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公开(公告)号：US20140356316A1
公开(公告)日：2014-12-04
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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2.发明授权Pharmaceutical compositions comprising cross-linked small molecule amine polymers 失效包含交联的小分子胺聚合物的药物组合物公开(公告)号：US07608674B2
公开(公告)日：2009-10-27
申请号：US10980991
申请日：2004-11-03
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US09655920B2
公开(公告)日：2017-05-23
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02 , A61K45/06
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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4.发明授权Treatment of hyperphosphatemia using crosslinked small molecule amine polymers 失效使用交联的小分子胺聚合物治疗高磷酸盐血症公开(公告)号：US07589238B2
公开(公告)日：2009-09-15
申请号：US11465444
申请日：2006-08-17
申请人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klaemer , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klaemer , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C07C211/11 , C08G2/00
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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5.发明授权Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants 有权交联聚乙烯胺，聚烯丙胺和聚乙烯亚胺，用作胆汁酸螯合剂公开(公告)号：US09181364B2
公开(公告)日：2015-11-10
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785 , C08F20/52 , C08F22/38 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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公开(公告)号：US20100029897A1
公开(公告)日：2010-02-04
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08G73/00
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US07488495B2
公开(公告)日：2009-02-10
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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8.发明申请CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权交联的聚乙烯胺，聚甲基丙烯酸和聚乙烯亚胺作为双酸序列使用公开(公告)号：US20130022570A1
公开(公告)日：2013-01-24
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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公开(公告)号：US07718746B2
公开(公告)日：2010-05-18
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08F26/06 , C07C211/11
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不能用于高于聚合物的目标离子的一定百分比MW的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US20130189215A1
公开(公告)日：2013-07-25
申请号：US13581102
申请日：2011-02-24
申请人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： C08F226/06 , A61K45/06 , C08G73/06 , A61K31/787
CPC分类号： C08F226/06 , A61K31/155 , A61K31/397 , A61K31/785 , A61K31/787 , A61K45/06 , C08G73/0273 , C08G73/0616 , C08G73/0627 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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