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11.发明申请Nucleic acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer 失效核酸和相应的标题为158P3D2的蛋白质可用于治疗和检测癌症公开(公告)号：US20090286316A1
公开(公告)日：2009-11-19
申请号：US11483354
申请日：2006-07-06
申请人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
IPC分类号： C12N5/06
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为158P3D2）及其编码的蛋白质及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后， 癌症的预防和/或治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07507541B2
公开(公告)日：2009-03-24
申请号：US11805969
申请日：2007-05-24
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： G01N33/53
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和 胰腺。
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公开(公告)号：US06566078B1
公开(公告)日：2003-05-20
申请号：US09702114
申请日：2000-10-30
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： G01N3353
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译： 描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和 胰腺。
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14.发明授权Nucleic acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer 失效核酸和相应的标题为158P3D2的蛋白质可用于治疗和检测癌症公开(公告)号：US08039000B2
公开(公告)日：2011-10-18
申请号：US11483354
申请日：2006-07-06
申请人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为158P3D2）及其编码的蛋白质及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后， 癌症的预防和/或治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20110150910A1
公开(公告)日：2011-06-23
申请号：US12686939
申请日：2010-01-13
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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16.发明授权Method of inhibiting growth or survival of a cell by providing an anti-108P5H8 antibody 失效通过提供抗-108P5H8抗体来抑制细胞生长或存活的方法公开(公告)号：US07510840B1
公开(公告)日：2009-03-31
申请号：US10280711
申请日：2002-10-25
申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
发明人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
IPC分类号： G01N33/53 , G01N33/574 , C07K16/00 , A61K39/395
CPC分类号： C07K14/705 , A01K2217/05 , A61K2039/505 , A61K2039/53 , C07K16/18 , C07K2317/21 , Y10S530/809
摘要： A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为108P5H8）及其编码的蛋白及其变体，其中108P5H8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，108P5H8提供诊断，预后， 癌症的预防和/或治疗靶标。 108P5H8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07459539B2
公开(公告)日：2008-12-02
申请号：US10024652
申请日：2001-12-17
申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
发明人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
CPC分类号： C07K14/705 , A01K2217/05 , A61K2039/505 , A61K2039/53 , C07K16/18 , C07K2317/21 , Y10S530/809
摘要： A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为108P5H8）及其编码的蛋白及其变体，其中108P5H8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，108P5H8提供诊断，预后， 癌症的预防和/或治疗靶标。 108P5H8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US06835822B1
公开(公告)日：2004-12-28
申请号：US09698781
申请日：2000-10-27
申请人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： C07H2104
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译： 本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。
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19.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 121P1F1 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和相关蛋白121P1F1可用于治疗和检测癌症公开(公告)号：US20120076789A1
公开(公告)日：2012-03-29
申请号：US13243297
申请日：2011-09-23
申请人： Pia M. CHALLITA-EID , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Wangmao Ge , Aya Jakobovits
发明人： Pia M. CHALLITA-EID , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K39/00 , A61K2039/505 , C07K14/47
摘要： A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P1F1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P1F1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P1F1 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质及其变体，其中121P1F1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P1F1提供诊断，预后， 癌症的预防和/或治疗靶标。 121P1F1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P1F1反应的抗体或T细胞可用于主动或被动免疫。
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20.发明授权Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer 失效核酸和相应的蛋白质121P1F1可用于治疗和检测癌症公开(公告)号：US08039603B2
公开(公告)日：2011-10-18
申请号：US12473056
申请日：2009-05-27
申请人： Pia M. Challita-Eid , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Wangmao Ge , Aya Jakobovits
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/34 , G01N33/574 , Y02A50/466
摘要： A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P1F1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P1F1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P1F1 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质及其变体，其中121P1F1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P1F1提供诊断，预后， 癌症的预防和/或治疗靶标。 121P1F1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P1F1反应的抗体或T细胞可用于主动或被动免疫。
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