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![PROCESSES FOR THE PREPARATION OF 5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES](/abs-image/US/2014/07/03/US20140187793A1/abs.jpg.150x150.jpg)
1.发明申请PROCESSES FOR THE PREPARATION OF 5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES 有权制备5-亚苄基[2.4]庚-6-烯羧酸及其衍生物的方法公开(公告)号：US20140187793A1
公开(公告)日：2014-07-03
申请号：US14082406
申请日：2013-11-18
Applicant: ENANTA PHARMACEUTICALS, INC.
Inventor： Yao-Ling Qiu , Xiaowen Peng , In Jong Kim , Hui Cao , Datong Tang , Yat Sun Or , Guoqiang Wang , Guoyou Xu
IPC: C07D209/54
CPC classification number: C07D209/54
Abstract: The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):
Abstract translation: 本发明一般涉及一种制备5-氮杂螺[2.4]庚烷-6-羧酸及其衍生物的改进方法，其在合成生物活性分子中是有用的中间体，特别是在合成肝素C病毒NS5A抑制剂 。 特别地，本发明涉及制备式（Ia），（Ib）和（Ic）化合物的方法和中间体：
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公开(公告)号：US10947264B2
公开(公告)日：2021-03-16
申请号：US16784296
申请日：2020-02-07
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yong He , Peng Dai , Guoyou Xu , Bin Wang , Jiang Long , Yat Sun Or
Abstract: The present invention relates to compounds of Formulas 3-6, where R4 PG1 and PG2 are defined as disclosed herein. These compounds are useful as intermediates in processes for preparing a compound of Formula I: where R1 is defined as disclosed herein.
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公开(公告)号：US20180148469A1
公开(公告)日：2018-05-31
申请号：US15826233
申请日：2017-11-29
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yong He , Peng Dai , Guoyou Xu , Bin Wang , Jiang Long , Yat Sun Or
Abstract: The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use.The present invention relates to a process for the preparation of a compound (II) and its salts and derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of FXR and TGR5 modulators. The present invention also relates to a process for the preparation of a compound (III) and its diethylamine salt.
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公开(公告)号：US10584145B2
公开(公告)日：2020-03-10
申请号：US15826233
申请日：2017-11-29
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yong He , Peng Dai , Guoyou Xu , Bin Wang , Jiang Long , Yat Sun Or
Abstract: The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use. The present invention relates to a process for the preparation of a compound (II) and its salts and derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of FXR and TGR5 modulators. The present invention also relates to a process for the preparation of a compound (III) and its diethylamine salt.
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![Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives](/abs-image/US/2015/01/06/US08927739B2/abs.jpg.150x150.jpg)
5.发明授权Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives 有权制备5-氮杂螺[2.4]庚烷-6-羧酸及其衍生物的方法公开(公告)号：US08927739B2
公开(公告)日：2015-01-06
申请号：US14082406
申请日：2013-11-18
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Yao-Ling Qiu , Xiaowen Peng , In Jong Kim , Hui Cao , Datong Tang , Yat Sun Or , Guoqiang Wang , Guoyou Xu
IPC: C07D209/54
CPC classification number: C07D209/54
Abstract: The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):
Abstract translation: 本发明一般涉及一种制备5-氮杂螺[2.4]庚烷-6-羧酸及其衍生物的改进方法，其在合成生物活性分子中是有用的中间体，特别是在合成肝素C病毒NS5A抑制剂 。 特别地，本发明涉及制备式（Ia），（Ib）和（Ic）化合物的方法和中间体：
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Patent Agency Ranking
公开(公告)号：US20170240585A1
公开(公告)日：2017-08-24
申请号：US15439358
申请日：2017-02-22
Applicant: ENANTA PHARMACEUTICALS, INC.
Inventor： Guoqiang Wang , Yat Sun Or , Jiang Long , Guoyou Xu , Peng Dai , Ruichao Shen , Xuechao Xing , Jing He
CPC classification number: C07J41/0055 , C07B59/007 , C07B2200/05 , C07J9/005 , C07J17/00 , C07J43/003 , C07J51/00
Abstract: The present invention provides compounds of Formula (I) or Formula (II): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR and/or TGR5.
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7.发明授权Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives 有权2-氟6-11双环红霉素衍生物的制备方法公开(公告)号：US09242974B2
公开(公告)日：2016-01-26
申请号：US14019604
申请日：2013-09-06
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoyou Xu , Datong Tang , In Jong Kim , Ly Tam Phan , Yat Sun Or , Zhe Wang
IPC: C07D417/04 , C07D417/14 , C07D493/08
CPC classification number: C07D417/04 , C07D417/14 , C07D493/08
Abstract: The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (X-c):
Abstract translation: 本发明涉及制备2-氟6-11双环红霉素衍生物的方法和中间体。 特别地，本发明涉及制备式（X-c）化合物的方法和中间体：
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公开(公告)号：US20200247839A1
公开(公告)日：2020-08-06
申请号：US16784296
申请日：2020-02-07
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yong He , Peng Dai , Guoyou Xu , Bin Wang , Jiang Long , Yat Sun Or
Abstract: The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, and intermediates of use in said processes.
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公开(公告)号：US10364267B2
公开(公告)日：2019-07-30
申请号：US15439358
申请日：2017-02-22
Applicant: ENANTA PHARMACEUTICALS, INC.
Inventor： Guoqiang Wang , Yat Sun Or , Jiang Long , Guoyou Xu , Peng Dai , Ruichao Shen , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula (I) or Formula (II): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR and/or TGR5.
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公开(公告)号：US08921573B2
公开(公告)日：2014-12-30
申请号：US14253976
申请日：2014-04-16
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Datong Tang , Guoyou Xu , Xiaowen Peng , Lu Ying , Ce Wang , Hui Cao , Jiang Long , In Jong Kim , Guoqiang Wang , Yao-Ling Qiu , Yat Sun Or
IPC: C07D403/14
CPC classification number: C07D403/14
Abstract: The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatitis C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):
Abstract translation: 本发明涉及制备新型苯并咪唑衍生物的方法和中间体，特别是在丙型肝炎病毒NS5A抑制剂的合成中。 特别地，本发明涉及制备式（I-a）化合物的方法和中间体：
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