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11.发明授权Azetidine derivatives, their preparation and pharmaceutical compositions containing them 有权氮杂环丁烷衍生物，其制备方法和含有它们的药物组合物公开(公告)号：US06479479B2
公开(公告)日：2002-11-12
申请号：US09798072
申请日：2001-03-02
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： C07D20504
CPC分类号： C07D401/06 , C04B35/632 , C07D205/04 , C07D205/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Compounds of formula: in which R represents a CR1R2, C═C(R5)SO2R6 or C═C(R7)SO2alk radical, their preparation and the pharmaceutical compositions containing them.
摘要翻译： 其中R代表CR1R2，C = C（R5）SO2R6或C = C（R7）SO2基团，其制备方法和含有它们的药物组合物。
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公开(公告)号：US07741316B2
公开(公告)日：2010-06-22
申请号：US10988337
申请日：2004-11-12
申请人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： A01N43/00 , A61K31/397 , A61K31/00 , C07D217/00 , C07D215/12 , C07D421/00 , C07D401/00 , C07D403/00 , C07D205/00 , C07D263/60 , C07D277/60 , C07D295/00 , C07D277/62 , C07D277/20 , C07D413/00 , C07D263/52
CPC分类号： C07D401/06 , C04B35/632 , C07D205/04 , C07D205/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D409/06 , C07D409/12 , C07D409/14
摘要： A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula: in which R, R3 and R4 are as defined in the specification.
摘要翻译： 一种治疗或预防阿尔茨海默病，帕金森病和/或精神分裂症的方法，该方法包括向需要这种治疗的患者施用下式的化合物：其中R，R 3和R 4如说明书中所定义。
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13.发明授权Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation 失效含有3-氨基氮杂环丁烷衍生物的药物组合物及其制备方法公开(公告)号：US07132414B2
公开(公告)日：2006-11-07
申请号：US10771764
申请日：2004-02-04
申请人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： A61K31/498 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D205/04 , C07D403/12 , C07D409/12
摘要： The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—R6, Y is CO or SO2, R4 represents a radical -alk-SO2—R11, -alk-SO2—CH═CH—R11 or Het substituted with —SO2—R11 or a phenyl radical substituted with —SO2—R11 or -alk-SO2—R11, R5 represents a hydrogen atom or an alkyl radical, R6 represents a phenylalkyl, Het or Ar radical, to the novel derivatives of formula (I) and to their preparation, as well s to their use in treating various disorders of the nervous system.
摘要翻译： 本发明涉及含有下列化合物作为活性成分的药物组合物：其中R 1代表基团-NHCOR 4或-N（R 1） 5）-YR 6，Y是CO或SO 2，R 4表示基团-OR 3， 2 -OR 11，-alk-SO 2 -CH-CH-R 11或被-SO
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公开(公告)号：US20050130953A1
公开(公告)日：2005-06-16
申请号：US10988337
申请日：2004-11-12
申请人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael Myers
发明人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael Myers
IPC分类号： A61P3/04 , A61P25/00 , C07D205/04 , C07D205/06 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D409/06 , C07D409/12 , C07D409/14 , A61K31/4709 , A61K31/397 , A61K31/4439
CPC分类号： C07D401/06 , C04B35/632 , C07D205/04 , C07D205/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D409/06 , C07D409/12 , C07D409/14
摘要： A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula: in which R, R3 and R4 are as defined in the specification.
摘要翻译： 一种治疗或预防阿尔茨海默病，帕金森病和/或精神分裂症的方法，该方法包括向需要这种治疗的患者施用下式的化合物：其中R 3，R 3和R 3 > 4 如说明书中所定义。
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15.发明授权Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation 有权含有氮杂环丁烷衍生物的药物组合物，新的氮杂环丁烷衍生物及其制备方法公开(公告)号：US06355631B1
公开(公告)日：2002-03-12
申请号：US09798452
申请日：2001-03-02
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： C07D20504
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to pharmaceutical compositions containing, as an active ingredient, at least one compound of formula: in which R1 represents a radical —N(R4)R5, —N(R4)—CO—R5, —N(R4)—SO2R6 or one of its pharmaceutically acceptable salts, to the novel derivatives of formula (I), to their pharmaceutically acceptable salts and to their preparation.
摘要翻译： 本发明涉及含有至少一种下式化合物作为活性成分的药物组合物：其中R 1表示-N（R 4）R 5，-N（R 4）-CO-R 5，-N（R 4） - SO2R6或其药学上可接受的盐之一，与式（I）的新衍生物，其药学上可接受的盐及其制备方法。
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16.发明授权Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation 失效含有3-氨基氮杂环丁烷衍生物的药物组合物及其制备方法公开(公告)号：US06734176B2
公开(公告)日：2004-05-11
申请号：US10320894
申请日：2002-12-17
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： A61K31498
CPC分类号： C07D401/12 , C07D205/04 , C07D403/12 , C07D409/12
摘要： The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—R6, Y is CO or SO2, R4 represents a radical -alk-SO2—R11, -alk-SO2—CH═CH—R11 or Het substituted with —SO2—R11 or a phenyl radical substituted with —SO2—R11 or -alk-SO2—R11, R5 represents a hydrogen atom or an alkyl radical, R6 represents a phenylalkyl, Het or Ar radical, to the novel derivatives of formula (I) and to their preparation, as well s to their use in treating various disorders of the nervous system.
