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公开(公告)号：US07956043B2
公开(公告)日：2011-06-07
申请号：US10735592
申请日：2003-12-11
申请人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
CPC分类号： C12N15/117 , A61K2039/55561 , C07H21/04 , C12N2310/315
摘要： The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类含有5'5GG基序或在5'端或附近的可用于刺激免疫应答的CpG免疫刺激性寡核苷酸。
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公开(公告)号：US20050239733A1
公开(公告)日：2005-10-27
申请号：US10977560
申请日：2004-10-29
申请人： Marion Jurk , Jorg Vollmer , Arthur Krieg , Eugen Uhlmann
发明人： Marion Jurk , Jorg Vollmer , Arthur Krieg , Eugen Uhlmann
IPC分类号： A61K48/00 , C07H21/04 , C12N15/117
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , C12N2310/336 , C12N2310/3521
摘要： Novel oligonucleotides having immune inhibitory effects, and methods for their use, are provided. The inhibitory oligonucleotides include those that specifically inhibit certain Toll-like receptors, including TLR7, TLR8, and TLR9. Certain of the immunoinhibitory oligonucleotides inhibit a combination of TLRs selected from TLR7, TLR8, and TLR9. Inhibitors of TLR9 are characterized by a 5′ CC dinucleotide appropriately spaced upstream of a G-rich oligomer. Inhibitors of TLR8 include specific simple dinucleotides and oligonucleotides ending at their 3′ termini with the specific dinucleotides. TLR7 inhibitors include oligonucleotides having a phosphorothioate backbone. Also provided are combinations and conjugates involving the inhibitory oligonucleotides of the invention and other agents, where the other agents include TLR agonists and antigens. Compositions of the invention can be used to shape an immune response, reduce unwanted specific TLR-mediated immunostimulation, and to treat conditions including allergy, asthma, infection, and cancer.
摘要翻译： 提供了具有免疫抑制作用的新型寡核苷酸及其使用方法。 抑制性寡核苷酸包括特异性抑制某些Toll样受体的那些，包括TLR7，TLR8和TLR9。 某些免疫抑制性寡核苷酸抑制了选自TLR7，TLR8和TLR9的TLR的组合。 TLR9的抑制剂的特征在于在富G寡聚体上游适当间隔5'CC二核苷酸。 TLR8的抑制剂包括特异性简单二核苷酸和寡核苷酸终止于其3'末端与特异性二核苷酸。 TLR7抑制剂包括具有硫代磷酸酯骨架的寡核苷酸。 还提供了涉及本发明的抑制性寡核苷酸和其它试剂的组合和缀合物，其中其它试剂包括TLR激动剂和抗原。 可以使用本发明的组合物来形成免疫应答，减少不需要的特异性TLR介导的免疫刺激，并且治疗包括变态反应，哮喘，感染和癌症的病症。
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13.发明申请Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification 审中-公开通过核苷酸修饰调节短干扰核糖核酸（Sirna）的免疫刺激性质公开(公告)号：US20090306177A1
公开(公告)日：2009-12-10
申请号：US11992073
申请日：2006-09-15
申请人： Eugen Uhlmann , Marion Jurk , Joerg Vollmer , Christian Schetter , Martin Weber , Ioanna Andreou , Stefan Pitsch
发明人： Eugen Uhlmann , Marion Jurk , Joerg Vollmer , Christian Schetter , Martin Weber , Ioanna Andreou , Stefan Pitsch
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/17 , C12N2310/352 , C12N2310/353 , C12N2320/50 , C12Y207/11024
摘要： Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2′ sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.
摘要翻译： 修饰双链短干扰核糖核酸（siRNA）以降低或消除其免疫刺激作用，而不显着影响其基因沉默效应。 修饰的siRNA包括一个或多个2'糖修饰物，并且任选地在有义链上包含核苷酸间键。 公开了含有修饰的siRNA的组合物和制备和使用经修饰的siRNA的方法。 可以合成新的和以前表征的siRNA以掺入根据本发明的修饰。
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公开(公告)号：US20070224210A1
公开(公告)日：2007-09-27
申请号：US11542845
申请日：2006-10-04
申请人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
发明人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
IPC分类号： A61K39/00
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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公开(公告)号：US20060188913A1
公开(公告)日：2006-08-24
申请号：US11368334
申请日：2006-03-03
申请人： Arthur Krieg , Christian Schetter , Robert Bratzler , Jorg Vollmer , Marion Jurk , Stefan Bauer
发明人： Arthur Krieg , Christian Schetter , Robert Bratzler , Jorg Vollmer , Marion Jurk , Stefan Bauer
CPC分类号： G01N33/6863 , A61K31/4745 , A61K31/522 , A61K31/56 , A61K39/39 , A61K39/395 , A61K2039/55511 , A61K2039/55561 , G01N2500/04 , A61K2300/00
摘要： The invention involves administration of an imidazoquinoline agent in combination with another therapeutic agent. The combination of drugs may be administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs. The combinations can be used to enhance ADCC, stimulate immune responses and/or patient and treat certain disorders.
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16.发明授权RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱公开(公告)号：US08466124B2
公开(公告)日：2013-06-18
申请号：US13494216
申请日：2012-06-12
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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公开(公告)号：US20120258140A1
公开(公告)日：2012-10-11
申请号：US13494216
申请日：2012-06-12
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K39/35 , A61P37/08 , A61K31/7105
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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18.发明申请RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES 有权诱导特异性免疫调节剂分析的定义的核苷酸连接物的RNA序列运动公开(公告)号：US20120121648A1
公开(公告)日：2012-05-17
申请号：US13360894
申请日：2012-01-30
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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公开(公告)号：US08227447B2
公开(公告)日：2012-07-24
申请号：US13360894
申请日：2012-01-30
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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20.发明授权RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱公开(公告)号：US08128944B2
公开(公告)日：2012-03-06
申请号：US12670697
申请日：2008-08-08
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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