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31 条记录 (耗时 0.025 秒)

    Controlled release formulation for water soluble drugs in which a passageway is formed in situ
    11.
    发明授权
    Controlled release formulation for water soluble drugs in which a passageway is formed in situ 失效
    水溶性药物的控制释放制剂，其中通道原位形成

    公开(公告)号：US5558879A

    公开(公告)日：1996-09-24

    申请号：US431404

    申请日：1995-04-28

    申请人： Chih-Ming Chen ,  Der-Yang Lee

    发明人： Chih-Ming Chen ,  Der-Yang Lee

    IPC分类号： A61K9/48 ,  A61K9/00 ,  A61K9/16 ,  A61K9/22 ,  A61K9/24 ,  A61K9/36 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K9/56 ,  A61K31/135 ,  A61K31/137

    CPC分类号： A61K9/209 ,  A61K31/137 ,  A61K9/0004 ,  A61K9/1652 ,  A61K9/5047 ,  Y10S514/853 ,  Y10S514/96

    摘要： A controlled release pharmaceutical tablet is disclosed which is based on:(a) a compressed core which contains:(i) a medicament;(ii) from 5 to 20% by weight of a water soluble osmotic agent based on the total weight of the compressed core;(iii) a water soluble pharmaceutically acceptable polymeric binder;(iv) a conventional pharmaceutical excipient; and(b) a dual layer membrane coating around said core which consists essentially of:(i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and;(ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer.The controlled release formulation is suitable for the once-a-day administration of medicaments.

    摘要翻译： 公开了一种控释药物片剂，其基于：（a）压缩核心，其包含：（i）药物; （ii）基于压缩芯的总重量的5至20重量％的水溶性渗透剂; （iii）水溶性药学上可接受的聚合物粘合剂; （iv）常规药物赋形剂; 和（b）围绕所述芯的双层膜涂层，其基本上由以下部分组成：（i）用于药物持续释放的第一内包衣层，所述内包衣层基本上由塑化水不溶性药学上可接受的聚合物和药学上可接受的 水溶性聚合物，和; （ii）用于立即释放药物的第二外涂层，所述外涂层基本上由有效量的药物和水溶性聚合物组成。 控制释放制剂适合于每天一次的药物施用。

    Coated particles containing pharmaceutically active agents
    12.
    发明授权
    Coated particles containing pharmaceutically active agents 有权
    含有药物活性剂的包衣颗粒

    公开(公告)号：US08282957B2

    公开(公告)日：2012-10-09

    申请号：US12490465

    申请日：2009-06-24

    申请人： Robert Shen ,  Vincent Chen ,  Der-Yang Lee

    发明人： Robert Shen ,  Vincent Chen ,  Der-Yang Lee

    IPC分类号： A61K9/26

    CPC分类号： A61K9/2081 ,  A61K9/5078

    摘要： The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.

    摘要翻译： 本发明的特征在于包含含有药物活性剂的颗粒的片剂，其中所述颗粒涂覆有（a）含有改性释放聚合物的第一膜层; 和（b）含有（i）第一聚合物的第二膜层，其中第一聚合物是丙烯酸乙酯和甲基丙烯酸甲酯的聚合物和（ii）第二聚合物，其中第二聚合物是丙烯酸甲酯，甲基丙烯酸甲酯 和甲基丙烯酸。

    OSMOTIC TABLET WITH A COMPRESSED OUTER COATING
    15.
    发明申请
    OSMOTIC TABLET WITH A COMPRESSED OUTER COATING 审中-公开
    具有压缩外涂层的OSMOTIC板

    公开(公告)号：US20100112052A1

    公开(公告)日：2010-05-06

    申请号：US12607248

    申请日：2009-10-28

    申请人： Vincent Chen ,  Shun-Por Li ,  Robert Shen ,  Der-Yang Lee

    发明人： Vincent Chen ,  Shun-Por Li ,  Robert Shen ,  Der-Yang Lee

    IPC分类号： A61K9/22 ,  A61K31/135 ,  A61K31/495

    CPC分类号： A61K9/209 ,  A61K9/0004

    摘要： The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent.

    摘要翻译： 本发明的特征在于一种制造渗透性片剂的方法，包括以下步骤：（i）压缩包含第一药物活性剂和亲水性聚合物的片芯; （ii）将渗透涂层施加到片芯的外表面以形成包衣片，其中所述渗透涂层包括暴露片芯的至少一个开口; 和（iii）将即时释放涂层压缩到所述包衣片剂的表面上，其中所述剥离包衣包含第二药物活性剂。

    METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS
    16.
    发明申请
    METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS 审中-公开
    制造改良释放剂量形式的方法

    公开(公告)号：US20090186082A1

    公开(公告)日：2009-07-23

    申请号：US12360579

    申请日：2009-01-27

    申请人： Shun-Por LI ,  David Wynn ,  Narendra Parikh ,  Dan McTeigue ,  Harry S. Sowden ,  Martin Thomas ,  Der-Yang Lee

    发明人： Shun-Por LI ,  David Wynn ,  Narendra Parikh ,  Dan McTeigue ,  Harry S. Sowden ,  Martin Thomas ,  Der-Yang Lee

    IPC分类号： A61K9/22

    CPC分类号： A61J3/10 ,  A23G3/04 ,  A23G3/368 ,  A61J3/005 ,  A61K9/2853 ,  A61K9/2873 ,  A61K9/2893 ,  B30B11/08 ,  B30B11/34

    摘要： In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.