摘要翻译： 本发明涉及含有下列化合物作为活性成分的药物组合物：其中R1代表基团-NHCOR4或-N（R5）-Y-R6，Y是CO或SO2，R4代表自由基 - SO2-R11，-alk-SO2-CH = CH-R11或被-SO2-R11取代的苯基或被-SO2-R11或-alk-SO2-R11取代的苯基，R5表示氢原子或烷基， R6代表式（I）的新衍生物的苯基烷基，Het或Ar基团及其制备，以及它们在治疗各种神经系统疾病中的用途。
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17.发明授权Streptogramin derivatives, their preparation and compositions containing them 有权链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US06569854B1
公开(公告)日：2003-05-27
申请号：US09609717
申请日：2000-06-30
申请人： Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
发明人： Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
IPC分类号： A61K3805
CPC分类号： A61K38/12 , A61K38/15 , C07K5/06182 , A61K38/08 , A61K2300/00
摘要： Group A streptogramin derivatives of general formula (I) in which: R1 represents a halogen atom or an azido or thiocyanato radical, R2 represents a hydrogen atom or a methyl or ethyl radical, R3 represents a hydrogen atom, or the residue of an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclylaliphatic ester which may be substituted, and the bond - - - represents a single bond (stereochemistry 27R) or a double bond, as well as its salts when they exist.
摘要翻译： A组通式（I）的链霉素衍生物，其中：R1表示卤素原子或叠氮基或硫氰酸根基，R2表示氢原子或甲基或乙基，R3表示氢原子，或脂族， 脂环族，芳香族，芳脂族，杂环或杂环脂族酯，并且键 - - 表示单键（立体化学27R）或双键，以及它们存在时的盐。
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18.发明授权Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation 失效含有3-氨基氮杂环丁烷衍生物的药物组合物及其制备方法公开(公告)号：US06566356B2
公开(公告)日：2003-05-20
申请号：US09798589
申请日：2001-03-02
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Bruno Filoche , Serge Grisoni , Augustin Hittinger , Michael R. Myers
IPC分类号： C07D40302
CPC分类号： C07D401/12 , C07D205/04 , C07D403/12 , C07D409/12
摘要： The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—R6, Y is CO or SO2, R4 represents a radical -alk-SO2—R11, -alk-SO2—CH═CH—R11 or Het substituted with —SO2—R11 or a phenyl radical substituted with —SO2—R11 or -alk-SO2—R11, R5 represents a hydrogen atom or an alkyl radical, R6 represents a phenylalkyl, Het or Ar radical, to the novel derivatives of formula (I) and to their preparation.
摘要翻译： 本发明涉及含有下列化合物作为活性成分的药物组合物：其中R1代表基团-NHCOR4或-N（R5）-Y-R6，Y是CO或SO2，R4代表自由基 - SO2-R11，-alk-SO2-CH = CH-R11或被-SO2-R11取代的苯基或被-SO2-R11或-alk-SO2-R11取代的苯基，R5表示氢原子或烷基， R6代表式（I）的新型衍生物及其制备方法的苯基烷基，Het或Ar基团。
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19.发明授权Streptogramin derivatives, their preparation and compositions containing them 有权链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US07166594B2
公开(公告)日：2007-01-23
申请号：US10310773
申请日：2002-12-06
申请人： Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
发明人： Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
IPC分类号： A61K31/535 , A61K31/655 , A61K31/42
CPC分类号： A61K38/12 , A61K38/15 , C07K5/06182 , A61K38/08 , A61K2300/00
摘要： Group A streptogramin derivatives of general formula (I) in which: R1 represents a halogen atom or an azido or thiocyanato radical, R2 represents a hydrogen atom or a methyl or ethyl radical, R3 represents a hydrogen atom, or the residue of an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclylaliphatic ester which may be substituted, and the bond --- represents a single bond (stereochemistry 27R) or a double bond, as well as its salts when they exist
摘要翻译： A组通式（I）的链霉素衍生物，其中：R 1表示卤素原子或叠氮基或硫氰酸根基团，R 2表示氢原子或甲基或 乙基，R 3表示氢原子，或可以被取代的脂族，脂环族，芳族，芳脂族，杂环或杂环脂族酯的残基，并且键 ---表示单键（立体化学27R）或双键，以及其存在时的盐
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公开(公告)号：US5739351A
公开(公告)日：1998-04-14
申请号：US849177
申请日：1997-05-30
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P43/00 , C07D209/44 , C07D401/06 , C07D409/06
CPC分类号： C07D401/06 , C07D209/44 , C07D409/06
摘要： New perhydroinsoindole having the general formula (I) wherein R.sub.1 is optionally substituted phenyl or is cyclohexadienyl, naphtyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R.sub.2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R.sub.3 is phenyl optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF.sub.3, and R.sub.4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N.sub.3 or --NHCN, and the radicals R which are similar or different represent H, alkyl or phenyl, in their isomer forms having the structure (Ia) or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P.
摘要翻译： PCT No.PCT / FR95 / 01577 Sec。 371日期1997年5月30日 102（e）日期1997年5月30日PCT提交1995年11月29日PCT公布。 公开号WO96 / 16939 （Ia）具有通式（I）的新的全氢异吲哚，其中R 1为任选取代的苯基或环己二烯基，萘基，茚基或单环或多环杂环基，饱和或不饱和的5 烷基氨基烷基，二烷基氨基烷基，烷氧基，烷硫基，酰氧基，羧基，烷氧基羰基，二烷基氨基羰基氧基羰基，苄氧羰基，氨基或酰氨基，R3是任选被取代的苯基， 2或由OH或F取代或被CF 3二取代的烷基，R 4是含有1或2个被卤素或CN，N 3或-NHCN取代的烷基，基团R相同或相同， 不同的是代表具有结构（Ia）或其混合物的异构体形式的H，烷基或苯基，当它们存在时可以是它们的盐和它们的制备。 本发明的新衍生物特别可用作物质P的拮抗剂。
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