公开(公告)号：US20070107524A1

公开(公告)日：2007-05-17

申请号：US11582669

申请日：2006-10-18

Applicant: David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

Inventor： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

IPC: G01L9/00

CPC classification number: G01L9/0073

Abstract: An exemplary pressure cavity is disclosed that is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The exemplary pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from ambient pressure in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g., intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Abstract translation: 公开了一种示例性的压力腔，其是耐用的，稳定的和生物相容的并且以这样的方式配置，使得其构成微微至纳升级体积。 示例性压力腔与外部环境气密密封，同时保持与其他装置通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境压力密封，以减少传感器内的漂移和不稳定性。 传感器设计用于恶劣和生物环境，例如体内植入和体内使用。 另外，采用新的制造方法构造传感器。

公开(公告)号：US20060168379A1

公开(公告)日：2006-07-27

申请号：US11011301

申请日：2004-12-13

Applicant: Tim Frodsham ,  Michael Tripp ,  David O'Brien ,  Navada Muraleedhara ,  Naveen Cherukuri ,  Sanjay Dabral ,  David Dunning ,  Theodore Schoenborn

Inventor： Tim Frodsham ,  Michael Tripp ,  David O'Brien ,  Navada Muraleedhara ,  Naveen Cherukuri ,  Sanjay Dabral ,  David Dunning ,  Theodore Schoenborn

IPC: G06F13/00

CPC classification number: G06F1/06 ,  G06F13/362 ,  H04L43/50

Abstract: A link latency management for a high-speed point-to-point network (pTp) is described The link latency management facilitates calculating latency of a serial interface by tracking a round trip delay of a header that contains latency information. Therefore, the link latency management facilitates testers, logic analyzers, or test devices to accurately measure link latency for a point-to-point architecture utilizing a serial interface.

Abstract translation: 描述了用于高速点对点网络（pTp）的链路延迟管理。链路延迟管理有助于通过跟踪包含延迟信息的报头的往返延迟来计算串行接口的延迟。 因此，链路延迟管理便于测试人员，逻辑分析仪或测试设备使用串行接口准确测量点对点架构的链路延迟。

公开(公告)号：US20060120343A1

公开(公告)日：2006-06-08

申请号：US10997137

申请日：2004-11-24

Applicant: David O'Brien ,  Vikram Yashpal ,  Greg Nissley

Inventor： David O'Brien ,  Vikram Yashpal ,  Greg Nissley

IPC: H04L12/28

CPC classification number: H04L51/14 ,  H04L12/1859 ,  H04L51/38 ,  H04W4/18 ,  H04W8/18

Abstract: System for message delivery to field personnel. The system includes a method for operating a server in a message delivery system. The method includes receiving a message for transmission to a recipient, and determining a message characteristic associated with the message. The method also includes obtaining contact information associated with the recipient based on the message characteristic, and transmitting the message to the recipient using a communication method indicated by the contact information.

Abstract translation: 向现场人员发送消息的系统。 该系统包括用于在消息传递系统中操作服务器的方法。 该方法包括接收用于发送给接收者的消息，以及确定与该消息相关联的消息特征。 该方法还包括基于消息特征获得与接收者相关联的联系人信息，并且使用由联系人信息指示的通信方法将消息发送到接收者。

公开(公告)号：US20060099141A1

公开(公告)日：2006-05-11

申请号：US11317833

申请日：2005-12-22

Applicant: David O'Brien ,  Kathy McGovern ,  Bruce Bondurant ,  Robert Sutherland

Inventor： David O'Brien ,  Kathy McGovern ,  Bruce Bondurant ,  Robert Sutherland

IPC: A61K51/00 ,  A61K9/127

CPC classification number: A61K9/0009 ,  A61K9/1273

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract translation: 本发明涉及一种辐射敏感性脂质体，以及该脂质体作为治疗和诊断剂的载体的用途。 特别地，本发明包括脂质体递送系统，其包含稳定的形成脂质体的脂质和可聚合的脂肪，其可聚合的脂肪酸在暴露于电离，辐射时聚合，从而使脂质体膜失稳。 脂质体的不稳定性允许脂质体内容物的泄漏。 本发明还考虑了诊断和治疗对脂质体包封或相关药物有反应的病症和疾病的方法。

