公开(公告)号：US20140316143A1

公开(公告)日：2014-10-23

申请号：US14253976

申请日：2014-04-16

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Datong Tang ,  Guoyou Xu ,  Xiaowen Peng ,  Lu Ying ,  Ce Wang ,  Hui Cao ,  Jiang Long ,  In Jong Kim ,  Guoqiang Wang ,  Yao-Ling Qiu ,  Yat Sun Or

IPC: C07D403/14

CPC classification number: C07D403/14

Abstract: The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatitis C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):

Abstract translation: 本发明涉及制备新型苯并咪唑衍生物的方法和中间体，特别是在丙型肝炎病毒NS5A抑制剂的合成中。 特别地，本发明涉及制备式（I-a）化合物的方法和中间体：

公开(公告)号：US20140135485A1

公开(公告)日：2014-05-15

申请号：US14047424

申请日：2013-10-07

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Dequiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina V. Busuek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC: C07H17/08

CPC classification number: C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract translation: 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20140073797A1

公开(公告)日：2014-03-13

申请号：US14019604

申请日：2013-09-06

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Guoyou Xu ,  Datong Tang ,  In Jong Kim ,  Ly Tam Phan ,  Yat Sun Or ,  Zhe Wang

IPC: C07D417/04

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D493/08

Abstract: The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (X-c):

Abstract translation: 本发明涉及制备2-氟6-11双环红霉素衍生物的方法和中间体。 特别地，本发明涉及制备式（X-c）化合物的方法和中间体：