒光纤,其将放大通过它的任何光信号。 在一个实施例中,收发器放大器是可以使用预先存在的端口和接口插入现有设备的独立包装。
-
公开(公告)号:US20110212975A1
公开(公告)日:2011-09-01
申请号:US12850806
申请日:2010-08-05
申请人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
发明人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
IPC分类号: A61K31/496 , C07D413/06 , A61P31/16
CPC分类号: C07D413/06 , A61K31/496
摘要: Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
摘要翻译: 本文描述了显示抗病毒活性,特别是针对流感病毒的化合物及其制备和使用方法。 在一个实施方案中,化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。 可以将化合物与一种或多种药学上可接受的赋形剂配制以形成适于肠内或肠胃外给药的组合物。 该化合物优选用于治疗或预防甲型流感感染,如H1N1,H2N2,H3N2,H5N1,H7N7,H1N2,H9N2,H7N2,H7N3和H10N7。
-
公开(公告)号:US20090163595A1
公开(公告)日:2009-06-25
申请号:US12337642
申请日:2008-12-18
申请人: Dan Yang , Xiang Li , Bing Shen , Xiao-Qiang Yao
发明人: Dan Yang , Xiang Li , Bing Shen , Xiao-Qiang Yao
IPC分类号: A61K31/166 , C12N5/06
CPC分类号: A61K31/166
摘要: Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and/or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.
摘要翻译: 本文提供了使用自组装化合物调节细胞膜的膜电位的方法。 本文还提供了使用本文公开的自组装化合物来调节细胞膜中天然的依赖于电压的离子通道的方法。 本文还提供了通过使用本文公开的自组装化合物治疗,预防和/或控制与异常膜电位反应相关的疾病的方法。
-
公开(公告)号:US11518740B2
公开(公告)日:2022-12-06
申请号:US17239575
申请日:2021-04-24
申请人: Qianqian Zhao , Jie Zhang , Liang Xin , Jingyi Li , Ruina Bian , Yuqing Zhao , Dan Yang , Han Li , Bin Tian , Yongbo Wang , Chengyuan Liang
发明人: Qianqian Zhao , Jie Zhang , Liang Xin , Jingyi Li , Ruina Bian , Yuqing Zhao , Dan Yang , Han Li , Bin Tian , Yongbo Wang , Chengyuan Liang
IPC分类号: C07C323/52 , C07C319/20
摘要: A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
-
19.
公开(公告)号:US11427526B2
公开(公告)日:2022-08-30
申请号:US17026224
申请日:2020-09-19
申请人: Jia Wan , Jie Zhang , Chunchun Kong , Yi Jin , Min Fan , Han Li , Qiaoqiao Zhao , Dan Yang
发明人: Jia Wan , Jie Zhang , Chunchun Kong , Yi Jin , Min Fan , Han Li , Qiaoqiao Zhao , Dan Yang
摘要: A method of preparing a compound of formula (I): is disclosed. The compound of formula (I) can be used as an antioxidant agent. The compound can also be used as an antibacterial agent to inhibit Staphylococcus aureus MRSA 18-222 and Pseudomonas aeruginosa MDR-PA 18-1774.
-
20.
公开(公告)号:US11168049B1
公开(公告)日:2021-11-09
申请号:US17128100
申请日:2020-12-19
申请人: Yonghong Tang , Minghui Chang , Huafeng Qi , Bin Tian , Juan Li , Liang Xin , Jingyi Li , Dan Yang , Han Li , Yanjun Li , Liang Qi , Wenbo Yao , Chengyuan Liang
发明人: Yonghong Tang , Minghui Chang , Huafeng Qi , Bin Tian , Juan Li , Liang Xin , Jingyi Li , Dan Yang , Han Li , Yanjun Li , Liang Qi , Wenbo Yao , Chengyuan Liang
IPC分类号: C07C69/732 , C07C67/08
摘要: A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
-
-
-
-
-
-
-
-
-