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公开(公告)号：US20210283396A1
公开(公告)日：2021-09-16
申请号：US17315883
申请日：2021-05-10
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.
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12.发明申请公开(公告)号：US20200230408A1
公开(公告)日：2020-07-23
申请号：US16838953
申请日：2020-04-02
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Bruce J. Simon , Peter Staats , Thomas Errico
摘要： Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient. The systems and methods of the present invention reduce the expression of inflammatory mediators that are elevated in ARDS and other inflammatory or allergic disorders, thereby ameliorating the overactivity of the immune reaction in patient's suffering from certain disorders, such as the coronavirus. This therapy may include a feedback mechanism to provide potent anti-inflammatory benefits without the negative side effects of conventional immune suppression techniques and drugs, such as steroids and other nebulized drugs.
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公开(公告)号：US20200078589A1
公开(公告)日：2020-03-12
申请号：US16662295
申请日：2019-10-24
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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14.发明申请公开(公告)号：US20200038655A1
公开(公告)日：2020-02-06
申请号：US16597188
申请日：2019-10-09
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
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15.发明申请公开(公告)号：US20190336764A1
公开(公告)日：2019-11-07
申请号：US16511953
申请日：2019-07-15
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
IPC分类号： A61N1/36 , A61B5/00 , A61N1/04 , A61B5/0488
摘要： Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
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公开(公告)号：US20190275327A1
公开(公告)日：2019-09-12
申请号：US16356639
申请日：2019-03-18
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
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公开(公告)号：US20190209841A1
公开(公告)日：2019-07-11
申请号：US16355306
申请日：2019-03-15
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
CPC分类号： A61N1/36021 , A61B5/0071 , A61B5/066 , A61B5/6898 , A61B5/7425 , A61N1/0456 , A61N1/36014 , A61N1/36025 , A61N1/37217 , A61N1/3756 , A61N1/3787 , H04M1/21 , H04M2250/12
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
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公开(公告)号：US11511109B2
公开(公告)日：2022-11-29
申请号：US16278945
申请日：2019-02-19
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
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公开(公告)号：US20220323745A1
公开(公告)日：2022-10-13
申请号：US17731393
申请日：2022-04-28
申请人： ELECTROCORE, INC
发明人： Peter Staats , Bruce J. Simon , Joseph P. Errico
摘要： Systems, devices and methods are provided for delivering electrical impulses to the vagus nerve to inhibit the reduction of telomere lengths in cellular DNA, thereby potentially increasing an individual's longevity and/or healthspan. A method comprises positioning a contact surface of a device in contact with an outer skin surface of a patient. An electrical impulse is applied transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol. The stimulation protocol includes at least two doses administered each day for a plurality of day. The doses each have a duration of about 60 seconds to about 5 minutes, preferably about 90 seconds to 3 minutes. The electrical impulse and the stimulation protocol are sufficient to modulate the vagus nerve such that such that the rate of telomere shortening in the patient's cellular DNA is reduced.
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公开(公告)号：US20220233845A1
公开(公告)日：2022-07-28
申请号：US17713832
申请日：2022-04-05
申请人： electroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds
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