公开(公告)号：US20120058150A1

公开(公告)日：2012-03-08

申请号：US13041960

申请日：2011-03-07

申请人： David A. Prawel ,  Susan P. James ,  Ketul C. Popat

发明人： David A. Prawel ,  Susan P. James ,  Ketul C. Popat

IPC分类号： A61K9/00 ,  A61K31/685 ,  A61P31/04 ,  A61M5/142 ,  A61P7/02 ,  B05D1/02 ,  B05D7/00 ,  A61K31/7036 ,  A61P35/00

CPC分类号： A61K31/685 ,  A61K31/7036 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/62 ,  A61L2420/02 ,  B05D1/04

摘要： Methods are provided for administering a phospholipid composition to a subject, comprising coating a medical device with at least one layer of a phospholipid composition, wherein the coating is achieved by electrospraying the device with the composition, and wherein the composition is carrying or can carry at least one therapeutic agent.

摘要翻译： 提供了用于向受试者施用磷脂组合物的方法，包括用至少一层磷脂组合物涂覆医疗装置，其中所述涂层通过用所述组合物电喷雾所述装置来实现，并且其中所述组合物携带或可携带 至少一种治疗剂。

公开(公告)号：US07692000B2

公开(公告)日：2010-04-06

申请号：US10571662

申请日：2004-09-20

申请人： Susan P. James ,  Min Zhang

发明人： Susan P. James ,  Min Zhang

IPC分类号： C08B37/00

CPC分类号： C08B37/0072

摘要： A series of novel, melt- or mold-processable HA esters with varying aliphatic chain lengths are synthesized from silyl HA-quaternary (quat.) ammonium salt complex (preferably silyl HA-CTA, a silylated HA complex with cetyltrimethyl ammonium salt). Introduction of aliphatic acyl groups, preferably acid chlorides, to disrupt the strong HA intermolecular bonding, is done via acylation. Acylation takes place at the oxygen of the trimethylsilyloxy group —O—Si(CH3)3 in the silyl HA-CTA by removal of trimethylsilyl groups therefrom. Optionally, crosslinking may be performed during the shaping/molding of the HA esters into a structure/device, or thereafter, if at all. Native HA can then be regenerated/recovered by saponification hydrolysis, removing acyl groups, —CH3(CH2)10CO, and the cetyltrimethyl ammonium salt groups, -CTA, from HA ester. The structure/device of a preselected shape (e.g., porous or solid, bulk structure or fibers) may become a component of an assembly, a product that is further processed, integrated into another component (e.g., laminated, adhered, assembled, further shaped, chemically-intermixed/intermingled), and so on.

摘要翻译： 从甲硅烷基HA-季（铵）铵盐络合物（优选甲硅烷基HA-CTA，甲硅烷基化的HA配合物与十六烷基三甲基铵盐）合成一系列具有不同脂肪链长度的新型，熔融或可模塑加工的HA酯。 引入脂族酰基，优选酰氯，以破坏强HA分子间键，是通过酰化进行的。 通过从其中除去三甲基甲硅烷基，在甲硅烷基HA-CTA中的三甲基甲硅烷氧基-O-Si（CH 3）3的氧上进行酰化。 任选地，可以在将HA酯成型/成型成结构/装置期间或之后（如果有的话）进行交联。 然后可以通过皂化水解再生/回收天然HA，从HA酯除去酰基，-CH 3（CH 2）10 CO和十六烷基三甲基铵盐基团-CTA。 预选形状（例如，多孔或固体，本体结构或纤维）的结构/装置可以成为组件的组件，进一步加工的产品集成到另一部件中（例如，层压，粘合，组装，进一步成形 ，化学混合/混合）等。

公开(公告)号：US5480450A

公开(公告)日：1996-01-02

申请号：US16697

申请日：1993-02-11

申请人： Susan P. James ,  Daphne Karydas ,  Frederick M. McGarry ,  William H. Harris

发明人： Susan P. James ,  Daphne Karydas ,  Frederick M. McGarry ,  William H. Harris

IPC分类号： A61B17/68 ,  A61F2/00 ,  A61F2/30 ,  A61F2/36 ,  A61F2/46

CPC分类号： A61B17/8808 ,  A61B17/68 ,  A61F2/30742 ,  A61F2/367 ,  A61F2002/30113 ,  A61F2002/30153 ,  A61F2002/30729 ,  A61F2002/3096 ,  A61F2002/30975 ,  A61F2002/3631 ,  A61F2230/0006 ,  A61F2230/0019

摘要： A diaphragm for minimizing interfacial porosity during the insertion of a femoral component into the cavity in the medullary canal of a femur. By providing a seal around the outer medial, lateral, anterior and posterior surfaces of the component during insertion through the diaphragm, the introduction of pores into the cement during the insertion process is minimized and flow of cement out of the cavity is resisted. The diaphragm may be formed of at least one rigid layer and a resilient layer, the resilient layer providing the desired seal. In another embodiment, the diaphragm may be formed of two stacked discs which permit expansion in two orthogonal directions and which have holes which include seals on the inner surface thereof to provide a seal between the diaphragm and the outer surfaces of the component. In the method of the present invention, a diaphragm is placed over the opening of the cavity to resist the flow of cement out of the cavity to pressurize the cement during insertion of the component, as well as to provide a seal between the diaphragm and the component to resist the introduction of air into the cement. After insertion, the diaphragm is cut or otherwise separated to allow removal thereof.

摘要翻译： 用于在将股骨部件插入股骨髓腔中的空腔中最小化界面孔隙的隔膜。 通过在插入通过隔膜的过程中在组件的外侧中间，外侧，前后表面附近提供密封，在插入过程中将孔引入到水泥中被最小化，从而阻止了水泥流出空腔。 隔膜可以由至少一个刚性层和弹性层形成，弹性层提供期望的密封。 在另一个实施例中，隔膜可以由允许在两个正交方向上膨胀并且具有在其内表面上包括密封件的孔的两个堆叠盘形成，以在隔膜和部件的外表面之间提供密封。 在本发明的方法中，将膜片放置在空腔的开口上方以抵抗水泥浆流出空腔，以在插入部件期间对水泥进行加压，以及在隔膜和隔膜之间提供密封 组件以抵抗将空气引入水泥中。 插入后，隔膜被切割或以其他方式分离以允许其移除。