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1.发明授权Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors 有权多价吲哚化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US07666898B2
公开(公告)日：2010-02-23
申请号：US11593177
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/18 , C07D471/04 , C07D487/04
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。
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2.发明申请Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors 有权多价吲哚化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US20070135385A1
公开(公告)日：2007-06-14
申请号：US11593177
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/675 , A61K31/404 , C07D209/36
CPC分类号： C07D209/18 , C07D471/04 , C07D487/04
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。
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3.发明申请Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors 审中-公开磷脂酶抑制剂，包括多价磷脂酶抑制剂及其用途，包括作为内腔定位的磷脂酶抑制剂公开(公告)号：US20070135383A1
公开(公告)日：2007-06-14
申请号：US11593176
申请日：2006-11-03
申请人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/685 , A61K31/66 , A61K31/503 , A61K31/4745 , A61K31/405 , A61K31/365
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/0095 , A61K31/41 , A61K31/66 , A61K47/10 , A61K47/20 , A61K47/55 , A61K47/58
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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