-
公开(公告)号：US07556799B2
公开(公告)日：2009-07-07
申请号：US11096209
申请日：2005-03-30
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
-
公开(公告)号：US07342083B2
公开(公告)日：2008-03-11
申请号：US10980935
申请日：2004-11-03
申请人： Han Ting Chang , Dominique Charmot , Samir Zard
发明人： Han Ting Chang , Dominique Charmot , Samir Zard
IPC分类号： C08F12/28
CPC分类号： C08F26/06
摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.
摘要翻译： 本发明提供包含含有连位胺部分的聚合物的聚合物和药物组合物，称为聚酰胺胺聚合物。 聚酰胺可以是共聚物或均聚物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病，高磷血症，以及从胃肠道中除去胆汁酸，草酸盐和铁。
-
公开(公告)号：US07335795B2
公开(公告)日：2008-02-26
申请号：US10806495
申请日：2004-03-22
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
IPC分类号： C07C211/11
CPC分类号： C08G73/02 , C08G73/0206
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供包含交联胺聚合物的聚合物和药物组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病和高磷酸血症。
-
公开(公告)号：US07854924B2
公开(公告)日：2010-12-21
申请号：US10814527
申请日：2004-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
-
公开(公告)号：USRE41316E1
公开(公告)日：2010-05-04
申请号：US12163767
申请日：2008-06-27
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
IPC分类号： C07C211/11
CPC分类号： C08G73/02 , C08G73/0206
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
-
公开(公告)号：US07488495B2
公开(公告)日：2009-02-10
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
-
公开(公告)号：US07449605B2
公开(公告)日：2008-11-11
申请号：US11088271
申请日：2005-03-22
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
IPC分类号： C07C211/11
CPC分类号： A61K31/785 , A61K31/132 , C08G73/02 , C08G73/0206 , C08L39/02 , C08L2666/02
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
-
公开(公告)号：US07429394B2
公开(公告)日：2008-09-30
申请号：US11095918
申请日：2005-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐失衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过量。
-
公开(公告)号：US07012119B2
公开(公告)日：2006-03-14
申请号：US10407405
申请日：2003-04-03
申请人： Dominique Charmot , Han Ting Chang , Wenyue Wang , Marcelo Piotti
发明人： Dominique Charmot , Han Ting Chang , Wenyue Wang , Marcelo Piotti
CPC分类号： C08F2/38
摘要： A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.
-
20.发明授权公开(公告)号：US06844407B2
公开(公告)日：2005-01-18
申请号：US10407614
申请日：2003-04-03
申请人： Dominique Charmot , Han Ting Chang , Wenyue Wang
发明人： Dominique Charmot , Han Ting Chang , Wenyue Wang
IPC分类号： C07D231/10 , C07C337/02 , C07C337/04 , C07D285/125 , C08F2/00 , C08F2/38 , C08F4/00 , C08F4/04 , C08F8/00 , C07C333/00
CPC分类号： C08F2/38
摘要： Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.033 秒)
