公开(公告)号：US08695722B2

公开(公告)日：2014-04-15

申请号：US10681253

申请日：2003-10-09

申请人： Kazumasa Fukazawa ,  Masayuki Mukaino ,  David Andrews

发明人： Kazumasa Fukazawa ,  Masayuki Mukaino ,  David Andrews

IPC分类号： E02F3/76

CPC分类号： E02F3/80 ,  B60K11/04 ,  B62D55/06 ,  E02F3/7609 ,  E02F9/0808 ,  E02F9/0858 ,  E02F9/0891

摘要： A bulldozer provides improved visibility in front and/or rear of the bulldozer. The bulldozer includes an engine arranged in the front of the bulldozer and a cooling module for cooling the engine arranged elsewhere in the bulldozer, such as behind driver's seat. In the bulldozer, the arrangement of the engine, the vehicle, and the cooling module provides improved visibility in front of the bulldozer so that the operator of the bulldozer can view the upper middle portion of the bulldozer blade.

摘要翻译： 推土机在推土机的前部和/或后部提供更好的可见性。 推土机包括布置在推土机前部的发动机和用于冷却设置在推土机其他地方（例如驾驶员座椅后面）的发动机的冷却模块。 在推土机中，发动机，车辆和冷却模块的布置提高了在推土机前面的可见性，使得推土机的操作者可以观察推土机叶片的上部中部。

公开(公告)号：US08022394B2

公开(公告)日：2011-09-20

申请号：US12338648

申请日：2008-12-18

申请人： Gemma Solomon ,  David Andrews ,  Mark Ratner

发明人： Gemma Solomon ,  David Andrews ,  Mark Ratner

IPC分类号： H01L31/00 ,  H01L29/06

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  G11C13/0014 ,  G11C13/02 ,  H01L51/0591

摘要： A molecular quantum interference device for use in molecular electronics. In one embodiment, the device includes a molecular quantum interference unit having a first terminal group and a second terminal group between which quantum interference affects electrical conduction, a molecular spacer having a first terminal group and a second terminal group and coupled to the molecular quantum interference unit through a chemical bonding between the first terminal group of the molecular spacer and the second terminal group of the molecular quantum interference unit, a first electrode electrically coupled to the molecular quantum interference unit and configured to supply charge carriers to or receive charge carriers from the molecular quantum interference unit, and a second electrode electrically coupled to the molecular spacer and configured to receive charge carriers from or supply charge carriers to the molecular spacer.

摘要翻译： 用于分子电子学的分子量子干涉装置。 在一个实施方案中，该装置包括分子量子干涉单元，其具有第一端基和第二端基，其间量子干涉影响电传导，分子间隔物具有第一端基和第二端基并与分子量子干涉 通过分子间隔物的第一末端基团和分子量子干涉单元的第二末端基团之间的化学键合单元，第一电极，电耦合到分子量子干涉单元，并且被配置为向电荷载体提供电荷载体， 分子量子干涉单元和电耦合到分子间隔物的第二电极，并且被配置为从电荷载体接收电荷载体或将电荷载体接收到分子间隔物。

公开(公告)号：US20100070737A1

公开(公告)日：2010-03-18

申请号：US12233320

申请日：2008-09-18

申请人： Colin Stirling ,  David I. Lawrie ,  David Andrews

发明人： Colin Stirling ,  David I. Lawrie ,  David Andrews

IPC分类号： G06F12/06

CPC分类号： G06F9/345 ,  G06F9/3455 ,  G06F9/3552 ,  G06F9/3875 ,  H03M13/2739

摘要： Address generation by an integrated circuit is described. An aspect relates generally to an address generator which has first and second processing units. The second processing unit is coupled to receive a stage output from the first processing unit and configured to provide an address output. The stage output is in a first range, and the address output is in a second range. The first range is from −K to −1 for K a block size, and the second range is from 0 to K-1.

