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公开(公告)号：US20240233859A9
公开(公告)日：2024-07-11
申请号：US18397262
申请日：2023-12-27
Applicant: FUJIFILM Corporation
Inventor： Takahiro TERAO , Masaya NAGASE
Abstract: Provided are a method for creating a cell mathematical model capable of evaluating characteristics of cells from experimental data, a program, and a creation apparatus. Also provided are a method for determining the created cell mathematical model, a program, and a determination apparatus. The method for creating a mathematical model receives culture data of the cells, extracts feature values of cell activity from the culture data, creates a cell mathematical model from the feature values, and outputs the cell mathematical model. The method for determining the created cell mathematical model determines that estimated culture data calculated using the cell mathematical model reflects the culture data.
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12.发明公开公开(公告)号：US20240170098A1
公开(公告)日：2024-05-23
申请号：US18397304
申请日：2023-12-27
Applicant: FUJIFILM Corporation
Inventor： Takahiro TERAO , Masaya NAGASE
Abstract: Provided are a method for predicting a cell culture result, a culture result prediction program, and a culture result prediction apparatus that predict a culture result of an entire culture process. The method for predicting a cell culture result includes receiving a culture environment including a culture medium composition and a culture condition for culturing cells; predicting a biological behavior amount on the basis of the culture environment; changing a cell environment on the basis of the predicted biological behavior amount; repeating prediction of the biological behavior amount and change of the cell environment on the basis of the changed cell environment; and outputting the changed cell environment. Further, a culture result prediction program for executing the method for predicting a cell culture result, and a culture result prediction apparatus are provided.
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13.发明申请公开(公告)号：US20190340513A1
公开(公告)日：2019-11-07
申请号：US16513202
申请日：2019-07-16
Applicant: FUJIFILM Corporation
Inventor： Masaya NAGASE
Abstract: Provided is an optimal solution determination method for determining optimality of a solution in a combinatorial optimization problem using a computer, including uniformly extracting a plurality of solutions in a solution space of the combinatorial optimization problem as a plurality of first solutions, and estimating a maximum evaluation value in a case where solutions of a number that exceeds the number of the plurality of first solutions are assumed, on the basis of a plurality of first evaluation values respectively corresponding to the plurality of first solutions that are uniformly extracted, as a first maximum evaluation value Z. Further, in a case where a solution candidate (graph G_1) that belongs to a solution space is input (step S18), an evaluation value S_1 corresponding to the graph G_1 is acquired, the acquired evaluation value S_1 is compared with the first maximum evaluation value Z, and it is determined whether the evaluation value S_1 of the input graph G_1 is within a confidence interval of the first maximum evaluation value Z (whether the graph G_1 is a first optimal value or not).
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14.发明申请公开(公告)号：US20190065963A1
公开(公告)日：2019-02-28
申请号：US16054684
申请日：2018-08-03
Applicant: FUJIFILM Corporation
Inventor： Masaya NAGASE
Abstract: An optimal solution search method for searching for an optimal solution in a combinatorial optimization problem using a computer, includes: acquiring a first solution candidate; and enumerating and indexing solution candidate groups of which the degree of divergence from the first solution candidate is equal to or smaller than a predetermined range; equally extracting second solution candidates from the enumerated and indexed solution candidate groups assigning evaluation values to the second solution candidates; and determining whether the search for the optimal solution is terminated on the basis of the evaluation value. In a case where the search for the optimal solution is not terminated, the current first solution candidate is updated as the best second solution candidate selected from the second solution candidates, and the processes are repeated until the search for the first optimal solution is terminated.
