公开(公告)号：US08383777B2

公开(公告)日：2013-02-26

申请号：US11842072

申请日：2007-08-20

申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/1709 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/57492

摘要： A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.

摘要翻译： 描述了一种新型前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中被开启。 24P4C12提供了前列腺癌和其他癌症的诊断和/或治疗靶点。

公开(公告)号：US08053551B2

公开(公告)日：2011-11-08

申请号：US10408009

申请日：2003-04-04

申请人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

IPC分类号： C07K5/10

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US07785811B2

公开(公告)日：2010-08-31

申请号：US11061341

申请日：2005-02-18

申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Aya Jakobovits

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Aya Jakobovits

IPC分类号： G01N33/574

CPC分类号： C07K14/47 ,  A61K39/00 ,  A61K48/00 ,  C07K2317/24 ,  C07K2319/02 ,  C12N2799/026 ,  C12N2799/027

摘要： Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.

摘要翻译： 描述了一种新型基因及其编码的分泌的肿瘤抗原，称为BPC-1，以及用于治疗表达BPC-1的各种癌症的诊断和治疗方法和组合物，特别包括前列腺癌和膀胱癌。 在人正常组织中，BPC-1仅在脑的某些组织中表达。 然而，BPC-1在前列腺癌细胞中以高水平表达，并且也在膀胱癌细胞中表达。 BPC-1的结构包括信号序列和CUB域。 分泌BPC-1蛋白。 初步实验证据表明，BPC-1直接参与肿瘤发生或维持表达BPC-1的癌细胞的转化表型。 BPC-1也似乎特异性结合前列腺癌细胞和其他细胞中表达的细胞蛋白。

公开(公告)号：US07485299B2

公开(公告)日：2009-02-03

申请号：US11546008

申请日：2006-10-10

申请人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

IPC分类号： A61K39/395

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US07319006B2

公开(公告)日：2008-01-15

申请号：US10856109

申请日：2004-05-28

申请人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

IPC分类号： C12Q1/68

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAP's are described and characterized herein. The human STEAP's exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（ Six 上皮 Prostate的抗原。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。