摘要翻译： 描述了由集成电路产生的地址。 一方面涉及具有第一和第二处理单元的地址发生器。 第二处理单元被耦合以从第一处理单元接收级输出并且被配置为提供地址输出。 舞台输出处于第一范围，地址输出处于第二范围。 对于K块，第一个范围从-K到-1，第二个范围是从0到K-1。

公开(公告)号：US07416847B1

公开(公告)日：2008-08-26

申请号：US09331808

申请日：1998-02-18

申请人： Bjorn H. Lindqvist ,  David Andrews ,  Elizabeth Haggard-Ljungquist ,  Morten Isaksen

发明人： Bjorn H. Lindqvist ,  David Andrews ,  Elizabeth Haggard-Ljungquist ,  Morten Isaksen

IPC分类号： G01N33/53 ,  C40B30/04

CPC分类号： C07K14/005 ,  C12N15/1075 ,  C12N2795/10122

摘要： The present invention relates to methods of producing peptide or protein expression libraries. In such a library, a population of nucleotide sequences is expressed. The resulting peptides or proteins encoded by those nucleotide sequences are then screened to identify those peptides or proteins having a desired property such as the ability to bind a selected ligand. In the construction and screening of such libraries, it is desired to ensure that the nucleotide encoding a particular protein remains connected in some way with that protein so that once a desired protein having a selected property has been isolated, its encoding nucleotide sequence may be specifically recovered for subsequent manipulation for example using PCR or sequencing. The present invention makes use of a property not previously described in constructing an expression library namely the use of proteins which covalently bind DNA. DNA is expressed in such a way that the protein so expressed binds to its own encoding DNA therefore allowing the DNA to be associated only with its encoding protein.

摘要翻译： 本发明涉及产生肽或蛋白质表达文库的方法。 在这样的文库中，表达了核苷酸序列的群体。 然后筛选由所述核苷酸序列编码的所得肽或蛋白质以鉴定具有所需性质的那些肽或蛋白质，例如结合所选择的配体的能力。 在这样的文库的构建和筛选中，希望确保编码特定蛋白的核苷酸以某种方式与该蛋白质相连，使得一旦已经分离了具有选定性质的所需蛋白质，其编码核苷酸序列可以是特异性的 回收用于随后的操作，例如使用PCR或测序。 本发明利用以前在构建表达文库中所述的性质，即使用共价结合DNA的蛋白质。 以这样的方式表达DNA，使得如此表达的蛋白质与其自身的编码DNA结合，从而允许DNA与其编码蛋白质相关联。

公开(公告)号：US20070161615A1

公开(公告)日：2007-07-12

申请号：US10586954

申请日：2005-01-31

申请人： David Andrews ,  Maurice Finlay ,  Clive Green

发明人： David Andrews ,  Maurice Finlay ,  Clive Green

IPC分类号： A61K31/55 ,  A61K31/655 ,  A61K31/506 ,  C07D403/14

CPC分类号： C07D403/04 ,  C07D403/14

摘要： Compounds of the formula (I), wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.

摘要翻译： 描述了式（I）化合物，其中可变基团如本文所定义，以及药学上可接受的盐和体内可水解的酯。 还描述了其制备方法及其作为药物的用途，特别是用于在温血动物如人中产生细胞周期抑制（抗细胞增殖）作用的药物。

公开(公告)号：US20070140919A1

公开(公告)日：2007-06-21

申请号：US10539306

申请日：2003-12-17

申请人： John Clarkson ,  David Andrews

发明人： John Clarkson ,  David Andrews

IPC分类号： B01L3/00

CPC分类号： B01L3/5082 ,  B01L3/50851 ,  B01L2200/12 ,  B01L2300/0858 ,  B29C33/44 ,  B29C45/0046 ,  B29K2023/38

摘要： The invention provides a method of making a sample vessel comprising: (a) melting a plastics material (b) introducing the molten plastics material into a mold, and (c) allowing the plastics material to set in the mold; wherein the mold defines a cavity with the shape of a sample vessel which comprises a tubular portion, which tubular portion has a maximum external cross sectional width of up to 5 mm and an internal sample volume of up to 100 μl wherein the tubular portion comprises a tubular external wall with a thickness of from 0.01 to 2 mm.

摘要翻译： 本发明提供了一种制造样品容器的方法，包括：（a）熔化塑料材料（b）将熔融塑料材料引入模具，和（c）使塑料材料放置在模具中; 其中所述模具限定具有样品容器形状的空腔，所述腔体包括管状部分，所述管状部分具有高达5mm的最大外部横截面宽度和至多100微米的内部样品体积，其中所述管状部分包括 管状外壁厚度为0.01至2mm。

公开(公告)号：US20070056374A1

公开(公告)日：2007-03-15

申请号：US11427830

申请日：2006-06-30

申请人： David Andrews

发明人： David Andrews

IPC分类号： G01N29/04

CPC分类号： G01N29/4418 ,  G01N29/449 ,  G01N33/383 ,  G01N2291/044 ,  G01N2291/105

摘要： A monitoring system uses sound waves and/or ultrasound waves that are emitted into a structure being monitored from one or more monitoring devices and echo-waves from the interior and surface of the structure are received at one or more monitoring devices at locations of importance to the stability and operational worthiness of the structure. Received signals from echo-waves are processed so that operational noise is largely eliminated or reduced to an acceptable level then collected and stored or archived; newly received and processed signals are also compared with existing archive signals and a decision is made for each new signal if it is representative of the structure being unchanged or representative of the structure after significant structural change has occurred. Results of decisions at locations of interest are combined to give a graded risk for the structure as a whole as well as identifying specific locations of significant structural change. An operator is warned when a threshold risk is reached allowing response actions to be initiated, for example: safety procedures and/or repair procedures.