    摘要翻译： 在一个实施方案中，剂型包含：（a）至少一种活性成分; （b）在室温下为固体的模制芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。 在本发明的另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）包含多个颗粒的成型芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。

    METHOD OF MAKING DOSAGE FORMS COMPRISING POLYMERIC COMPOSITIONS
    17.
    发明申请
    METHOD OF MAKING DOSAGE FORMS COMPRISING POLYMERIC COMPOSITIONS 审中-公开
    制备包含聚合物组合物的剂型的方法

    公开(公告)号：US20080206337A1

    公开(公告)日：2008-08-28

    申请号：US12061765

    申请日：2008-04-03

    申请人： Hai Yong Huang ,  Der-Yang Lee ,  Shun Por Li

    发明人： Hai Yong Huang ,  Der-Yang Lee ,  Shun Por Li

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0004 ,  A61K9/286 ,  A61K9/2866 ,  A61K31/137

    摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium. At least a portion of the shell may be comprised of a polymeric composition containing film former, gelling agents, which can be dissolved in a multisolvent system comprised of water and an organic solvent.

    摘要翻译： 剂型包括：（a）至少一种活性成分; （b）具有外表面的芯; 和（c）位于所述芯外表面的至少一部分上的壳，其中所述壳的至少一部分是半透性的，使得所述液体介质由于渗透而扩散通过所述半透性壳或壳部分到所述芯。 壳体还提供了在剂型与液体介质接触之后将活性成分递送到壳外的液体介质。 剂型在剂型与液体培养基接触时以受控的方式递送一种或多种活性成分。 剂型可以用于提供活性成分的爆发释放，或者当剂型与液体介质接触时，在延长的释放速率下提供活性成分的释放。 壳的至少一部分可以由含有成膜剂，胶凝剂的聚合物组合物组成，其可以溶解在由水和有机溶剂组成的多溶剂体系中。

    Polymeric compositions and dosage forms comprising the same
    18.
    发明申请
    Polymeric compositions and dosage forms comprising the same 审中-公开

    公开(公告)号：US20050196447A1

    公开(公告)日：2005-09-08

    申请号：US10794659

    申请日：2004-03-05

    申请人： Hai Huang ,  Der-Yang Lee ,  Shun Li

    发明人： Hai Huang ,  Der-Yang Lee ,  Shun Li

    IPC分类号： A61K9/24 ,  A61K9/66

    CPC分类号： A61K9/286 ,  A61K9/0004 ,  A61K9/2866

    摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium. At least a portion of the shell may be comprised of a polymeric composition containing film former, gelling agents, which can be dissolved in a multisolvent system comprised of water and an organic solvent.

    Modified release dosage forms
    19.
    发明授权
    Modified release dosage forms 有权
    改性释放剂型

    公开(公告)号：US08545887B2

    公开(公告)日：2013-10-01

    申请号：US10476530

    申请日：2002-09-28

    申请人： Harry S. Sowden ,  David Wynn ,  Shun-Por Li ,  Der-Yang Lee ,  Martin Thomas

    发明人： Harry S. Sowden ,  David Wynn ,  Shun-Por Li ,  Der-Yang Lee ,  Martin Thomas

    IPC分类号： A61J3/06 ,  A61K9/20 ,  B30B11/00 ,  A61K9/24 ,  G06F17/30

    CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

    摘要： A dosage form comprises: (a) at least one active ingredient: (b) a core having a first surface portion upon which resides a first coating and a second surface portion which is substantially free of the first coating; and (c) a shell which resides upon at least a portion of the second surface portion, wherein the shell comprises a different material from the first coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising a center portion having an exterior surface and an annular portion having an exterior surface and an interior surface, wherein the annular portion interior surface is in contact with at least a portion of the center portion exterior surface, and a coating resides on at least a portion of the annular portion exterior surface; and (c) a shell which resides upon at least a portion of the exterior surface of the center portion, wherein the shell comprises a different material than the impermeable coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface and a cavity which extends at least partially through the core such that the core outer surface has at least a first opening therein; (c) a first coating which resides on at least a portion of the core outer surface, wherein the first shell portion comprises a different material from the first coating; and (d) a first shell portion which is adjacent to the first opening and covers at least the first opening.

    摘要翻译： 剂型包括：（a）至少一种活性成分：（b）具有第一表面部分的核心，其上存在第一涂层和基本上不含第一涂层的第二表面部分; 和（c）位于第二表面部分的至少一部分上的外壳，其中外壳包括与第一涂层不同的材料。 在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）芯部，其包括具有外表面的中心部分和具有外表面和内表面的环形部分，其中所述环形部分内表面与所述中心部分外表面的至少一部分接触， 位于环形部分外表面的至少一部分上; 和（c）驻留在中心部分的外表面的至少一部分上的壳体，其中壳体包括与不可渗透涂层不同的材料。 在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）具有外表面和空腔的芯体，其至少部分地穿过所述芯部，使得所述芯部外表面至少具有第一开口; （c）驻留在所述芯外表面的至少一部分上的第一涂层，其中所述第一壳部分包括与所述第一涂层不同的材料; 和（d）与第一开口相邻并且至少覆盖第一开口的第一壳体部分。