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公开(公告)号：US20100316994A1
公开(公告)日：2010-12-16
申请号：US12343170
申请日：2008-12-23
申请人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译： 本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。
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12.发明申请Nucleic acid and corresponding protein entitled 121P2A3 useful in treatment and detection of cancer 审中-公开核酸和相应的蛋白质121P2A3可用于治疗和检测癌症公开(公告)号：US20080233598A1
公开(公告)日：2008-09-25
申请号：US11704092
申请日：2007-02-06
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Daniel E. H. Afar , Doulas Saffran , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Daniel E. H. Afar , Doulas Saffran , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： G01N33/567 , C07H21/04 , C12N15/00 , C12N5/02
CPC分类号： C07K14/47
摘要： A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为121P2A3）及其编码的蛋白质及其变体，其中121P2A3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P2A3提供诊断，预后， 癌症的预防和/或治疗靶标。 121P2A3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P2A3反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07199220B2
公开(公告)日：2007-04-03
申请号：US10283903
申请日：2002-10-29
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
IPC分类号： C07K14/47 , C07K14/705
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
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14.发明授权公开(公告)号：US06838258B2
公开(公告)日：2005-01-04
申请号：US10017066
申请日：2001-12-14
申请人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Douglas C. Saffran
发明人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Douglas C. Saffran
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/3069 , C07K2317/34
摘要： A novel gene (designated PHOR-1) that is highly overdressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.
摘要翻译： 描述了在前列腺和其他癌症及其编码的蛋白质中高度过度摄取的新基因（称为PHOR-1）。 PHOR-1是与涉及嗅觉的受体具有同源性的G蛋白偶联受体。 正常人组织中的PHOR-1仅限于前列腺，并且该基因在前列腺癌以及肾，子宫，宫颈，胃和直肠的癌症中高度过度表达。 因此，PHOR-1为前列腺癌提供了诊断和/或治疗靶点。
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公开(公告)号：US07897740B2
公开(公告)日：2011-03-01
申请号：US12393936
申请日：2009-02-26
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： C07H21/02
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary, and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌的肿瘤抗原，称为36P6D5，以及可用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾，前列腺，乳腺，结肠，卵巢， 和胰腺。
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16.发明授权公开(公告)号：US07534417B2
公开(公告)日：2009-05-19
申请号：US09793451
申请日：2001-02-26
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
IPC分类号： A61K51/10 , A61K39/395 , C07H21/04 , C07K14/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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公开(公告)号：US20090074797A1
公开(公告)日：2009-03-19
申请号：US12170208
申请日：2008-07-09
申请人： Daniel E. H. Afar , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
发明人： Daniel E. H. Afar , Arthur B. Raitano , Rene S. Hubert , Steve Chappell Mitchell , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , C12N2799/026 , Y02A50/465 , Y02A50/473
摘要： The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.
摘要翻译： 本发明涉及一种与几种异质核核糖核蛋白（hnRNPs）具有同源性的命名为20P2H8的新型蛋白质。 本文提供了全长约3600bp的20P2H8 cDNA（SEQ ID NO：1，编码517个氨基酸的开放阅读框（SEQ ID NO：2））。
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18.发明授权公开(公告)号：US07172898B2
公开(公告)日：2007-02-06
申请号：US10283722
申请日：2002-10-29
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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19.发明授权121P1F1: a tissue specific protein highly expressed in various cancers 失效121P1F1：在各种癌症中高度表达的组织特异性蛋白公开(公告)号：US06924358B2
公开(公告)日：2005-08-02
申请号：US09799250
申请日：2001-03-05
申请人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , Y02A50/465 , Y02A50/473
摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质。 121P1F1在正常成人组织中表现出组织特异性表达，但其在前列腺，膀胱，肾，脑，骨，子宫颈，子宫，卵巢，乳腺，胰腺，胃，结肠，直肠，白细胞，肝，肺等多种癌症中异常表达 癌症 因此，121P1F1提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的121P1F1基因或其片段，或其编码的蛋白质或其片段。
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20.发明授权公开(公告)号：US06790631B1
公开(公告)日：2004-09-14
申请号：US09680728
申请日：2000-10-05
申请人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Douglas C. Saffran
发明人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steve Chappell Mitchell , Douglas C. Saffran
IPC分类号： G01M3353
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/3069 , C07K2317/34
摘要： A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.
摘要翻译： 描述了在前列腺和其他癌症及其编码的蛋白质中高度过表达的新基因（称为PHOR-1）。 PHOR-1是与涉及嗅觉的受体具有同源性的G蛋白偶联受体。 正常人组织中的PHOR-1仅限于前列腺，并且该基因在前列腺癌以及肾，子宫，宫颈，胃和直肠的癌症中高度过度表达。 因此，PHOR-1为前列腺癌提供了诊断和/或治疗靶点。
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