公开(公告)号：US20060033378A1

公开(公告)日：2006-02-16

申请号：US11200673

申请日：2005-08-10

Applicant: Darren Sargent ,  David O'Brien

Inventor： Darren Sargent ,  David O'Brien

IPC: B62B1/00

CPC classification number: B60P1/14 ,  B60P1/283 ,  B60P1/34 ,  B62D63/061 ,  B62D63/062

Abstract: A bin 1 mounted on wheels is disclosed. The bin 1 comprises a support 2 having a pair of wheels 3 mounted there to. The support 2 also has a brake that can be selectively engaged by an operator to brake the wheels. A bin container 5 is rigidly mounted on the support 2. The bin container 5 comprises a front and a rear 10 and 12 and two sides 13, 14 extending between the front and the rear. The rear 12 forms a tailgate that is capable of being moved from a closed position in which it closes off the front and sides and an open position in which it defines an opening in the wall. Material such as soil or refuse can be loaded into the bin container 5 and discharged from the bin container through this opening. The bin 1 includes a draw pole 25 for attaching it to a towing vehicle. The bin container 5 can be tipped from a travelling position to a rearward tipping position in which the bin container 5 slopes down in a rearward direction by applying the brake to the at least one wheel 3 and then displacing the draw pole 25 rearward. This causes the draw pole 25 to pivot the bin 1. The tailgate 12 also includes a chain extending from the draw pole 25 to the tailgate 12 that automatically moves the tailgate 12 from the closed to the open position in response to tipping of the bin container 5 into the rearward tipping position.

Abstract translation: 公开了一种安装在车轮上的垃圾桶1。 货箱1包括具有安装在那里的一对车轮3的支撑件2。 支撑件2还具有可由操作者选择性地接合以制动车轮的制动器。 垃圾桶容器5刚性地安装在支撑件2上。垃圾桶容器5包括前部和后部10和12以及在前部和后部之间延伸的两个侧面13,14。 后部12形成后挡板，该后挡板能够从闭合位置移动，其中闭合位置将其封闭在前侧和侧面以及打开位置，在该位置中其限定了壁中的开口。 诸如土壤或垃圾的材料可以装载到垃圾箱容器5中，并通过该开口从垃圾桶容器排出。 货箱1包括用于将其连接到拖车的拉杆25。 容器容器5可以从行进位置倾斜到向后倾斜位置，通过将制动器施加到至少一个车轮3并且然后使抽屉杆25向后移动，容器5在向后方向上向下倾斜。 这使得拉杆25枢转料仓1.后挡板12还包括从拉杆25延伸到后挡板12的链条，该链条响应于料斗容器的倾斜而将尾板12自动地从关闭位置移动到打开位置 5进入向后倾斜位置。

公开(公告)号：USD302661S

公开(公告)日：1989-08-08

申请号：US240902

申请日：1988-09-02

Applicant: Victor Calcerano ,  David O'Brien

Designer： Victor Calcerano ,  David O'Brien

公开(公告)号：US20130066647A1

公开(公告)日：2013-03-14

申请号：US13603452

申请日：2012-09-05

Applicant: Matthew J. Andrie ,  Timothy A. Beardsley ,  Beth Bissonnette ,  Brett Patrick Knickerbocker ,  Adam LaWare ,  Bradley Moore ,  David O'Brien ,  Christopher Rigsby

Inventor： Matthew J. Andrie ,  Timothy A. Beardsley ,  Beth Bissonnette ,  Brett Patrick Knickerbocker ,  Adam LaWare ,  Bradley Moore ,  David O'Brien ,  Christopher Rigsby

IPC: G06Q50/22

CPC classification number: G06Q10/06311 ,  G06F19/328 ,  G06F19/3481 ,  G06Q10/06314 ,  G06Q50/22 ,  G16H40/20

Abstract: Systems and methods are disclosed herein that generally provide a new model for surgical support and management. Tasks typically performed in advance of and following a surgery can be performed in an automated and efficiency-optimized manner, particularly in the case of routine or straightforward surgical procedures. In one embodiment, the various parties involved in a surgery can access a surgical support and management system using one or more web pages. The system can perform various tasks associated with the surgical planning, inventory planning, intra-operative support, post-surgery logistics, and billing phases of surgical support and management.

