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1.发明申请公开(公告)号：US20180125978A1
公开(公告)日：2018-05-10
申请号：US15625764
申请日：2017-06-16
Applicant: Lipocine Inc.
Inventor： Mahesh V. Patel
IPC: A61K47/14 , A61K9/16 , A61K31/7048 , A61K31/568 , A61K31/5513 , A61K31/5383 , A61K31/496 , A61K31/4709 , A61K31/352 , B82Y5/00
CPC classification number: A61K47/14 , A61K9/1617 , A61K9/1676 , A61K9/4858 , A61K9/5015 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/352 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K31/5513 , A61K31/568 , A61K31/7048 , A61K47/10 , B82Y5/00 , Y02A50/463 , Y10S977/906 , Y10S977/927
Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation cost on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.
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公开(公告)号：US20170216206A1
公开(公告)日：2017-08-03
申请号：US15262863
申请日：2016-09-12
Applicant: CASE WESTERN RESERVE UNIVERSITY
CPC classification number: A61K9/127 , A61K9/0019 , A61K31/704 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K47/02 , A61K47/6941 , A61K49/0084 , A61K49/0093 , A61K49/0438 , A61K49/0466 , A61K49/14 , A61K49/1824 , Y10S977/773 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10T428/2982
Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.
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公开(公告)号：US09439966B2
公开(公告)日：2016-09-13
申请号：US14351420
申请日：2012-10-12
Applicant: CASE WESTERN RESERVE UNIVERSITY
CPC classification number: A61K9/127 , A61K9/0019 , A61K31/704 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K47/02 , A61K47/6941 , A61K49/0084 , A61K49/0093 , A61K49/0438 , A61K49/0466 , A61K49/14 , A61K49/1824 , Y10S977/773 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10T428/2982
Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.
Abstract translation: 用于诊断和治疗应用的多组分纳米链包括连接在一起形成纳米链的至少三种纳米颗粒。 纳米链的至少一个纳米颗粒具有由不对称设置的第一接头和第二接头定义的不对称表面化学。 通过连接设置在分离的纳米颗粒上的第一接头和/或第二接头连接纳米颗粒以形成纳米链。
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公开(公告)号：US09399075B2
公开(公告)日：2016-07-26
申请号：US13872539
申请日：2013-04-29
Applicant: General Electric Company
Inventor： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino , Bruce Allan Hay , Amit Mohan Kulkarni
CPC classification number: A61K49/101 , A61K49/0002 , A61K49/04 , A61K49/0428 , A61K49/0485 , A61K49/1818 , A61K49/1848 , B82Y5/00 , B82Y30/00 , C01G35/00 , Y10S977/773 , Y10S977/779 , Y10S977/927 , Y10S977/928 , Y10T428/2982
Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。
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5.发明申请Solid Carriers for Improved Delivery of Active Ingredients in Pharmaceutical Compositions 审中-公开用于改善药物组合物中活性成分递送的固体载体公开(公告)号：US20140357586A1
公开(公告)日：2014-12-04
申请号：US14460188
申请日：2014-08-14
Applicant: Lipocine Inc.
Inventor： Mahesh V. Patel
IPC: A61K31/7048 , A61K31/496 , A61K31/5383 , A61K31/4709 , A61K31/352 , A61K31/568 , A61K31/5513
CPC classification number: A61K47/14 , A61K9/1617 , A61K9/1676 , A61K9/4858 , A61K9/5015 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/352 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K31/5513 , A61K31/568 , A61K31/7048 , A61K47/10 , B82Y5/00 , Y02A50/463 , Y10S977/906 , Y10S977/927
Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.
Abstract translation: 本发明提供用于改善递送其中所含的各种药物活性成分或单独施用的固体药物组合物。 在一个实施方案中，固体药物组合物包括固体载体，固体载体包括底物和基材上的包封涂层。 包封涂层可以包括药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酯的不同组合。 在另一个实施方案中，固体药物组合物包括固体载体，固体载体由药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酸酯的不同组合形成。 本发明的组合物可用于改进递送亲水或疏水性药物活性成分，例如药物，营养剂，药妆和诊断剂。
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Patent Agency Ranking
公开(公告)号：US20130101511A1
公开(公告)日：2013-04-25
申请号：US13446274
申请日：2012-04-13
Applicant: Daniel Ansaldi , Kevin P. Francis , Rajendra Singh , Ning Zhang
Inventor： Daniel Ansaldi , Kevin P. Francis , Rajendra Singh , Ning Zhang
IPC: A61K49/00
CPC classification number: A61K49/0013 , A61K49/0067 , B82Y5/00 , G01N2800/7095 , Y10S977/773 , Y10S977/927
Abstract: Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided.
