公开(公告)号：US20130022570A1

公开(公告)日：2013-01-24

申请号：US13581049

申请日：2011-02-24

申请人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Quaker ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

发明人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Quaker ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

IPC分类号： C08F226/02 ,  A61P3/06 ,  A61K31/785

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08F20/52 ,  C08F22/385 ,  C08F222/385 ,  C08F226/02 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

公开(公告)号：US06833276B2

公开(公告)日：2004-12-21

申请号：US09911683

申请日：2001-07-24

申请人： Gerrit Klaerner ,  Ralph B. Nielsen ,  Paul Mansky ,  Didier Benoit ,  Dominique Charmot ,  Bernd Jandeleit ,  Laura T. Mazzola

发明人： Gerrit Klaerner ,  Ralph B. Nielsen ,  Paul Mansky ,  Didier Benoit ,  Dominique Charmot ,  Bernd Jandeleit ,  Laura T. Mazzola

IPC分类号： G01N33545

CPC分类号： G01N33/54353 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/44747 ,  Y10T428/8305 ,  Y10T436/10

摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

摘要翻译： 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合 探针。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

公开(公告)号：US06668230B2

公开(公告)日：2003-12-23

申请号：US10315519

申请日：2002-12-10

申请人： Paul Mansky ,  James Bennett

发明人： Paul Mansky ,  James Bennett

IPC分类号： G01N3100

CPC分类号： G01N25/005 ,  B01J19/0046 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  G01N25/18 ,  G01N27/72

摘要： A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for sending electrical signals to and receiving electrical signals from the sensor array; an apparatus for making electrical contact to the sensors in the standardized array format; an apparatus for routing signals between one or more selected sensors and the electronic test and measurement apparatus and a computer including a computer readable having a computer program recorded therein for controlling the operator of the apparatus. The sensor array is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. The interconnection apparatus and sensor array and contact pad allow measurement of many different material properties by using substrates carrying different sensor types, with only minor modifications if any to the electronic test and measurement apparatus and test procedures. By using a sensor array that is separate from the electronic apparatus, and by including standardized contacting and signal routing apparatuses, the apparatus creates a modular “plug-and-play” system that eliminates the need for multiple materials characterization machines, and eliminates the need for application-specific active circuitry within the sensor arrays themselves. Further, the modular sensor array system can characterize large numbers of material samples rapidly, on the order of at least 50 samples per hour, reducing the time needed for screening of materials libraries.

摘要翻译： 模块化材料表征装置包括设置在基板上的传感器阵列，具有标准化的阵列和接触垫格式; 电子测试和测量装置，用于向传感器阵列发送电信号并接收电信号; 用于以标准阵列格式与传感器电接触的装置; 用于在一个或多个选择的传感器和电子测试和测量装置之间路由信号的装置和包括计算机可读的计算机，其中记录有计算机程序以控制装置的操作者。 传感器阵列优选地以用于组合化学应用中的标准化格式布置，用于将样品材料快速沉积在传感器阵列上。 互连装置和传感器阵列和接触垫允许通过使用携带不同传感器类型的基板来测量许多不同的材料性质，只要对电子测试和测量装置和测试程序进行微小的修改即可。 通过使用与电子设备分离的传感器阵列，并且通过包括标准化的接触和信号路由设备，该设备创建了模块化的“即插即用”系统，其消除了对多种材料表征机器的需要，并且消除了需要 用于传感器阵列本身内的特定于应用的有源电路。 此外，模块化传感器阵列系统可以快速表征大量材料样品，每小时至少50个样品量级，减少了材料库筛选所需的时间。

公开(公告)号：US06535824B1

公开(公告)日：2003-03-18

申请号：US09458398

申请日：1999-12-10

申请人： Paul Mansky ,  James Bennett

发明人： Paul Mansky ,  James Bennett

IPC分类号： G01N3100

CPC分类号： G01N25/005 ,  B01J19/0046 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  G01N25/18 ,  G01N27/72

摘要： A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for sending electrical signals to and receiving electrical signals from the sensor array; an apparatus for making electrical contact to the sensors in the standardized array format; an apparatus for routing signals between one or more selected sensors and the electronic test and measurement apparatus and a computer including a computer readable having a computer program recorded therein for controlling the operator of the apparatus. The sensor array is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. The interconnection apparatus and sensor array and contact pad allow measurement of many different material properties by using substrates carrying different sensor types, with only minor modifications if any to the electronic test and measurement apparatus and test procedures. By using a sensor array that is separate from the electronic apparatus, and by including standardized contacting and signal routing apparatuses, the apparatus creates a modular “plug-and-play” system that eliminates the need for multiple materials characterization machines, and eliminates the need for application-specific active circuitry within the sensor arrays themselves. Further, the modular sensor array system can characterize large numbers of material samples rapidly, on the order of at least 50 samples per hour, reducing the time needed for screening of materials libraries.

