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公开(公告)号：US08409561B2
公开(公告)日：2013-04-02
申请号：US12857264
申请日：2010-08-16
申请人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US07854924B2
公开(公告)日：2010-12-21
申请号：US10814527
申请日：2004-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US07488495B2
公开(公告)日：2009-02-10
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US07776319B2
公开(公告)日：2010-08-17
申请号：US11095760
申请日：2005-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US07556799B2
公开(公告)日：2009-07-07
申请号：US11096209
申请日：2005-03-30
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US20110033505A1
公开(公告)日：2011-02-10
申请号：US12857264
申请日：2010-08-16
申请人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
IPC分类号： A61K9/00 , A61K31/663 , A61K31/662 , A61K31/185 , A61K31/194 , A61K31/19 , A61P9/12 , A61P7/10
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20080241093A1
公开(公告)日：2008-10-02
申请号：US12055746
申请日：2008-03-26
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US07429394B2
公开(公告)日：2008-09-30
申请号：US11095918
申请日：2005-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐失衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过量。
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公开(公告)号：US08445014B2
公开(公告)日：2013-05-21
申请号：US12238844
申请日：2008-09-26
申请人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/14
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20090148533A1
公开(公告)日：2009-06-11
申请号：US12238844
申请日：2008-09-26
申请人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/16 , A61K31/795 , A61K31/80 , A61K31/74 , A61P7/00
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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