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Patent Agency Ranking
公开(公告)号：US20250022545A1
公开(公告)日：2025-01-16
申请号：US18899296
申请日：2024-09-27
Applicant: Fujifilm Corporation
Inventor： Masaya NAGASE , Sho Takemori
IPC: G16C20/30
Abstract: A method includes: a prediction step of predicting, for a target cell, a culture result for a culture medium composition by using a cell characteristic or an estimated value of a cell characteristic of the target cell; an acquisition step of acquiring a culture result of the target cell for the culture medium composition; an estimation step of estimating a cell characteristic of the target cell by using the culture medium composition and the culture result or the predicted culture result; an evaluation step of evaluating necessity to further estimate a cell characteristic of the target cell from the culture result; a search determination step of searching and determining a candidate culture medium composition, based on the necessity and the prediction, the candidate culture medium composition to be acquired next in the acquisition step; and a control step of repeating the above-described steps until a termination criterion is satisfied.
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公开(公告)号：US20250019638A1
公开(公告)日：2025-01-16
申请号：US18899288
申请日：2024-09-27
Applicant: FUJIFILM Corporation
Inventor： Masaya NAGASE , Sho TAKEMORI
Abstract: A configuration method according to an aspect of the present invention is a configuration method for configuring a culture medium panel constituted by a plurality of culture media to optimize a cell culture result. The configuration method includes, by a processor, a region setting step of setting a region of a culture medium composition space; a characteristic listing step of listing a plurality of cell characteristics; a prediction step of making a prediction of a culture result of a target cell for a given culture medium composition, based on a cell characteristic of the target cell; a search listing step of searching for and listing, for respective cell characteristics included in the plurality of cell characteristics, culture medium compositions for which cell culture results have local maximum values; and a configuration step of configuring the culture medium panel from culture medium composition candidates corresponding to the local maximum values.
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公开(公告)号：US20230066188A1
公开(公告)日：2023-03-02
申请号：US18053373
申请日：2022-11-08
Applicant: FUJIFILM CORPORATION
Inventor： Yuta MURAKAMI , Masaya NAGASE , Yukihisa NOGUCHI
Abstract: Provided are a biomarker identifying method including (1) to (4) and an application thereof. (1) An evaluation value for each of a plurality of biomarkers is derived based on annotation information imparted to each of biomarkers, and a measurement target biomarker is selected based on the evaluation value. (2) The evaluation data of the measurement target biomarker is acquired from the cell A and/or the culture system, before the start of culture of the cell A and/or during the culture. (3) The evaluation data of the discrimination marker of the B cell is acquired from the cell A and/or the culture system, at the final stage of the culture of the cell A and/or after the end of the culture. (4) At least one biomarker indicating characteristics of the cell A is identified from among the measurement target biomarkers, based on the data obtained from (2) and (3).
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公开(公告)号：US20220017872A1
公开(公告)日：2022-01-20
申请号：US17487833
申请日：2021-09-28
Applicant: FUJIFILM Corporation
Inventor： Yuta MURAKAMI , Masaya NAGASE
Abstract: An object of the present invention is to provide a producing method for a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a producing method for a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a producing method for a differentiated cell, and a differentiated cell. According to the present invention, there is provided a method for quality evaluation of a pluripotent stem cell. Further, according to the present invention, there is provided a method of screening a pluripotent stem cell capable of differentiating into a specific cell.
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公开(公告)号：US20210087517A1
公开(公告)日：2021-03-25
申请号：US17114501
申请日：2020-12-08
Applicant: FUJIFILM CORPORATION
Inventor： Yuta MURAKAMI , Tatsuya FUJINAMI , Kenta MATSUBARA , Katsuko SATO , Ayako YAMAMOTO , Hidetoshi TAKAYAMA , Takashi WAKUI , Satoshi AIBA , Shinichi KIKUCHI , Masaya NAGASE , Xiao LING
Abstract: Provided is an information processing apparatus including an acquiring unit that acquires cell information indicating a state of a cell from production of a pluripotent stem cell to differentiation of the pluripotent stem cell into a specific differentiated cell by differentiation induction, and process history information indicating a history of a processing process for obtaining the differentiated cell, and a deriving unit that derives differentiation potency information indicating differentiation potency of the pluripotent stem cell based on the cell information and the process history information which are acquired by the acquiring unit.
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