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11.发明申请公开(公告)号：US20080200466A1
公开(公告)日：2008-08-21
申请号：US11915168
申请日：2006-05-22
申请人： Jake Axford , Urs Baettig , Brian Cox , Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham
发明人： Jake Axford , Urs Baettig , Brian Cox , Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham
IPC分类号： A61K31/5375 , C07D207/16 , A61K31/40 , A61K31/4453 , A61K31/495 , C07D241/04 , C07D211/06 , C07D265/30
CPC分类号： C07D295/185
摘要： Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, R6, R7, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.
摘要翻译： 游离或药学上可接受的盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，m，n，w，X和Y具有如上所述的含义 在本说明书中，可用于治疗由CRTH2受体介导的病症，特别是炎性或阻塞性气道疾病。
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12.发明申请公开(公告)号：US20140309254A1
公开(公告)日：2014-10-16
申请号：US14316503
申请日：2014-06-26
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： C07D471/04 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书中所述， 制备它们的过程，以及它们作为药物的用途。
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公开(公告)号：US20100210610A1
公开(公告)日：2010-08-19
申请号：US12699723
申请日：2010-02-03
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： A61K31/56 , C07D471/04 , A61K31/437 , C07D413/12 , A61K31/5377 , A61P11/00 , A61P11/08 , A61P11/14 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：US08431703B2
公开(公告)日：2013-04-30
申请号：US12096448
申请日：2006-12-07
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free ors salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离盐形式的式（I）化合物，其中R 1，R 2，R 4，R 5，R 6，A，D，X，W，m和n如说明书中所述， 准备他们，并用作药物。
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公开(公告)号：US20080312229A1
公开(公告)日：2008-12-18
申请号：US12096453
申请日：2006-12-07
IPC分类号： A61K31/437 , A61P25/00 , A61P29/00 , A61P37/00 , A61P19/00 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 4，R 5，R 6，A，D，X，W，m和n如说明书中所述， 准备他们，并用作药物。
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公开(公告)号：US20080269335A1
公开(公告)日：2008-10-30
申请号：US11568464
申请日：2005-05-03
CPC分类号： C07C51/09 , C07C59/72 , C07C67/11 , C07C69/712 , C07C255/54 , C07C2601/14
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R , R , R , X, Y, Z, m, and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，X，Y，Z，m和n如 规格，制备方法及其作为药物的用途。
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公开(公告)号：US20080287416A1
公开(公告)日：2008-11-20
申请号：US12096448
申请日：2006-12-07
IPC分类号： C07D487/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61P29/00 , A61P11/00 , A61P37/08
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free ors salt form, whereinR1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离盐形式的式（I）化合物，其中R 1，R 2，R 4， R 5，R 6，A，D，X，W，m和n如说明书中所述，其制备方法及其作为药物的用途。
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公开(公告)号：US20080312322A1
公开(公告)日：2008-12-18
申请号：US11915091
申请日：2006-05-22
申请人： Urs Baettig , Brian Cox , Katharine Louise Turner , Simon James Watson , Diana Janus , Catherine Leblanc , David Andrew Sandham
发明人： Urs Baettig , Brian Cox , Katharine Louise Turner , Simon James Watson , Diana Janus , Catherine Leblanc , David Andrew Sandham
CPC分类号： C07C317/22 , C07C59/70 , C07C69/712 , C07C205/37 , C07C235/22 , C07C323/20 , C07C2601/02
摘要： A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.
摘要翻译： 式（I）化合物; 其中R 1，R 2，R 3，R 4，R 5，m，n，w，X，Y和Q具有如说明书中所示的含义，可用于治疗CRTh2受体介导的病症， 特别是炎性或阻塞性气道疾病。
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公开(公告)号：US20100087432A1
公开(公告)日：2010-04-08
申请号：US11720786
申请日：2005-12-12
IPC分类号： A61K31/5377 , C07D215/20 , C07D413/12 , C07D403/10 , A61K31/4709 , A61K31/497 , A61P37/06
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明提供式（I）化合物作为CRTh2拮抗剂。 游离或盐形式，其中R3，R4，R5，R6，Q，W和n如说明书中所述，其制备方法及其作为药物的用途。
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公开(公告)号：US20170066766A1
公开(公告)日：2017-03-09
申请号：US15357195
申请日：2016-11-21
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
摘要翻译： 制备所述化合物的方法及其治疗用途。 本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。
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