Abstract translation: 本文公开的系统和方法通常提供用于外科支持和管理的新模型。 通常在手术之前和之后进行的任务可以以自动化和效率优化的方式进行，特别是在常规或简单的外科手术的情况下。 在一个实施例中，参与手术的各方可以使用一个或多个网页访问外科支持和管理系统。 该系统可以执行与手术规划，库存计划，手术内支持，手术后物流以及外科支持和管理计费阶段相关的各种任务。

公开(公告)号：US07990964B2

公开(公告)日：2011-08-02

申请号：US10997137

申请日：2004-11-24

Applicant: David O'Brien ,  Vikram Yashpal ,  Greg Nissley

Inventor： David O'Brien ,  Vikram Yashpal ,  Greg Nissley

IPC: H04L12/28

CPC classification number: H04L51/14 ,  H04L12/1859 ,  H04L51/38 ,  H04W4/18 ,  H04W8/18

Abstract: System for message delivery to field personnel. The system includes a method for operating a server in a message delivery system. The method includes receiving a message for transmission to a recipient, and determining a message characteristic associated with the message. The method also includes obtaining contact information associated with the recipient based on the message characteristic, and transmitting the message to the recipient using a communication method indicated by the contact information.

Abstract translation: 向现场人员发送消息的系统。 该系统包括用于在消息传递系统中操作服务器的方法。 该方法包括接收用于发送给接收者的消息，以及确定与该消息相关联的消息特征。 该方法还包括基于消息特征获得与接收者相关联的联系信息，并且使用由联系人信息指示的通信方法将消息发送到接收者。

公开(公告)号：US07748277B2

公开(公告)日：2010-07-06

申请号：US11582669

申请日：2006-10-18

Applicant: David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

Inventor： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

IPC: G01L9/00 ,  G01L9/12 ,  G01L9/06

CPC classification number: G01L9/0073

Abstract: An exemplary pressure cavity is disclosed that is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The exemplary pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from ambient pressure in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g., intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Abstract translation: 公开了一种示例性的压力腔，其是耐用的，稳定的和生物相容的并且以这样的方式配置，使得其构成微微至纳升级体积。 示例性压力腔与外部环境气密密封，同时保持与其他装置通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境压力密封，以减少传感器内的漂移和不稳定性。 传感器设计用于恶劣和生物环境，例如体内植入和体内使用。 另外，采用新的制造方法构造传感器。

公开(公告)号：US07662653B2

公开(公告)日：2010-02-16

申请号：US11314696

申请日：2005-12-20

Applicant: David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

Inventor： David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

IPC: H01L21/00

CPC classification number: G01L9/0075 ,  A61B5/03 ,  A61B2562/0247 ,  B81B7/007 ,  B81B2201/0264 ,  B81B2201/06 ,  B81B2207/096 ,  B81C1/00301 ,  G01L9/0073

Abstract: A method of manufacturing a hermetically-sealed chamber with an electrical feedthrough includes the step of hermetically fixing an electrode to a substrate in a predetermined location on the substrate. A passage is formed through the substrate through the predetermined location such that at least a portion of the electrode is exposed to the passage. The passage is then at least partially filled with an electrically conductive material. A housing is then formed including the substrate such that the housing defines a chamber, with the electrode being disposed within the housing and the chamber being hermetically sealed. The electrode within the chamber can be placed in electrical communication with an exterior electrical component by way of the electrically conductive material in the passage.

Abstract translation: 制造具有电馈通的气密密封室的方法包括将电极气密固定在基板上的预定位置上的步骤。 通过基板穿过预定位置形成通道，使得电极的至少一部分暴露于通道。 然后通道至少部分地填充有导电材料。 然后形成包括基板的壳体，使得壳体限定室，其中电极设置在壳体内，并且室被气密地密封。 室内的电极可以通过通道中的导电材料与外部电气部件电连接。