公开(公告)号：US20160252533A1

公开(公告)日：2016-09-01

申请号：US15030790

申请日：2014-10-17

Applicant: DYAX CORP.

Inventor： Daniel J. Sexton ,  Burt Adelman ,  Andrew Nixon

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/564 ,  G01N2333/745 ,  G01N2333/8139 ,  G01N2800/065 ,  G01N2800/102 ,  G01N2800/52 ,  G01N2800/56

Abstract: Methods, kits and compositions for diagnosing and treating autoimmune diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.

Abstract translation: 用于诊断和治疗自身免疫疾病如风湿性关节炎，克罗恩病和溃疡性结肠炎的方法，试剂盒和组合物。

公开(公告)号：US10913802B2

公开(公告)日：2021-02-09

申请号：US15746048

申请日：2016-07-21

Applicant: Dyax Corp.

Inventor： Shauna Mason ,  Jon A. Kenniston ,  Andrew Nixon ,  Daniel J. Sexton ,  Stephen R. Comeau ,  Burt Adelman

IPC: C07K16/36 ,  A61K39/00 ,  A61P7/02 ,  A61P9/00 ,  A61P11/00

Abstract: Disclosed herein are anti-Factor XIIa antibodies and methods of using such for treating diseases associated with Factor XII, including diseases associated with contact system activation, plasma prekallikrein signaling (e.g., hereditary angioedema), and ocular diseases.

公开(公告)号：US20190120862A1

公开(公告)日：2019-04-25

申请号：US16131781

申请日：2018-09-14

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Burt Adelman ,  Andrew Nixon

IPC: G01N33/86 ,  G01N33/564

Abstract: Methods, kits and compositions for diagnosing and treating autoimmue diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.

公开(公告)号：US20190002584A1

公开(公告)日：2019-01-03

申请号：US15746048

申请日：2016-07-21

Applicant: Dyax Corp.

Inventor： Shauna Mason ,  Jon A. Kenniston ,  Andrew Nixon ,  Daniel J. Sexton ,  Stephen R. Comeau ,  Burt Adelman

IPC: C07K16/36

Abstract: Disclosed herein are anti-Factor Xlla antibodies and methods of using such for treating diseases associated with Factor XII, including diseases associated with contact system activation, plasma prekallikrein signaling (e.g., hereditary angioedema), and ocular diseases.

公开(公告)号：US20160252527A1

公开(公告)日：2016-09-01

申请号：US15030811

申请日：2014-10-17

Applicant: DYAX CORP.

Inventor： Daniel J. Sexton ,  Ryan Faucette ,  Jon A. Kenniston ,  Gregory P. Conley ,  Andrew Nixon ,  Christopher TenHoor ,  Burt Adelman

IPC: G01N33/68 ,  C07K16/40 ,  C12Q1/37

CPC classification number: G01N33/6893 ,  A61K2039/505 ,  C07K16/36 ,  C07K16/40 ,  C07K2317/76 ,  C12Q1/37 ,  C12Q1/56 ,  C12Y304/21034 ,  C12Y304/21038 ,  G01N2333/4713 ,  G01N2333/96455 ,  G01N2333/96458 ,  G01N2500/02 ,  G01N2500/20 ,  G01N2800/224 ,  G01N2800/50 ,  G01N2800/52

Abstract: Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

Abstract translation: 用于确定血浆激肽释放酶（pKal）系统的激活水平的方法和测定及其用于评估pKal系统上pKal调节剂活性的用途。