公开(公告)号：US07195868B2

公开(公告)日：2007-03-27

申请号：US10125159

申请日：2002-04-18

申请人： Natalia Iartchouk ,  Mark D. Ayers ,  Jeffrey L. Brown

发明人： Natalia Iartchouk ,  Mark D. Ayers ,  Jeffrey L. Brown

IPC分类号： C12Q1/68

CPC分类号： A61K31/337 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57449 ,  G01N2800/52

摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent.

摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明具有许多“灵敏度标记”。 这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。 本发明还具有许多“电阻标记”。 这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。

公开(公告)号：USD399329S

公开(公告)日：1998-10-06

申请号：US65100

申请日：1997-01-21

申请人： Frederick A. Compton ,  Jeffrey L. Brown

设计人： Frederick A. Compton ,  Jeffrey L. Brown

公开(公告)号：US4138153A

公开(公告)日：1979-02-06

申请号：US832496

申请日：1977-09-12

申请人： Jeffrey L. Brown

发明人： Jeffrey L. Brown

IPC分类号： E01H1/12 ,  A01K29/00 ,  A47L13/52

CPC分类号： E01H1/1206 ,  E01H2001/126 ,  E01H2001/1293

摘要： A sanitary self-contained fecal waste container which is especially useful for cleaning up after pet animals. The unit contains a collapsible frame to which is secured a pouch, a portion of which is folded backward upon itself. The bottom portion of the frame has a forwardly extending shovel portion with a serrated edge and a rearwardly extending barrier member. Extending upwardly from the bottom portion are side and top portions separated by folds. Thence extending upwardly from the folds at the opposie ends of the top portions, are handled grip portions forming a handle.The frame is extended, the barrier member is removed and aids in putting feces, for example on the street or sidewalk, into the pouch. The folded over portion is pulled forward to enclose the frame, shovel portion and the barrier which is placed in the pouch. The pouch may then be secured by a tie, and disposed of as desired.

摘要翻译： 一种卫生独立的粪便废物容器，特别适用于宠物动物之后的清理。 该单元包含一个可折叠的框架，固定一个小袋，其一部分自身向后折叠。 框架的底部具有向前延伸的挖铲部分，其具有锯齿形边缘和向后延伸的阻挡件。 从底部向上延伸的是由褶皱分开的侧面和顶部。 然后从顶部的对置端部的折叠部向上延伸，被处理成形成把手的把持部。