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公开(公告)号：US08282913B2
公开(公告)日：2012-10-09
申请号：US12055746
申请日：2008-03-26
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US08287847B2
公开(公告)日：2012-10-16
申请号：US12055765
申请日：2008-03-26
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US20110033505A1
公开(公告)日：2011-02-10
申请号：US12857264
申请日：2010-08-16
申请人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
IPC分类号： A61K9/00 , A61K31/663 , A61K31/662 , A61K31/185 , A61K31/194 , A61K31/19 , A61P9/12 , A61P7/10
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20080233073A1
公开(公告)日：2008-09-25
申请号：US12055765
申请日：2008-03-26
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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15.发明申请INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS 审中-公开具有C4-酸性取代基的单一化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US20090318492A1
公开(公告)日：2009-12-24
申请号：US12092380
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/437 , A61K31/40 , C07D471/02 , C07D209/04
CPC分类号： C07D209/32
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。
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16.发明授权Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors 有权多价吲哚化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US07666898B2
公开(公告)日：2010-02-23
申请号：US11593177
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/18 , C07D471/04 , C07D487/04
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。
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17.发明申请INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS 审中-公开具有C4酰胺取代基的单一化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US20090306171A1
公开(公告)日：2009-12-10
申请号：US12092388
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/404 , C07D209/20
CPC分类号： C07D209/22
摘要： Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R4 being a moiety represented by formula (C4-II-C), R3 being a moiety represented by formula (C3-I or C3-II).
摘要翻译： 公开了根据式（I）或（II）的任选具有其它杂原子的吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。 式（I），式（II）。 R4是由式（C4-II-C）表示的部分，R3是由式（C3-I或C3-II）表示的部分。
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18.发明申请公开(公告)号：US20090239896A1
公开(公告)日：2009-09-24
申请号：US12092385
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Tony Kwok-Kong Mong , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Tony Kwok-Kong Mong , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert FIG. 6c] in which at least one of CR4, CR5, CR6 and CR7 is replaced by N, and the groups R1-R7 are defined as in claim 1.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。 这些化合物包括下式的氮杂吲哚[ 6c]，其中CR4，CR5，CR6和CR7中的至少一个被N替代，基团R1-R7如权利要求1中所定义。
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公开(公告)号：US20100111891A1
公开(公告)日：2010-05-06
申请号：US12545810
申请日：2009-08-22
申请人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
发明人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
CPC分类号： A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要： The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及线性多元醇和包含氟基团和酸基团的交联阳离子交换聚合物的盐的组合物。 这些组合物可用于结合胃肠道中的钾。
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20.发明授权Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom 有权制备具有交联壳和由其产生的核 - 壳复合材料的核 - 壳复合材料的方法公开(公告)号：US08586097B2
公开(公告)日：2013-11-19
申请号：US12088611
申请日：2006-10-02
申请人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
发明人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
CPC分类号： A61K31/795 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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