公开(公告)号：US20140356316A1

公开(公告)日：2014-12-04

申请号：US13581148

申请日：2011-02-24

申请人： Eric Connor ,  Kalpesh Biyani ,  Scott Hecker ,  Inez Lees ,  Grace Huynh ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Xinnan Zhang

发明人： Eric Connor ,  Kalpesh Biyani ,  Scott Hecker ,  Inez Lees ,  Grace Huynh ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Xinnan Zhang

IPC分类号： A61K31/785 ,  C08G73/02

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08G73/02 ,  C08G73/0206 ,  A61K2300/00

摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

摘要翻译： 本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

公开(公告)号：US08617609B2

公开(公告)日：2013-12-31

申请号：US12088625

申请日：2006-10-02

申请人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen

发明人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen

IPC分类号： A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/5026 ,  A61K31/74 ,  A61K31/75 ,  A61K31/785 ,  A61K33/06

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

公开(公告)号：US20110236340A1

公开(公告)日：2011-09-29

申请号：US13060207

申请日：2009-08-22

申请人： Paul Mansky ,  Detlef Albrecht ,  Michael Burdick ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Sherin Halfon ,  I-Zu Huang ,  Mingjun Liu ,  Ramakrishnan Chidambaram ,  Jonathan Mills ,  Werner Strüver

发明人： Paul Mansky ,  Detlef Albrecht ,  Michael Burdick ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Sherin Halfon ,  I-Zu Huang ,  Mingjun Liu ,  Ramakrishnan Chidambaram ,  Jonathan Mills ,  Werner Strüver

IPC分类号： A61K31/78 ,  A61P3/02 ,  A61P13/12 ,  A61P9/10

CPC分类号： A61K31/78 ,  A61K9/14 ,  A61K31/7004 ,  A61K47/26 ,  B01J39/20 ,  C08F212/36 ,  C08F220/22

摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.

摘要翻译： 本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线性多元醇的组合物和这种聚合物的盐。 还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。 这些聚合物和组合物可用于结合胃肠道中的钾。

公开(公告)号：US20100104527A1

公开(公告)日：2010-04-29

申请号：US12545809

申请日：2009-08-22

申请人： Paul Mansky ,  Detlef Albrecht ,  Michael Burdick ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Sherin Halfon ,  I-Zu Huang ,  Mingjun Liu ,  Werner Strüver

发明人： Paul Mansky ,  Detlef Albrecht ,  Michael Burdick ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Sherin Halfon ,  I-Zu Huang ,  Mingjun Liu ,  Werner Strüver

IPC分类号： A61K31/74 ,  A61P1/00

CPC分类号： A61K31/78 ,  A61K31/74

摘要： The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.

摘要翻译： 本发明涉及通过施用具有有益物理性质的交联阳离子交换聚合物的药物组合物来除去钾或治疗高钾血症的方法，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态， 和/或溶胀比。

公开(公告)号：US20090186093A1

公开(公告)日：2009-07-23

申请号：US12088611

申请日：2006-10-02

申请人： Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Paul Mansky ,  Mingjun Liu

发明人： Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Paul Mansky ,  Mingjun Liu

IPC分类号： A61K9/16

CPC分类号： A61K31/795 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5042

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

公开(公告)号：US20050158879A1

公开(公告)日：2005-07-21

申请号：US11012416

申请日：2004-12-15

申请人： Gerrit Klaerner ,  Ralph Nielsen ,  Paul Mansky ,  Didier Benoit ,  Dominique Charmot ,  Bernd Jandeleit ,  Laura Mazzola

发明人： Gerrit Klaerner ,  Ralph Nielsen ,  Paul Mansky ,  Didier Benoit ,  Dominique Charmot ,  Bernd Jandeleit ,  Laura Mazzola

IPC分类号： C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C12Q1/68

CPC分类号： G01N33/54353 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/44747 ,  Y10T428/8305 ,  Y10T436/10

摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

摘要翻译： 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合 探针。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。