Abstract translation: 描述了用于检测活生物体（例如动物）中的酶活性的组合物和方法。
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公开(公告)号：US20130058873A1
公开(公告)日：2013-03-07
申请号：US13566260
申请日：2012-08-03
Applicant: Wilfred Jefferies , Mei Mei Tian , Timothy Vitalis
Inventor： Wilfred Jefferies , Mei Mei Tian , Timothy Vitalis
IPC: C07K14/79 , A61K38/40 , A61K49/00 , C07K19/00 , A61K49/04 , A61K49/14 , A61P35/00 , A61P35/04 , A61P25/28 , A61P25/16 , A61P25/00 , A61P29/00 , C12N9/96 , B82Y15/00 , B82Y5/00
CPC classification number: A61K47/48276 , A61K38/00 , A61K38/1793 , A61K38/40 , A61K39/39533 , A61K39/3955 , A61K39/44 , A61K47/6425 , C07K14/70575 , C07K14/79 , C07K16/18 , C07K2319/00 , C07K2319/55 , C07K2319/60 , C07K2319/70 , Y10S977/773 , Y10S977/92 , Y10S977/927
Abstract: The present invention is related to fragments of human melanotransferrin (p97). In particular, this invention relates to treatment of diseases through the introduction of the melanotransferrin fragment conjugated to a therapeutic or diagnostic agent to a subject.
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公开(公告)号：US08033977B2
公开(公告)日：2011-10-11
申请号：US12415618
申请日：2009-03-31
Applicant: James F. Hainfeld , Daniel N. Slatkin
Inventor： James F. Hainfeld , Daniel N. Slatkin
IPC: A61N5/00
CPC classification number: A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
Abstract translation: 本发明提供使用直径为0.5-400nm的金属纳米粒子的方法，以增强X射线或其它类型辐射在消融诸如肿瘤的靶组织的治疗方案中的剂量和效力。 金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。 金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。 增强的辐射方法也可用于离体消融不需要的组织或细胞。
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公开(公告)号：US20090186060A1
公开(公告)日：2009-07-23
申请号：US12415618
申请日：2009-03-31
Applicant: James F. Hainfeld , Daniel N. Slatkin
Inventor： James F. Hainfeld , Daniel N. Slatkin
CPC classification number: A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
Abstract translation: 本发明提供使用直径为0.5-400nm的金属纳米粒子的方法，以增强X射线或其它类型辐射在消融诸如肿瘤的靶组织的治疗方案中的剂量和效力。 金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。 金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。 增强的辐射方法也可用于离体消融不需要的组织或细胞。
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10.发明申请SOLID CARRIERS FOR IMPROVED DELIVERY OF ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS 审中-公开用于改善药物组合物中活性成分的固体载体公开(公告)号：US20090074859A1
公开(公告)日：2009-03-19
申请号：US12326711
申请日：2008-12-02
Applicant: Mahesh Patel
Inventor： Mahesh Patel
CPC classification number: A61K47/14 , A61K9/1617 , A61K9/1676 , A61K9/4858 , A61K9/5015 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/352 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K31/5513 , A61K31/568 , A61K31/7048 , A61K47/10 , B82Y5/00 , Y02A50/463 , Y10S977/906 , Y10S977/927
Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.
Abstract translation: 本发明提供用于改善递送其中所含的各种药物活性成分或单独施用的固体药物组合物。 在一个实施方案中，固体药物组合物包括固体载体，固体载体包括底物和基材上的包封涂层。 包封涂层可以包括药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酯的不同组合。 在另一个实施方案中，固体药物组合物包括固体载体，固体载体由药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酸酯的不同组合形成。 本发明的组合物可用于改进递送亲水或疏水性药物活性成分，例如药物，营养剂，药妆和诊断剂。
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