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公开(公告)号：US08337824B2
公开(公告)日：2012-12-25
申请号：US12545810
申请日：2009-08-22
申请人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
发明人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
IPC分类号： A61K47/10 , A61K31/75 , A61K31/755 , A61K31/785 , A61K31/047 , C08F220/22 , C08F220/04 , C08F299/00 , C08F236/00 , C08F236/20 , C08F230/02
CPC分类号： A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要： The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及线性多元醇和包含氟基团和酸基团的交联阳离子交换聚合物的盐的组合物。 这些组合物可用于结合胃肠道中的钾。
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公开(公告)号：US07854924B2
公开(公告)日：2010-12-21
申请号：US10814527
申请日：2004-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US07488495B2
公开(公告)日：2009-02-10
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US20080241093A1
公开(公告)日：2008-10-02
申请号：US12055746
申请日：2008-03-26
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US07429394B2
公开(公告)日：2008-09-30
申请号：US11095918
申请日：2005-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐失衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过量。
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公开(公告)号：US20050220889A1
公开(公告)日：2005-10-06
申请号：US10813872
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/50
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20050220752A1
公开(公告)日：2005-10-06
申请号：US11096209
申请日：2005-03-30
申请人： Dominique Charmot , Han Chang , Gerrit Klaerner , Michael Cope , Mingjun Liu , Futian Liu , Kwok-Kong Mong
发明人： Dominique Charmot , Han Chang , Gerrit Klaerner , Michael Cope , Mingjun Liu , Futian Liu , Kwok-Kong Mong
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US08216560B2
公开(公告)日：2012-07-10
申请号：US12055726
申请日：2008-03-26
申请人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
发明人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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19.发明授权公开(公告)号：US07465439B2
公开(公告)日：2008-12-16
申请号：US10542421
申请日：2003-12-29
申请人： Andrew Richard Avery , Dominique Charmot , Jean M Frechet , Damian Hajduk , Ezat Khoshdel , Mingjun Liu
发明人： Andrew Richard Avery , Dominique Charmot , Jean M Frechet , Damian Hajduk , Ezat Khoshdel , Mingjun Liu
CPC分类号： C11D3/3742 , A61K8/894 , A61K8/91 , A61K2800/54 , A61Q5/00 , A61Q5/12 , A61Q19/00 , C11D3/373
摘要： A composition for personal, home, or laundry treatment comprising a polymer made up of one or more crosslinked rake or comb silicone copolymer segments. A process for making copolymers for use in such compositions involves hydrosilylation in the presence of a catalyst.
摘要翻译： 一种用于个人，家庭或衣物处理的组合物，其包含由一种或多种交联的耙式或梳状硅氧烷共聚物片段组成的聚合物。 制备用于这种组合物的共聚物的方法包括在催化剂存在下的氢化硅烷化。
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公开(公告)号：US20050220751A1
公开(公告)日：2005-10-06
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Chang , Gerrit Klaerner , Michael Cope , Mingjun Liu , Futian Liu
发明人： Dominique Charmot , Han Chang , Gerrit Klaerner , Michael Cope , Mingjun Liu , Futian Liu
IPC分类号： A61K31/74 , A61K31/785
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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