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1.发明申请Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification 审中-公开通过核苷酸修饰调节短干扰核糖核酸（Sirna）的免疫刺激性质公开(公告)号：US20090306177A1
公开(公告)日：2009-12-10
申请号：US11992073
申请日：2006-09-15
申请人： Eugen Uhlmann , Marion Jurk , Joerg Vollmer , Christian Schetter , Martin Weber , Ioanna Andreou , Stefan Pitsch
发明人： Eugen Uhlmann , Marion Jurk , Joerg Vollmer , Christian Schetter , Martin Weber , Ioanna Andreou , Stefan Pitsch
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/17 , C12N2310/352 , C12N2310/353 , C12N2320/50 , C12Y207/11024
摘要： Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2′ sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.
摘要翻译： 修饰双链短干扰核糖核酸（siRNA）以降低或消除其免疫刺激作用，而不显着影响其基因沉默效应。 修饰的siRNA包括一个或多个2'糖修饰物，并且任选地在有义链上包含核苷酸间键。 公开了含有修饰的siRNA的组合物和制备和使用经修饰的siRNA的方法。 可以合成新的和以前表征的siRNA以掺入根据本发明的修饰。
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公开(公告)号：US20050059619A1
公开(公告)日：2005-03-17
申请号：US10644052
申请日：2003-08-19
申请人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
发明人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
IPC分类号： A61K31/70 , A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/117 , C12Q1/00 , C12Q1/68
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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公开(公告)号：US08283328B2
公开(公告)日：2012-10-09
申请号：US10644052
申请日：2003-08-19
申请人： Arthur M. Krieg , Grayson Lipford , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
发明人： Arthur M. Krieg , Grayson Lipford , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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4.发明申请Phosphate-Modified Oligonucleotide Analogs with Enhanced Immunostimulatory Activity 有权磷酸修饰的寡核苷酸类似物与增强的免疫刺激活性公开(公告)号：US20100261779A1
公开(公告)日：2010-10-14
申请号：US12600368
申请日：2008-05-15
申请人： Eugen Uhlmann , Marion Jurk
发明人： Eugen Uhlmann , Marion Jurk
IPC分类号： A61K31/7125 , A61P35/00 , A61P31/00 , A61P11/06 , A61P37/08
CPC分类号： C12N15/117 , A61K31/7125 , A61K45/06 , C12N2310/17 , C12N2310/311 , C12N2310/3125 , C12N2310/315 , Y02A50/463 , A61K2300/00
摘要： The invention relates to oligonucleotides including at least one backbone modification and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种骨架修饰和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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公开(公告)号：US20100189772A1
公开(公告)日：2010-07-29
申请号：US12443224
申请日：2007-09-27
申请人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
发明人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
CPC分类号： A61K31/7088 , A61K45/06 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/336 , C12N2310/351 , C12N2320/31 , A61K2300/00
摘要： The invention relates to methods and products for the treatment of viral infection using a combination of anti-viral agents and TLR ligands. The invention also relates to screening assays, associated products, kits, and in vitro methods.
摘要翻译： 本发明涉及使用抗病毒剂和TLR配体的组合治疗病毒感染的方法和产品。 本发明还涉及筛选测定，相关产品，试剂盒和体外方法。
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公开(公告)号：US20100144846A1
公开(公告)日：2010-06-10
申请号：US12447107
申请日：2007-10-26
申请人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
IPC分类号： A61K31/7088 , C07H21/02 , C07K2/00 , C07K14/00 , A61P35/00 , A61P37/08 , A61P31/12 , A61P11/00 , A61P37/02
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/317 , C12N2310/336 , C12N2310/3511 , C12N2310/3515 , C12N2310/3517
摘要： The invention relates to immunostimulatory RNA oligonucleotides (ORN). In particular the ORN have an immunostimulatory ORN motif directly or indirectly flanked by a 3′ poly G motif and optionally a 5′ poly-G motif. The invention also relates to methods including therapeutic methods and screening methods and related kits for use of the ORN.
摘要翻译： 本发明涉及免疫刺激RNA寡核苷酸（ORN）。 特别地，ORN具有直接或间接侧接于3'poly G基序和任选的5'poly-G基序的免疫刺激性ORN基序。 本发明还涉及包括用于ORN的治疗方法和筛选方法以及相关试剂盒的方法。
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公开(公告)号：US08304396B2
公开(公告)日：2012-11-06
申请号：US11542845
申请日：2006-10-04
申请人： Arthur M. Krieg , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson B. Lipford , Robert Rankin
发明人： Arthur M. Krieg , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson B. Lipford , Robert Rankin
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
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8.发明申请CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity 有权含有增强免疫刺激活性的疏水性T类似物的CpG寡核苷酸类似物公开(公告)号：US20100166780A1
公开(公告)日：2010-07-01
申请号：US12442295
申请日：2007-09-27
申请人： Harald Debelak , Eugen Uhlmann , Marion Jurk
发明人： Harald Debelak , Eugen Uhlmann , Marion Jurk
IPC分类号： A61K39/00 , C07H19/06 , C07H19/16 , C07H19/052 , C07H19/056 , A61K31/702 , A61P31/12
CPC分类号： C12N15/117 , C07H21/00 , C12N2310/17 , C12N2310/31 , C12N2310/315 , C12N2310/33 , C12N2310/332 , C12N2310/335
摘要： The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种亲脂性取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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公开(公告)号：US07956043B2
公开(公告)日：2011-06-07
申请号：US10735592
申请日：2003-12-11
申请人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
CPC分类号： C12N15/117 , A61K2039/55561 , C07H21/04 , C12N2310/315
摘要： The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类含有5'5GG基序或在5'端或附近的可用于刺激免疫应答的CpG免疫刺激性寡核苷酸。
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10.发明申请IMMUNE STIMULATORY OLIGONUCLEOTIDE ANALOGS CONTAINING MODIFIED SUGAR MOIETIES 有权含有改性糖酵母的免疫刺激寡核苷酸模拟物公开(公告)号：US20110098456A1
公开(公告)日：2011-04-28
申请号：US12681800
申请日：2008-09-09
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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