摘要翻译： 监测系统使用声波和/或超声波，其发射到从一个或多个监测装置监测的结构中，并且来自结构的内部和表面的回波在一个或多个监测装置处被接收在重要的位置处 结构的稳定性和运行价值。 来自回波的接收信号被处理，使得操作噪声被很大程度上消除或降低到可接受的水平，然后被收集和存储或归档; 新接收和处理的信号也与现有归档信号进行比较，并且如果代表结构不变或在发生重大结构变化之后的结构的代表，则对每个新信号做出决定。 将感兴趣的地点的决策结果相结合，为结构整体提供分级风险，并确定重大结构变化的具体位置。 当达到阈值风险时，会向操作员发出警告，允许启动响应动作，例如：安全程序和/或维修程序。

公开(公告)号：US20060222682A1

公开(公告)日：2006-10-05

申请号：US11384213

申请日：2006-03-16

申请人： David Andrews

发明人： David Andrews

IPC分类号： A61K36/185 ,  A61K47/00 ,  A61K9/48 ,  A61K9/20

CPC分类号： A61K36/185 ,  A23L33/105 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention incorporates portions from the Moringa plant into a nutraceutical beverage to provide a therapeutic effect in a person. The leaves, seeds, and fruit of the Moringa plant are used in the present invention to provide a biologically metabolized nutritional composition for health, well-being, and for treatment of ailments.

摘要翻译： 本发明将来自Moringa植物的部分掺入营养饮料中以在人体中提供治疗效果。 Moringa植物的叶子，种子和果实用于本发明以提供用于健康，幸福和治疗疾病的生物代谢营养组合物。

公开(公告)号：US20060001250A1

公开(公告)日：2006-01-05

申请号：US11043155

申请日：2005-01-27

申请人： Kazumasa Fukazawa ,  David Andrews ,  Masayuki Mukaino

发明人： Kazumasa Fukazawa ,  David Andrews ,  Masayuki Mukaino

IPC分类号： B62D21/00

CPC分类号： B62D55/06 ,  B62D55/125 ,  B62D55/32

摘要： A main frame 2 used for a construction machine having a working machine, in which a traveling unit 3 is attached to a side extending along a posterior-anterior direction of the construction machine, and the working machine is attached to a front portion and/or rear portion of the construction machine includes a plurality of frame modules 21, 22, 23, 24 arranged in the posterior-anterior direction of the construction machine with respective end surfaces jointed to each other, in which the frame modules 22, 24 disposed at a position where a loading is applied among the plurality of frame modules 21, 22, 23, 24 are formed by integral casting.

摘要翻译： 用于具有作业机械的施工机械的主框架2，其中将行进单元3安装在沿着建筑机械的前后方向延伸的一侧和工作机械的前部和/或 建筑机械的后部包括多个框架模块21,22,23,24，其布置在建筑机械的后部前方，其相应的端面彼此接合，其中框架模块22,24设置在其上 通过一体铸造形成在多个框架模块21,22,23,24之间施加载荷的位置。

公开(公告)号：US10422103B2

公开(公告)日：2019-09-24

申请号：US13860093

申请日：2013-04-10

申请人： Bruce Alexander Leslie ,  Bevan Hall ,  Simon Peter Orton ,  Derek Mulder ,  David Andrews

发明人： Bruce Alexander Leslie ,  Bevan Hall ,  Simon Peter Orton ,  Derek Mulder ,  David Andrews

IPC分类号： E02F3/40 ,  E02F3/60

摘要： A heavy duty excavator bucket is constructed with an exoskeletal structure comprising coupled cast components including a lip member, opposed wing members, junction members locatable between floor and side walls and side and rear walls and a cap rail structure extending between opposed wing members about the upper periphery of the bucket to form an integral structure. Steel plate floor, side wall and rear wall members extend between adjacent exoskeletal regions. The bucket may include a cast arch member extending between opposed wing members and a cast reinforcing member extending between opposed junction members adjacent said rear wall.